Cancer Stem Cell News Volume 10.12 | Mar 31 2021

31-03-2021 | CSCN 10.12

Cancer Stem Cell News by STEMCELL Technologies
Vol. 10.12 – 31 March, 2021

Rapid Reprogramming of Tumor Cells into Cancer Stem Cells on Double-Network Hydrogels

Researchers showed that a double-network hydrogel could rapidly reprogram differentiated cancer cells into cancer stem cells.
[Nature Biomedical Engineering]

Survey results on the insights and hurdles of CRISPR genome editing.
PUBLICATIONSRanked by the impact factor of the journal

Faciogenital Dysplasia 5 Supports Cancer Stem Cell Traits in Basal-Like Breast Cancer by Enhancing EGFR Stability

Scientists performed the basal-like breast cancers (BLBC) tissue microarray-based immunohistochemical analysis and showed that Faciogenital Dysplasia 5 (FGD5) abundance was associated with poor prognosis in BLBCs. FGD5 deletion decreased the proliferation, invasion, and tumorsphere formation capacity of BLBC cells.
[Science Translational Medicine]


HOXBLINC Long Non-Coding RNA Activation Promotes Leukemogenesis in NPM1-Mutant Acute Myeloid Leukemia

Investigators showed that the activation of HOXBLINC, a HOXB locus-associated long non-coding RNA, was a critical downstream mediator of NPM1c+-associated leukemic transcription program and leukemogenesis.
[Nature Communications]

Full Article

FOSL1 Promotes Metastasis of Head and Neck Squamous Cell Carcinoma through Super-Enhancer-Driven Transcription Program

The authors demonstrated that FOSL1 served as the dominate AP1 family member and was significantly upregulated in head and neck squamous cell carcinoma (HNSCC) tumor tissues and correlated with metastasis of HNSCC.
[Molecular Therapy]

AbstractGraphical Abstract

Polyploid Giant Cancer Cells, Stemness and Epithelial-Mesenchymal Plasticity Elicited by Human Cytomegalovirus

Human cytomegalovirus presence paralleled the succession of the observed cellular and molecular events potentially ensuing the transformation process.


CircFAM73A Promotes the Cancer Stem Cell-Like Properties of Gastric Cancer through the miR-490-3p/HMGA2 Positive Feedback Loop and HNRNPK-Mediated β-Catenin Stabilization

The roles of circFAM73A in gastric cancer cell proliferation, migration, cisplatin resistance, and CSC-like properties were determined by a series of functional experiments both in vitro and in vivo.
[Journal of Experimental & Clinical Cancer Research]

Full Article

Co-Dependency for MET and FGFR1 in Basal Triple-Negative Breast Cancers

Investigators utilized an established Met-dependent transgenic mouse model of TNBC, human cell lines and patient-derived xenografts to investigate the role of MET in TNBC tumorigenesis.
[npj Breast Cancer]

Full Article

Long Noncoding RNA McF2l-AS1 Promotes the Cancer Stem Cell-Like Traits in Non-Small Cell Lung Cancer Cells through Regulating miR-873-5p Level

Functional experiments showed that MCF2L‐AS1 knockdown suppressed the CSC‐like traits of non-small cell lung cancer cells through qRT‐PCR, western blot, tumor‐sphere formation, and ALDH activity detection.
[Environmental Toxicology]


Anticancer Effects of Non-Steroidal Anti-Inflammatory Drugs against Cancer Cells and Cancer Stem Cells

Investigators identified non-steroidal anti-inflammatory drugs (NSAIDs) that enhanced the anticancer effect of cisplatin; the effects of 17 NSAIDs in lung cancer cells and their spheroids as CSCs were evaluated.
[Toxicology in Vitro]

AbstractGraphical Abstract

Zinc‐Finger E‐Box‐Binding Homeobox 1 (ZEB1) Plays a Crucial Role in the Maintenance of Lung Cancer Stem Cells Resistant to Gefitinib

PC9 and HCC827 non‐small cell lung cancer cell lines were treated with high concentrations of gefitinib, and surviving cells were referred to as “gefitinib‐resistant persisters” (GRPs). Zinc‐finger E‐box‐binding homeobox 1 (ZEB1) knockdown or overexpression was performed to determine the biological significance of ZEB1 in the cancer stem cell features of GRPs, and animal models were studied for in vivo validation.
[Thoracic Cancer]

Full Article
New human primary cancer-sourced blood products, immune cell subsets, and more. Click to view products.

Role of Glioblastoma Stem Cells in Cancer Therapeutic Resistance: A Perspective on Antineoplastic Agents from Natural Sources and Chemical Derivatives

Scientists describe major intrinsic and extrinsic mechanisms that mediate chemoradioresistant glioblastoma stem cells and therapies based on antineoplastic agents from natural sources, derivatives, and synthetics used alone or in synergistic combination with conventional treatment.
[Current Stem Cell Research & Therapy]

Full Article

Rafael Pharmaceuticals Crosses Enrollment of 150 Patients in Pivotal Phase III Trial (ARMADA 2000) of CPI-613® (Devimistat) for Relapsed or Refractory Acute Myeloid Leukemia (AML)

Rafael Pharmaceuticals, Inc. announced that it has crossed the enrollment of 150 patients in its Phase III clinical trial for patients with relapsed or refractory AML.
[Rafael Pharmaceuticals, Inc. (GlobeNewswire, Inc.)]

Press Release

Myovant Sciences Announces Recipients of “Forward for Health Equity” Grants to Improve Healthcare Access in Prostate Cancer and Uterine Fibroids

Myovant Sciences announced the four recipients of its Forward for Health Equity grants. The grant program provides funding to nonprofit healthcare organizations with innovative projects focused on improving healthcare access, with an initial focus on reducing racial disparities in prostate cancer and uterine fibroids in the US.
[Myovant Sciences]

Press Release

The American Association for Cancer Research (AACR) Annual Meeting 2021: Week 2

May 17 – 21, 2021

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Journal Editor – Blood Cancer Discovery and Cancer Immunology

American Association for Cancer Research – Boston, Massachusetts, United States

Postdoctoral Fellow – Myeloma Tumor Microenvironment

Moores Cancer Center – La Jolla, California, United States

Medicinal Chemist – Muscle-Wasting, Neurodegeneration, and Oncology

Almac – Belfast, Ireland

Director – Ginny L. Clements Breast Cancer Research Institute

University of Arizona Cancer Center – Tucson, Arizona, United States

Research Coordinator – Breast Oncology

Baylor College of Medicine – Houston, Texas, United States

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