 | | Vol. 10.12 – 31 March, 2021 |
| |
|
|
| Researchers showed that a double-network hydrogel could rapidly reprogram differentiated cancer cells into cancer stem cells.
[Nature Biomedical Engineering] |
|  |
|
|
| PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Scientists performed the basal-like breast cancers (BLBC) tissue microarray-based immunohistochemical analysis and showed that Faciogenital Dysplasia 5 (FGD5) abundance was associated with poor prognosis in BLBCs. FGD5 deletion decreased the proliferation, invasion, and tumorsphere formation capacity of BLBC cells.
[Science Translational Medicine] |
|
|
|
| Investigators showed that the activation of HOXBLINC, a HOXB locus-associated long non-coding RNA, was a critical downstream mediator of NPM1c+-associated leukemic transcription program and leukemogenesis.
[Nature Communications] |
|
|
|
| The authors demonstrated that FOSL1 served as the dominate AP1 family member and was significantly upregulated in head and neck squamous cell carcinoma (HNSCC) tumor tissues and correlated with metastasis of HNSCC.
[Molecular Therapy] |
|
|
|
| Human cytomegalovirus presence paralleled the succession of the observed cellular and molecular events potentially ensuing the transformation process.
[Oncogene] |
|
|
|
| The roles of circFAM73A in gastric cancer cell proliferation, migration, cisplatin resistance, and CSC-like properties were determined by a series of functional experiments both in vitro and in vivo.
[Journal of Experimental & Clinical Cancer Research] |
|
|
|
| Investigators utilized an established Met-dependent transgenic mouse model of TNBC, human cell lines and patient-derived xenografts to investigate the role of MET in TNBC tumorigenesis.
[npj Breast Cancer] |
|
|
|
| Functional experiments showed that MCF2L‐AS1 knockdown suppressed the CSC‐like traits of non-small cell lung cancer cells through qRT‐PCR, western blot, tumor‐sphere formation, and ALDH activity detection.
[Environmental Toxicology] |
|
|
|
| Investigators identified non-steroidal anti-inflammatory drugs (NSAIDs) that enhanced the anticancer effect of cisplatin; the effects of 17 NSAIDs in lung cancer cells and their spheroids as CSCs were evaluated.
[Toxicology in Vitro] |
|
|
|
| PC9 and HCC827 non‐small cell lung cancer cell lines were treated with high concentrations of gefitinib, and surviving cells were referred to as “gefitinib‐resistant persisters” (GRPs). Zinc‐finger E‐box‐binding homeobox 1 (ZEB1) knockdown or overexpression was performed to determine the biological significance of ZEB1 in the cancer stem cell features of GRPs, and animal models were studied for in vivo validation.
[Thoracic Cancer] |
|
|
|
|
| Scientists describe major intrinsic and extrinsic mechanisms that mediate chemoradioresistant glioblastoma stem cells and therapies based on antineoplastic agents from natural sources, derivatives, and synthetics used alone or in synergistic combination with conventional treatment.
[Current Stem Cell Research & Therapy] |
|
|
|
|
| Rafael Pharmaceuticals, Inc. announced that it has crossed the enrollment of 150 patients in its Phase III clinical trial for patients with relapsed or refractory AML.
[Rafael Pharmaceuticals, Inc. (GlobeNewswire, Inc.)] |
|
|
|
| Myovant Sciences announced the four recipients of its Forward for Health Equity grants. The grant program provides funding to nonprofit healthcare organizations with innovative projects focused on improving healthcare access, with an initial focus on reducing racial disparities in prostate cancer and uterine fibroids in the US.
[Myovant Sciences] |
|
|
|
|
|
|
|
| | American Association for Cancer Research – Boston, Massachusetts, United States |
|
|
|
| | Moores Cancer Center – La Jolla, California, United States |
|
|
|
|
| | University of Arizona Cancer Center – Tucson, Arizona, United States |
|
|
|
| | Baylor College of Medicine – Houston, Texas, United States |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
