Cancer Stem Cell News Volume 10.12 | Mar 31 2021

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    31-03-2021 | CSCN 10.12


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 10.12 – 31 March, 2021
    TOP STORY

    Rapid Reprogramming of Tumor Cells into Cancer Stem Cells on Double-Network Hydrogels

    Researchers showed that a double-network hydrogel could rapidly reprogram differentiated cancer cells into cancer stem cells.
    [Nature Biomedical Engineering]

    Abstract
    Survey results on the insights and hurdles of CRISPR genome editing.
    PUBLICATIONSRanked by the impact factor of the journal

    Faciogenital Dysplasia 5 Supports Cancer Stem Cell Traits in Basal-Like Breast Cancer by Enhancing EGFR Stability

    Scientists performed the basal-like breast cancers (BLBC) tissue microarray-based immunohistochemical analysis and showed that Faciogenital Dysplasia 5 (FGD5) abundance was associated with poor prognosis in BLBCs. FGD5 deletion decreased the proliferation, invasion, and tumorsphere formation capacity of BLBC cells.
    [Science Translational Medicine]

    Abstract

    HOXBLINC Long Non-Coding RNA Activation Promotes Leukemogenesis in NPM1-Mutant Acute Myeloid Leukemia

    Investigators showed that the activation of HOXBLINC, a HOXB locus-associated long non-coding RNA, was a critical downstream mediator of NPM1c+-associated leukemic transcription program and leukemogenesis.
    [Nature Communications]

    Full Article

    FOSL1 Promotes Metastasis of Head and Neck Squamous Cell Carcinoma through Super-Enhancer-Driven Transcription Program

    The authors demonstrated that FOSL1 served as the dominate AP1 family member and was significantly upregulated in head and neck squamous cell carcinoma (HNSCC) tumor tissues and correlated with metastasis of HNSCC.
    [Molecular Therapy]

    AbstractGraphical Abstract

    Polyploid Giant Cancer Cells, Stemness and Epithelial-Mesenchymal Plasticity Elicited by Human Cytomegalovirus

    Human cytomegalovirus presence paralleled the succession of the observed cellular and molecular events potentially ensuing the transformation process.
    [Oncogene]

    Abstract

    CircFAM73A Promotes the Cancer Stem Cell-Like Properties of Gastric Cancer through the miR-490-3p/HMGA2 Positive Feedback Loop and HNRNPK-Mediated β-Catenin Stabilization

    The roles of circFAM73A in gastric cancer cell proliferation, migration, cisplatin resistance, and CSC-like properties were determined by a series of functional experiments both in vitro and in vivo.
    [Journal of Experimental & Clinical Cancer Research]

    Full Article

    Co-Dependency for MET and FGFR1 in Basal Triple-Negative Breast Cancers

    Investigators utilized an established Met-dependent transgenic mouse model of TNBC, human cell lines and patient-derived xenografts to investigate the role of MET in TNBC tumorigenesis.
    [npj Breast Cancer]

    Full Article

    Long Noncoding RNA McF2l-AS1 Promotes the Cancer Stem Cell-Like Traits in Non-Small Cell Lung Cancer Cells through Regulating miR-873-5p Level

    Functional experiments showed that MCF2L‐AS1 knockdown suppressed the CSC‐like traits of non-small cell lung cancer cells through qRT‐PCR, western blot, tumor‐sphere formation, and ALDH activity detection.
    [Environmental Toxicology]

    Abstract

    Anticancer Effects of Non-Steroidal Anti-Inflammatory Drugs against Cancer Cells and Cancer Stem Cells

    Investigators identified non-steroidal anti-inflammatory drugs (NSAIDs) that enhanced the anticancer effect of cisplatin; the effects of 17 NSAIDs in lung cancer cells and their spheroids as CSCs were evaluated.
    [Toxicology in Vitro]

    AbstractGraphical Abstract

    Zinc‐Finger E‐Box‐Binding Homeobox 1 (ZEB1) Plays a Crucial Role in the Maintenance of Lung Cancer Stem Cells Resistant to Gefitinib

    PC9 and HCC827 non‐small cell lung cancer cell lines were treated with high concentrations of gefitinib, and surviving cells were referred to as “gefitinib‐resistant persisters” (GRPs). Zinc‐finger E‐box‐binding homeobox 1 (ZEB1) knockdown or overexpression was performed to determine the biological significance of ZEB1 in the cancer stem cell features of GRPs, and animal models were studied for in vivo validation.
    [Thoracic Cancer]

    Full Article
    New human primary cancer-sourced blood products, immune cell subsets, and more. Click to view products.
    REVIEWS

    Role of Glioblastoma Stem Cells in Cancer Therapeutic Resistance: A Perspective on Antineoplastic Agents from Natural Sources and Chemical Derivatives

    Scientists describe major intrinsic and extrinsic mechanisms that mediate chemoradioresistant glioblastoma stem cells and therapies based on antineoplastic agents from natural sources, derivatives, and synthetics used alone or in synergistic combination with conventional treatment.
    [Current Stem Cell Research & Therapy]

    Full Article
    INDUSTRY AND POLICY NEWS

    Rafael Pharmaceuticals Crosses Enrollment of 150 Patients in Pivotal Phase III Trial (ARMADA 2000) of CPI-613® (Devimistat) for Relapsed or Refractory Acute Myeloid Leukemia (AML)

    Rafael Pharmaceuticals, Inc. announced that it has crossed the enrollment of 150 patients in its Phase III clinical trial for patients with relapsed or refractory AML.
    [Rafael Pharmaceuticals, Inc. (GlobeNewswire, Inc.)]

    Press Release

    Myovant Sciences Announces Recipients of “Forward for Health Equity” Grants to Improve Healthcare Access in Prostate Cancer and Uterine Fibroids

    Myovant Sciences announced the four recipients of its Forward for Health Equity grants. The grant program provides funding to nonprofit healthcare organizations with innovative projects focused on improving healthcare access, with an initial focus on reducing racial disparities in prostate cancer and uterine fibroids in the US.
    [Myovant Sciences]

    Press Release
    FEATURED EVENT

    The American Association for Cancer Research (AACR) Annual Meeting 2021: Week 2

    May 17 – 21, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Journal Editor – Blood Cancer Discovery and Cancer Immunology

    American Association for Cancer Research – Boston, Massachusetts, United States

    Postdoctoral Fellow – Myeloma Tumor Microenvironment

    Moores Cancer Center – La Jolla, California, United States

    Medicinal Chemist – Muscle-Wasting, Neurodegeneration, and Oncology

    Almac – Belfast, Ireland

    Director – Ginny L. Clements Breast Cancer Research Institute

    University of Arizona Cancer Center – Tucson, Arizona, United States

    Research Coordinator – Breast Oncology

    Baylor College of Medicine – Houston, Texas, United States

    > See All Jobs

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