 | | Vol. 10.13 – 07 April, 2021 |
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| Scientists demonstrated that Bcl3 impacted pancreatic carcinogenesis by restraining CSC expansion and by curtailing an aggressive and metastatic tumor burden in pancreatic ductal adenocarcinoma across species.
[Gastroenterology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers showed that miR-146 was relevant for normal mammary stem cell and mammary cancer stem cell activity.
[Journal of Cell Biology] |
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| Scientists found that leukemic stem cells in chronic myelomonocytic leukemia resided in a CD34+/CD38− fraction of the malignant clone.
[Leukemia] |
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| The authors report that C3G downregulation promoted the acquisition of a more mesenchymal phenotype that enhanced the migratory and invasive capacity of glioblastoma cells.
[Cell Death & Disease] |
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| Loss of PTEN in fallopian tube epithelium led to the enrichment of CSC markers such as LGR5, WNT4, ALDH1, CD44.
[Cell Death & Disease] |
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| Investigators identified that both ectopic wild type and nonISGylatable mutant interferon‐stimulated gene 15 (ISG15) expression inhibited CSC‐like phenotypes of cisplatin‐resistant ovarian cancer cells.
[Journal of Cellular and Molecular Medicine] |
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| Researchers investigated the inhibitory effect of nitidine chloride on the epithelial‐mesenchymal transition process and stem cell‐like properties in glioma cells.
[Cancer Medicine] |
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| The authors found that tideglusib (TID) markedly reduced the cell viability of different osteosarcoma cell lines. Cell cycle arrest distributed in G2/M was markedly up-regulated in TID-incubated osteosarcoma cells through enhancing p21 expression levels.
[Biochemical and Biophysical Research Communications] |
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| Scientists identified a clinically relevant signaling nexus mediated by AXL receptor, PYK2 and PKCα and show its impact on stemness in triple-negative breast cancer.
[Life Science Alliance] |
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| Investigators used breast cancer as an example of the origins of tumor heterogeneity and of tumor cell plasticity, as well as considering interclonal cooperativity and cell plasticity as sources of cancer cell heterogeneity.
[British Journal of Cancer] |
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| The authors made an attempt to scrutinize evidence that indicates the role of stem cells in tumorigenesis and metastasis, and cancer relapse.
[Experimental Biology and Medicine] |
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| Bio-Path Holdings, Inc. announced the successful completion of the safety run-in of the Stage II of the Phase II clinical study of prexigebersen, a liposomal Grb2 antisense, for the treatment of acute myeloid leukemia (AML), in combination with frontline therapies, decitabine and venetoclax, in AML patients.
[Bio-Path Holdings, Inc.] |
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| Turning Point Therapeutics, Inc. a precision oncology company developing next-generation therapies that target genetic drivers of cancer, today reported initial clinical data from the ongoing Phase I/II SWORD-1 study of its RET inhibitor drug candidate, TPX-0046.
[Turning Point Therapeutics, Inc. (Globe Newswire, Inc.)] |
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| Kite announced that it has submitted a supplemental Biologics License Application to FDA for Tecartus® for the treatment of adult patients with relapsed or refractory B-cell precursor acute lymphoblastic leukemia (ALL).
[Kite (BusinessWire, Inc.)] |
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| | Rutgers University – New Brunswick, New Jersey, United States |
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| | The University of Texas Southwestern Medical Center – Dallas, Texas, United States |
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| | American Association for Cancer Research – Boston, Massachusetts, United States |
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| | Moores Cancer Center – La Jolla, California, United States |
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