 | | Vol. 10.13 – 14 April, 2021 |
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| Researchers demonstrated that a key GAS6/AXL axis was highly activated in acute myeloid leukemia patient cells, particularly in stem/progenitor cells.
[Blood] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Both immunohistochemistry and Western blot assays demonstrated that the expression of PR domain zinc finger protein 4 (PRDM4) in cervical cancer tissues was much lower than that in the normal cervix.
[Oncogene] |
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| Lupeol inhibited proliferation and induce apoptosis of retinoblastoma cells, with increased Bax level and decreased Ki67, survivin and Bcl-2 levels.
[Journal of Pharmacy and Pharmacology] |
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| Scientists report a Wnt ligand, Dickkopf-2 (DKK2) was essential for developing colorectal cancer stemness. Genetic depletion of Dkk2 in intestinal epithelial or stem cells reduced tumorigenesis as well as expression of the stem cell marker genes including Lgr5 in a model of colitis-associated cancer.
[iScience] |
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| Scientists report that TWIST1, an epithelial-to-mesenchymal transition (EMT) regulated by transcription factors, exhibited positive transcriptional regulation on PDGFRβ promoter, thus identifying PDGFRβ as one of the downstream targets of EMT regulation in breast CSCs.
[Biochimica Et Biophysica Acta-Molecular Basis of Disease] |
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| CSCs had low EGFR expression and, conversely, overexpressed the anti-apoptotic Bcl-2 protein, which is involved in resistance to apoptosis and the invasion/migration capacities of tumor cells.
[Journal of Cancer Research and Clinical Oncology] |
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| The expression of miR-98 in CD44+ gastric cancer stem cells (GCSCs) was verified by RT-PCR. The miR-98 was overexpressed in CD44+ GCSCs by Lentivirus.
[Life Sciences] |
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| Glioma stem cells (GSCs) were obtained from glioma cells and referred to as GSC‐87 and GSC‐251, respectively. The interactions between miR‐326 and SNHG9 or SOX9 were analyzed using luciferase reporter assay.
[Journal of Gene Medicine] |
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| Pancreatic ductal adenocarcinoma patients who underwent surgical resection between 01/2012–06/2014 were identified. CD44 and epithelial-specific antigen expression was assessed by immunohistochemistry.
[BMC Cancer] |
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| The clinical importance of myelodysplastic syndromes (MDS) stem cells has been highlighted through the demonstration of selective persistence of MDS stem cells in patients at complete remission in response to therapy.
[Journal of Internal Medicine] |
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| The authors highlight the processes involved in CSCs development and maintenance as well as the current effective therapies based on stem cells, cell-free therapies that involve exosomes and miRNAs, and photodynamic therapy.
[Life Sciences] |
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| Treovir, LLC has announced that G207, an oncolytic HSV immunotherapy, was well tolerated with evidence of clinical effectiveness in a Phase I study of 12 pediatric patients with recurrent high-grade glioma.
[Treovir, LLC (PR Newswire, LLC)] |
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| Arcellx announced that the FDA has cleared the company’s Investigational New Drug (IND) application for ACLX-001, an engineered cell therapy for the treatment of multiple myeloma. ACLX-001 is the first clinical application of the company’s ARC-SparX platform of controllable and adaptable cell therapies.
[Arcellx] |
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| June 14 – 18, 2021
Virtual |
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| | Columbia University Medical Center – New York, New York, United States |
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| | Karolinska Institutet – Huddinge, Sweden |
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| | The University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
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| | American Association for Cancer Research – Boston, Massachusetts, United States |
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| | Moores Cancer Center – La Jolla, California, United States |
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