Cancer Stem Cell News Volume 10.17 | May 5 2021

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    2021-05-05 | CSCN 10.17


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 10.17 – 5 May, 2021
    TOP STORY

    CD276 Expression Enables Squamous Cell Carcinoma Stem Cells to Evade Immune Surveillance

    The authors showed that CSCs upregulated the immune checkpoint molecule CD276 to evade host immune responses.
    [Cell Stem Cell]

    Abstract

    Find antibodies targeting cell markers relevant in neural research
    PUBLICATIONSRanked by the impact factor of the journal

    Cancer of Unknown Primary Stem-Like Cells Model Multi-Organ Metastasis and Unveil Liability to MEK Inhibition

    Scientists proposed that cancers of unknown primary are a distinct, yet unrecognized, pathological entity originating from stem-like cells endowed with peculiar and shared properties.
    [Nature Communications]

    Full Article

    Targeting Protein Lysine Methyltransferase G9A Impairs Self-Renewal of Chronic Myelogenous Leukemia Stem Cells via Upregulation of SOX6

    Investigators found that protein lysine methyltransferase G9A was overexpressed in chronic myelogenous leukemia leukemia stem cells.
    [Oncogene]

    Abstract

    Generating Human Prostate Cancer Organoids from Leukapheresis Enriched Circulating Tumor Cells

    Researchers used diagnostic leukapheresis to enrich circulating tumor cells from patients with metastatic prostate cancer and explored whether organoids provide a platform for ex vivo treatment modeling.
    [European Journal of Cancer]

    Full Article

    ALG3 Contributes to Stemness and Radioresistance through Regulating Glycosylation of TGF-β Receptor II in Breast Cancer

    The authors screened all ten asparagine-linked glycosylation (ALG) members in breast cancer patients’ samples by RT-PCR. Cancer stem-like traits were assessed by RT-PCR, Western blot, and flow cytometry.
    [Journal of Experimental & Clinical Cancer Research]

    Full Article

    A Novel Lnc408 Maintains Breast Cancer Stem Cell Stemness by Recruiting SP3 to Suppress CBY1 Transcription and Increasing Nuclear β-Catenin Levels

    Scientists identified a novel lncRNA 408 (lnc408) in epithelial-mesenchymal transition-related breast CSCs (BCSCs). The lnc408 was highly expressed in BCSCs in vitro and in vivo.
    [Cell Death & Disease]

    Full Article

    Circulating Tumor Cells and Cell-Free DNA as a Prognostic Factor in Metastatic Colorectal Cancer: The OMITERC Prospective Study

    The authors explored the prognostic role of liquid biopsy encompassing cell-free DNA and circulating tumor cells in KRAS mutated metastatic colorectal cancer.
    [British Journal of Cancer]

    AbstractEditorial

    Fzd7/Wnt7b Signaling Contributes to Stemness and Chemoresistance in Pancreatic Cancer

    Fzd7/Wnt7b knockdown could reduce pancreatic ductal adenocarcinoma cell stemness and chemoresistance by reducing the percentage of CSCs.
    [Cancer Medicine]

    Full Article

    Identification of Inhibitory Immune Checkpoints and Relevant Regulatory Pathways in Breast Cancer Stem Cells

    Investigators suggested that CD200 and CD276 were candidate inhibitory immune checkpoints in breast CSCs, which were potentially regulated by Wnt, TGF‐β, and hedgehog signaling.
    [Cancer Medicine]

    Full Article

    Detection of Metabolic Change in Glioblastoma Cells after Radiotherapy Using Hyperpolarized 13C-MRI

    Dynamic nuclear polarization‐magnetic resonance imaging chemical shift imaging with hyperpolarized [1‐13C] pyruvate was conducted to evaluate the metabolic change in glycolytic profiles after radiation of two glioma stem‐like cell‐derived gliomas and an adherent human glioblastoma cell line in an orthotopic xenograft mouse model.
    [Nmr in Biomedicine]

    Full Article

    Stem Cell Conference Registration Award
    REVIEWS

    Leukemia: A Model Metastatic Disease

    Scientists discuss the key molecular processes that facilitate metastasis in a variety of leukemic subtypes, the clinical significance of leukemic invasion into specific tissues, and the current pipeline of treatments targeting leukemia metastasis.
    [Nature Reviews Cancer]

    Abstract

    Drug Resistance in Metastatic Breast Cancer: Tumor Targeted Nanomedicine to the Rescue

    The authors discuss various nanomedicines designed to selectively target breast cancer, triple negative breast cancer, and breast CSCs.
    [International Journal of Molecular Sciences]

    Full ArticleGraphical Abstract

    INDUSTRY AND POLICY NEWS

    Hoth Therapeutics Announces Development of HT-KIT to Treat Multiple Orphan Diseases, Including Rare Cancers

    Hoth Therapeutics, Inc. announced it intends to pursue the development of its HT-KIT mRNA Frame Shifting Therapeutic for multiple orphan diseases, which are rare diseases. HT-KIT targets a shared cell signaling pathway that may have therapeutic potential for multiple rare cancers.
    [Hoth Therapeutics, Inc.]

    Press Release

    China’s Tianhe Launch Brings Hope to Space Experiments and Cancer Research

    For the first time in history, scientists will be able to send human organoids for advanced cancer studies into space- and they are sending them there onboard China’s future space station.
    [CTGN]

    Press Release

    FEATURED EVENT

    Congress of the European Hematology Association

    June 9 – 17, 2021
    Virtual

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    JOB OPPORTUNITIES

    Senior Scientific Editor – Cell Stem Cell

    Elsevier – Cambridge, Massachusetts, United States

    Postdoctoral Fellow – Pediatric Oncology

    Dana-Farber Cancer Institute – Boston, Massachusetts, United States

    Senior Research Assistant – Leukemia

    University of Texas MD Anderson Cancer Center – Houston, Texas, United States

    Senior Postdoctoral Scientist – AML and Related Cancers

    Cyprus Cancer Research Institute – Nicosia, Cyprus

    Postdoctoral Fellow – Myeloma Tumor Microenvironment

    Moores Cancer Center – La Jolla, California, United States

    > See All Jobs

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