Cancer Stem Cell News Volume 10.17 | May 5 2021

2021-05-05 | CSCN 10.17

Cancer Stem Cell News by STEMCELL Technologies
Vol. 10.17 – 5 May, 2021

CD276 Expression Enables Squamous Cell Carcinoma Stem Cells to Evade Immune Surveillance

The authors showed that CSCs upregulated the immune checkpoint molecule CD276 to evade host immune responses.
[Cell Stem Cell]


Find antibodies targeting cell markers relevant in neural research
PUBLICATIONSRanked by the impact factor of the journal

Cancer of Unknown Primary Stem-Like Cells Model Multi-Organ Metastasis and Unveil Liability to MEK Inhibition

Scientists proposed that cancers of unknown primary are a distinct, yet unrecognized, pathological entity originating from stem-like cells endowed with peculiar and shared properties.
[Nature Communications]

Full Article

Targeting Protein Lysine Methyltransferase G9A Impairs Self-Renewal of Chronic Myelogenous Leukemia Stem Cells via Upregulation of SOX6

Investigators found that protein lysine methyltransferase G9A was overexpressed in chronic myelogenous leukemia leukemia stem cells.


Generating Human Prostate Cancer Organoids from Leukapheresis Enriched Circulating Tumor Cells

Researchers used diagnostic leukapheresis to enrich circulating tumor cells from patients with metastatic prostate cancer and explored whether organoids provide a platform for ex vivo treatment modeling.
[European Journal of Cancer]

Full Article

ALG3 Contributes to Stemness and Radioresistance through Regulating Glycosylation of TGF-β Receptor II in Breast Cancer

The authors screened all ten asparagine-linked glycosylation (ALG) members in breast cancer patients’ samples by RT-PCR. Cancer stem-like traits were assessed by RT-PCR, Western blot, and flow cytometry.
[Journal of Experimental & Clinical Cancer Research]

Full Article

A Novel Lnc408 Maintains Breast Cancer Stem Cell Stemness by Recruiting SP3 to Suppress CBY1 Transcription and Increasing Nuclear β-Catenin Levels

Scientists identified a novel lncRNA 408 (lnc408) in epithelial-mesenchymal transition-related breast CSCs (BCSCs). The lnc408 was highly expressed in BCSCs in vitro and in vivo.
[Cell Death & Disease]

Full Article

Circulating Tumor Cells and Cell-Free DNA as a Prognostic Factor in Metastatic Colorectal Cancer: The OMITERC Prospective Study

The authors explored the prognostic role of liquid biopsy encompassing cell-free DNA and circulating tumor cells in KRAS mutated metastatic colorectal cancer.
[British Journal of Cancer]


Fzd7/Wnt7b Signaling Contributes to Stemness and Chemoresistance in Pancreatic Cancer

Fzd7/Wnt7b knockdown could reduce pancreatic ductal adenocarcinoma cell stemness and chemoresistance by reducing the percentage of CSCs.
[Cancer Medicine]

Full Article

Identification of Inhibitory Immune Checkpoints and Relevant Regulatory Pathways in Breast Cancer Stem Cells

Investigators suggested that CD200 and CD276 were candidate inhibitory immune checkpoints in breast CSCs, which were potentially regulated by Wnt, TGF‐β, and hedgehog signaling.
[Cancer Medicine]

Full Article

Detection of Metabolic Change in Glioblastoma Cells after Radiotherapy Using Hyperpolarized 13C-MRI

Dynamic nuclear polarization‐magnetic resonance imaging chemical shift imaging with hyperpolarized [1‐13C] pyruvate was conducted to evaluate the metabolic change in glycolytic profiles after radiation of two glioma stem‐like cell‐derived gliomas and an adherent human glioblastoma cell line in an orthotopic xenograft mouse model.
[Nmr in Biomedicine]

Full Article

Stem Cell Conference Registration Award

Leukemia: A Model Metastatic Disease

Scientists discuss the key molecular processes that facilitate metastasis in a variety of leukemic subtypes, the clinical significance of leukemic invasion into specific tissues, and the current pipeline of treatments targeting leukemia metastasis.
[Nature Reviews Cancer]


Drug Resistance in Metastatic Breast Cancer: Tumor Targeted Nanomedicine to the Rescue

The authors discuss various nanomedicines designed to selectively target breast cancer, triple negative breast cancer, and breast CSCs.
[International Journal of Molecular Sciences]

Full ArticleGraphical Abstract


Hoth Therapeutics Announces Development of HT-KIT to Treat Multiple Orphan Diseases, Including Rare Cancers

Hoth Therapeutics, Inc. announced it intends to pursue the development of its HT-KIT mRNA Frame Shifting Therapeutic for multiple orphan diseases, which are rare diseases. HT-KIT targets a shared cell signaling pathway that may have therapeutic potential for multiple rare cancers.
[Hoth Therapeutics, Inc.]

Press Release

China’s Tianhe Launch Brings Hope to Space Experiments and Cancer Research

For the first time in history, scientists will be able to send human organoids for advanced cancer studies into space- and they are sending them there onboard China’s future space station.

Press Release


Congress of the European Hematology Association

June 9 – 17, 2021

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Senior Scientific Editor – Cell Stem Cell

Elsevier – Cambridge, Massachusetts, United States

Postdoctoral Fellow – Pediatric Oncology

Dana-Farber Cancer Institute – Boston, Massachusetts, United States

Senior Research Assistant – Leukemia

University of Texas MD Anderson Cancer Center – Houston, Texas, United States

Senior Postdoctoral Scientist – AML and Related Cancers

Cyprus Cancer Research Institute – Nicosia, Cyprus

Postdoctoral Fellow – Myeloma Tumor Microenvironment

Moores Cancer Center – La Jolla, California, United States

> See All Jobs

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