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| The authors showed that CSCs upregulated the immune checkpoint molecule CD276 to evade host immune responses. [Cell Stem Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists proposed that cancers of unknown primary are a distinct, yet unrecognized, pathological entity originating from stem-like cells endowed with peculiar and shared properties. [Nature Communications] |
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| Investigators found that protein lysine methyltransferase G9A was overexpressed in chronic myelogenous leukemia leukemia stem cells. [Oncogene] |
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| Researchers used diagnostic leukapheresis to enrich circulating tumor cells from patients with metastatic prostate cancer and explored whether organoids provide a platform for ex vivo treatment modeling. [European Journal of Cancer] |
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| The authors screened all ten asparagine-linked glycosylation (ALG) members in breast cancer patients’ samples by RT-PCR. Cancer stem-like traits were assessed by RT-PCR, Western blot, and flow cytometry. [Journal of Experimental & Clinical Cancer Research] |
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| Scientists identified a novel lncRNA 408 (lnc408) in epithelial-mesenchymal transition-related breast CSCs (BCSCs). The lnc408 was highly expressed in BCSCs in vitro and in vivo. [Cell Death & Disease] |
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| The authors explored the prognostic role of liquid biopsy encompassing cell-free DNA and circulating tumor cells in KRAS mutated metastatic colorectal cancer. [British Journal of Cancer] |
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| Fzd7/Wnt7b knockdown could reduce pancreatic ductal adenocarcinoma cell stemness and chemoresistance by reducing the percentage of CSCs. [Cancer Medicine] |
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| Investigators suggested that CD200 and CD276 were candidate inhibitory immune checkpoints in breast CSCs, which were potentially regulated by Wnt, TGF‐β, and hedgehog signaling. [Cancer Medicine] |
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| Dynamic nuclear polarization‐magnetic resonance imaging chemical shift imaging with hyperpolarized [1‐13C] pyruvate was conducted to evaluate the metabolic change in glycolytic profiles after radiation of two glioma stem‐like cell‐derived gliomas and an adherent human glioblastoma cell line in an orthotopic xenograft mouse model. [Nmr in Biomedicine] |
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| Scientists discuss the key molecular processes that facilitate metastasis in a variety of leukemic subtypes, the clinical significance of leukemic invasion into specific tissues, and the current pipeline of treatments targeting leukemia metastasis. [Nature Reviews Cancer] |
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| The authors discuss various nanomedicines designed to selectively target breast cancer, triple negative breast cancer, and breast CSCs. [International Journal of Molecular Sciences] |
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| Hoth Therapeutics, Inc. announced it intends to pursue the development of its HT-KIT mRNA Frame Shifting Therapeutic for multiple orphan diseases, which are rare diseases. HT-KIT targets a shared cell signaling pathway that may have therapeutic potential for multiple rare cancers. [Hoth Therapeutics, Inc.] |
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| For the first time in history, scientists will be able to send human organoids for advanced cancer studies into space- and they are sending them there onboard China’s future space station. [CTGN] |
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| June 9 – 17, 2021 Virtual |
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| Elsevier – Cambridge, Massachusetts, United States |
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| Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
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| University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
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| Cyprus Cancer Research Institute – Nicosia, Cyprus |
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| Moores Cancer Center – La Jolla, California, United States |
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