 | | Vol. 10.19 – 19 May, 2021 |
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| Investigators discovered and characterized a rare malignant peripheral nerve sheath tumor (MPNST) cell population with stem-cell-like properties, including quiescence, that was essential for tumor initiation and relapse.
[Cell Stem Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors uncovered a dual role for Rank in the mammary epithelia: Rank induced senescence and stemness, delaying tumor initiation but increasing tumor aggressiveness.
[Developmental Cell] |
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| Scientists found increased average methylation in mouse cutaneous squamous cell carcinomas (cSCC) as well as in stem-cell-like, but not keratinocyte-like, human cSCC.
[Ebiomedicine] |
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| The authors investigated the effect of direct contact of prostate cancer (PCa) cells with mesenchymal stem cells on the stemness of PCa and its mechanisms.
[Cell and Bioscience] |
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| Researchers indicated that a high level of glucose exposure does not affect the invasion and migration of PANC-1 cells, while aspartame increases both of these aggressiveness criteria.
[Food and Chemical Toxicology] |
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| The expression of Inhibitor of DNA binding and cell differentiation 4 (ID4), but not other ID family proteins, was enriched in LGR5-high colon cancer stem cells.
[Carcinogenesis] |
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| Investigators hypothesized that by creating an MHC independent vaccination, they would give rise to a sustained immune response against CD133 in triple-negative breast carcinomas.
[Molecular Therapy-Oncolytics] |
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| Using quantitative real-time PCR, the authors evaluated the expression of EPCAM, MUC1, CEA, HE4, and CA125 mRNAs, as putative markers of circulating tumor cells, in the blood of 51 epithelial ovarian cancer patients before and/or after adjuvant chemotherapy.
[Scientific Reports] |
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| Researchers reported that doublecortin‐like kinase 1 (DCLK1) influences small extracellular vesicle biogenesis in a kinase‐dependent manner.
[Proteomics] |
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| Scientists summarize the current knowledge on the biochemical characteristics of quiescent hematopoietic stem cells (HSCs) and leukemic stem cells (LSCs), the intracellular signaling pathways and the niche-driven mechanisms that control quiescence and the key differences between HSC- and LSC-quiescence.
[Blood Reviews] |
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| Investigators discuss the technologies for detection and enrichment of circulating tumor cells, as well as clinical applications involving circulating tumor cells.
[Molecular Therapy-Oncolytics] |
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| Context Therapeutics, Inc. and the Sidney Kimmel Cancer Center – Jefferson Health, announced the first patient has been dosed in the Phase II ONWARD 221 trial in patients with metastatic endometrial cancer.
[Context Therapeutics, Inc.] |
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| Coeptis Pharmaceuticals, Inc., has announced entry into two separate exclusive option agreements with VyGen-Bio, Inc., a majority-owned subsidiary of Vycellix, Inc., involving technologies being studied to potentially improve the treatment of CD38-related cancers.
[Coeptis Pharmaceuticals, Inc. (Cision US, Inc.)] |
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| June 21 – 26, 2021
Virtual |
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| | City of Hope – Duarte, California, United States |
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| | Cedars-Sinai – Los Angeles, California, United States |
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| | National Institutes of Health – Bethesda, Maryland, United States |
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| | Virginia Commonwealth University – Richmond, Virginia, United States |
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| | Case Western Reserve University – Cleveland, Ohio, United States |
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Cancer Stem Cell News
Cell Therapy News
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Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
