Cancer Stem Cell News Volume 10.23 | Jun 16 2021

2021-06-16 | CSCN 10.23

Cancer Stem Cell News by STEMCELL Technologies
Vol. 10.23 – 16 June, 2021

PELP1/Src-3-Dependent Regulation of Metabolic Pfkfb Kinases Drives Therapy Resistant ER+ Breast Cancer

Researchers showed that cytoplasmic complexes composed of steroid receptor co-activators, PELP1 and SRC-3, modulated breast CSC expansion through upregulation of the HIF-activated metabolic target genes PFKFB3 and PFKFB4.


Precision Oncology: Translating Discovery to the Clinic
PUBLICATIONSRanked by the impact factor of the journal

MCM8 Is Regulated by EGFR Signaling and Promotes the Growth of Glioma Stem Cells through Its Interaction with DNA-Replication-Initiating Factors

The role of mini-chromosome maintenance 8 (MCM8) in glioblastomas has remained unclear. Scientists investigated the biological functions and mechanisms of MCM8 in glioma stem cells.


Prrx1 Promotes Stemness and Angiogenesis via Activating TGF-β/Smad Pathway and Upregulating Proangiogenic Factors in Glioma

Aberrant expression of paired-related homeobox1 (Prrx1) has been functionally associated with cancer stem cells including glioma stem cells. Prrx1 was found to be markedly upregulated in glioma specimens and elevated Prrx1 expression was inversely correlated with the prognosis of glioma patients.
[Cell Death & Disease]

Full Article

Circulating Tumor Cell Number and Endocrine Therapy Index in ER Positive Metastatic Breast Cancer Patients

Circulating tumor cells enumeration at the initiation of endocrine therapy (ET), and at early and following time points was prognostic in ER-positive metastatic breast cancer starting second-line or later ET.
[npj Breast Cancer]

Full Article

Dissecting the Multi-Omics Atlas of the Exosomes Released by Human Lung Adenocarcinoma Stem-Like Cells

The authors presented a detailed transcriptome and proteome atlas of the exosomes released by human lung adenocarcinoma stem-like cells.
[npj Genomic Medicine]

Full Article

Single and Double Modified Salinomycin Analogs Target Stem-Like Cells in 2D and 3D Breast Cancer Models

A library of 17 C1-single and C1/C20-double modified salinomycin analogs was screened to identify compounds with improved activity against breast CSCs.
[Biomedicine & Pharmacotherapy]

Full ArticleGraphical Abstract

Macropinocytosis Requires Gal-3 in a Subset of Patient-Derived Glioblastoma Stem Cells

Using glioblastoma patient-derived stem cells, researchers identified and characterized a subset of Gal-3high glioblastoma tumors mainly within the mesenchymal subtype that are addicted to Gal-3-mediated macropinocytosis.
[Communications Biology]

Full Article

Carcinoma-Associated Fibroblasts Derived Exosomes Modulate Breast Cancer Cell Stemness through Exonic circHIF1A by miR-580-5p in Hypoxic Stress

Through investigating cellular functions including cell proliferation and stem cell features, it was demonstrated that hypoxic cancer-associated fibroblasts exosomes transferred circHIF1A into breast cancer cells, which played an important role in CSC properties sponging miR-580-5p by regulating CD44 expression.
[Cell Death Discovery]

Full Article

Biological Characteristics of a Sub-Population of Cancer Stem Cells from Two Triple-Negative Breast Tumor Cell Lines

The authors determined differences in ultrastructural morphology, proliferative capacity, and mouse-xenotransplantation characteristics of the MDA-MB-231 and MDA-MB-436 triple-negative breast tumor cell lines with the CD44high/CD24low phenotype in order to study their exosomes.

Full Article

Activate, expand, and differentiate your cells with cytokines, chemokines, and growth factors from STEMCELL Technologies.

Roles of Lysine-Specific Demethylase 1 (LSD1) in Homeostasis and Diseases

Investigators discuss the role of LSD1 in several aspects of cancer, such as hypoxia, epithelial-to-mesenchymal transition, stemness versus differentiation of CSCs, as well as anti-tumor immunity.
[Journal of Biomedical Science]

Full Article

The Impact of Fusion Genes on Cancer Stem Cells and Drug Resistance

As fusion genes are expressed explicitly in cancer cells, eradicating CSC by targeting fusion genes provides yet another advantage of negligible patient side effects since normal cells remain unaffected by the drug. Scientists delineate the latest evidence on how fusion genes regulate CSC and drug resistance.
[Molecular and Cellular Biochemistry]



(Venetoclax) Combination Shows Superior Progression-Free Survival Compared to Chlorambucil Plus Obinutuzumab in First-line Chronic Lymphocytic Leukemia (CLL) Phase III GLOW Study

AbbVie, Inc. announced new data from the Phase III GLOW study comparing the efficacy and safety of the combination of IMBRUVICA® plus VENCLEXTA®/VENCLYXTO® versus chlorambucil plus obinutuzumab for first-line treatment in patients with CLL or small lymphocytic lymphoma who had active disease requiring treatment per the International Workshop on CLL criteria.
[AbbVie, Inc.]

Press Release


EMBO Workshop: Lactate Unconventional Roles of a Nutrient Along Tumor Landscape

June 21 -23, 2021

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Life Science Research Professional

Stanford University – Stanford, California, United States

Research Associate – CNS Stem Cell Culture

Sana Biotechnology – Seattle, Washington, United States

Postdoctoral Fellow – Precision Oncology of Gastrointestinal Cancers

City of Hope – Monrovia, California, United States

Research Technologist – Neurological Surgery

Northwestern University – Chicago, Illinois, United States

Postdoctoral Positions – Hematopoiesis and Leukemia

UT Southwestern Medical Center – Dallas, Texas, United Statess

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