Cancer Stem Cell News Volume 10.23 | Jun 16 2021

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    Justin.choi
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    2021-06-16 | CSCN 10.23


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 10.23 – 16 June, 2021
    TOP STORY

    PELP1/Src-3-Dependent Regulation of Metabolic Pfkfb Kinases Drives Therapy Resistant ER+ Breast Cancer

    Researchers showed that cytoplasmic complexes composed of steroid receptor co-activators, PELP1 and SRC-3, modulated breast CSC expansion through upregulation of the HIF-activated metabolic target genes PFKFB3 and PFKFB4.
    [Oncogene]

    Abstract

    Precision Oncology: Translating Discovery to the Clinic
    PUBLICATIONSRanked by the impact factor of the journal

    MCM8 Is Regulated by EGFR Signaling and Promotes the Growth of Glioma Stem Cells through Its Interaction with DNA-Replication-Initiating Factors

    The role of mini-chromosome maintenance 8 (MCM8) in glioblastomas has remained unclear. Scientists investigated the biological functions and mechanisms of MCM8 in glioma stem cells.
    [Oncogene]

    Abstract

    Prrx1 Promotes Stemness and Angiogenesis via Activating TGF-β/Smad Pathway and Upregulating Proangiogenic Factors in Glioma

    Aberrant expression of paired-related homeobox1 (Prrx1) has been functionally associated with cancer stem cells including glioma stem cells. Prrx1 was found to be markedly upregulated in glioma specimens and elevated Prrx1 expression was inversely correlated with the prognosis of glioma patients.
    [Cell Death & Disease]

    Full Article

    Circulating Tumor Cell Number and Endocrine Therapy Index in ER Positive Metastatic Breast Cancer Patients

    Circulating tumor cells enumeration at the initiation of endocrine therapy (ET), and at early and following time points was prognostic in ER-positive metastatic breast cancer starting second-line or later ET.
    [npj Breast Cancer]

    Full Article

    Dissecting the Multi-Omics Atlas of the Exosomes Released by Human Lung Adenocarcinoma Stem-Like Cells

    The authors presented a detailed transcriptome and proteome atlas of the exosomes released by human lung adenocarcinoma stem-like cells.
    [npj Genomic Medicine]

    Full Article

    Single and Double Modified Salinomycin Analogs Target Stem-Like Cells in 2D and 3D Breast Cancer Models

    A library of 17 C1-single and C1/C20-double modified salinomycin analogs was screened to identify compounds with improved activity against breast CSCs.
    [Biomedicine & Pharmacotherapy]

    Full ArticleGraphical Abstract

    Macropinocytosis Requires Gal-3 in a Subset of Patient-Derived Glioblastoma Stem Cells

    Using glioblastoma patient-derived stem cells, researchers identified and characterized a subset of Gal-3high glioblastoma tumors mainly within the mesenchymal subtype that are addicted to Gal-3-mediated macropinocytosis.
    [Communications Biology]

    Full Article

    Carcinoma-Associated Fibroblasts Derived Exosomes Modulate Breast Cancer Cell Stemness through Exonic circHIF1A by miR-580-5p in Hypoxic Stress

    Through investigating cellular functions including cell proliferation and stem cell features, it was demonstrated that hypoxic cancer-associated fibroblasts exosomes transferred circHIF1A into breast cancer cells, which played an important role in CSC properties sponging miR-580-5p by regulating CD44 expression.
    [Cell Death Discovery]

    Full Article

    Biological Characteristics of a Sub-Population of Cancer Stem Cells from Two Triple-Negative Breast Tumor Cell Lines

    The authors determined differences in ultrastructural morphology, proliferative capacity, and mouse-xenotransplantation characteristics of the MDA-MB-231 and MDA-MB-436 triple-negative breast tumor cell lines with the CD44high/CD24low phenotype in order to study their exosomes.
    [Heliyon]

    Full Article

    Activate, expand, and differentiate your cells with cytokines, chemokines, and growth factors from STEMCELL Technologies.
    REVIEWS

    Roles of Lysine-Specific Demethylase 1 (LSD1) in Homeostasis and Diseases

    Investigators discuss the role of LSD1 in several aspects of cancer, such as hypoxia, epithelial-to-mesenchymal transition, stemness versus differentiation of CSCs, as well as anti-tumor immunity.
    [Journal of Biomedical Science]

    Full Article

    The Impact of Fusion Genes on Cancer Stem Cells and Drug Resistance

    As fusion genes are expressed explicitly in cancer cells, eradicating CSC by targeting fusion genes provides yet another advantage of negligible patient side effects since normal cells remain unaffected by the drug. Scientists delineate the latest evidence on how fusion genes regulate CSC and drug resistance.
    [Molecular and Cellular Biochemistry]

    Abstract

    INDUSTRY AND POLICY NEWS

    IMBRUVICA® (Ibrutinib) Plus VENCLEXTA®/VENCLYXTO®
    (Venetoclax) Combination Shows Superior Progression-Free Survival Compared to Chlorambucil Plus Obinutuzumab in First-line Chronic Lymphocytic Leukemia (CLL) Phase III GLOW Study

    AbbVie, Inc. announced new data from the Phase III GLOW study comparing the efficacy and safety of the combination of IMBRUVICA® plus VENCLEXTA®/VENCLYXTO® versus chlorambucil plus obinutuzumab for first-line treatment in patients with CLL or small lymphocytic lymphoma who had active disease requiring treatment per the International Workshop on CLL criteria.
    [AbbVie, Inc.]

    Press Release

    FEATURED EVENT

    EMBO Workshop: Lactate Unconventional Roles of a Nutrient Along Tumor Landscape

    June 21 -23, 2021
    Virtual

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    JOB OPPORTUNITIES

    Life Science Research Professional

    Stanford University – Stanford, California, United States

    Research Associate – CNS Stem Cell Culture

    Sana Biotechnology – Seattle, Washington, United States

    Postdoctoral Fellow – Precision Oncology of Gastrointestinal Cancers

    City of Hope – Monrovia, California, United States

    Research Technologist – Neurological Surgery

    Northwestern University – Chicago, Illinois, United States

    Postdoctoral Positions – Hematopoiesis and Leukemia

    UT Southwestern Medical Center – Dallas, Texas, United Statess

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