Cancer Stem Cell News Volume 10.24 | Jun 23 2021


    2021-06-23 | CSCN 10.24

    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 10.24 – 23 June, 2021

    Suppression of Mitochondrial ROS by Prohibitin Drives Glioblastoma Progression and Therapeutic Resistance

    Investigators discovered that prohibitin specifically regulated mitochondrial reactive oxygen species (ROS) production in glioma stem-like cells (GSCs) and facilitated GSC radiotherapeutic resistance.
    [Nature Communications]

    Full Article

    The StemSpan™ T Cell Generation Kit is designed to promote differentiation of HSPCs into T cells in stroma- and serum-free culture conditions.
    PUBLICATIONSRanked by the impact factor of the journal

    Targeting the αv Integrin-TGF-β Axis Improves Natural Killer Cell Function against Glioblastoma Stem Cells

    The authors showed that glioblastoma stem cells, but not normal astrocytes, were sensitive to lysis by healthy allogeneic natural killer cells in vitro.
    [Journal of Clinical Investigation]

    AbstractFull ArticlePress Release

    Graphical Abstract

    SIRT1 Coordinates with the CRL4B Complex to Regulate Pancreatic Cancer Stem Cells to Promote Tumorigenesis

    Scientists demonstrated that SIRT1/CUL4B promoted CSC-like properties, including increased stemness marker expression and sphere formation.
    [Cell Death & Differentiation]

    Full Article

    Polyploid Mitosis and Depolyploidization Promote Chromosomal Instability and Tumor Progression in a Notch-Induced Tumor Model

    Using a Drosophila solid-tumor model where oncogenic Notch drove tumorigenesis in a transition-zone microenvironment in the salivary gland imaginal ring, researchers found that the tumor-initiating cells normally undergo endoreplication to become polyploid.
    [Developmental Cell]

    Full ArticleGraphical Abstract

    E2A Modulates Stemness, Metastasis, and Therapeutic Resistance of Breast Cancer

    Using a combination of in vivo and in vitro analyses in a novel PyMT-E2A conditional knockout mouse model and derived primary tumor cell lines, the authors reported an essential role of E2A in stemness, metastasis, and therapeutic resistance in breast cancer.
    [Cancer Research]


    PCGF1 Promotes Epigenetic Activation of Stemness Markers and Colorectal Cancer Stem Cell Enrichment

    Investigators identified PCGF1 as a crucial epigenetic regulator that sustained the stem cell-like phenotype of colorectal cancer (CRC). PCGF1 knockdown inhibited CRC stem cell proliferation and CRC stem cell enrichment.
    [Cell Death & Disease]

    Full Article

    Exosomal SNHG16 Secreted by CSCs Promotes Glioma Development via TLR7

    The authors suggested CSC-derived exo-SNHG16 promoted cancer progression by activating TLR7/MyD88/NFκB/c-Myc signaling pathway.
    [Stem Cell Research & Therapy]

    Full Article

    Targeting Therapy-Resistant Lung Cancer Stem Cells via Disruption of the AKT/TSPYL5/PTEN Positive-Feedback Loop

    Researchers identified testis-specific Y-like protein 5 (TSPYL5) as an upstream regulator of CSC-associated genes in non-small cell lung cancer cells and suggested this as a therapeutic target for CSC elimination.
    [Communications Biology]

    Full Article

    MicroRNA-17 Is a Tumor Suppressor in Oral Squamous Cell Carcinoma and Is Repressed by LSD1

    The authors investigated whether lysine-specific demethylase 1 (LSD1) affected the development of oral squamous cell carcinoma (OSCC) by sustaining the CSCs from OSCC.
    [Oral Diseases]


    Some Bryophytes Trigger Cytotoxicity of Stem Cell-Like Population in 5-Fluorouracil Resistant Colon Cancer Cells

    Scientists evaluated the effects of Bryophytes like Abietinella abietina, Homolothecium sericeum, Tortella tortuosa, Syntrichia ruralis, and Bryoerythrophyllum rubrum species extracted with ethyl alcohol on 5-fluorouracil resistant colorectal cancer cell lines.
    [Nutrition and Cancer-An International Journal]


    Survey results on the insights and hurdles of CRISPR genome editing.

    Prostate Cancer Cell Heterogeneity and Plasticity: Insights from Studies of Genetically-Engineered Mouse Models

    Investigators discuss recent advances in understanding the cell types of origin, putative CSCs, and tumor plasticity in prostate cancer, focusing on insights from studies of genetically engineered mouse models.
    [Seminars in Cancer Biology]


    Personalized Medicine: Stem Cells in Colorectal Cancer Treatment

    The authors point out the dynamic potential of CSCs and other stem cell types in colorectal cancer (CRC) treatment personalization as well as, in the improvement of current treatment approaches, opting for a higher therapeutic rate, improved prognosis, survival, and quality of life for CRC patients.
    [Biomedicine & Pharmacotherapy]

    AbstractGraphical Abstract

    When Dormancy Fuels Tumor Relapse

    Scientists discuss the implication of dormant cancer cells in tumor relapse and the need to understand how quiescent and senescent cells, respectively, may play a part in this process.
    [Communications Biology]

    Full Article


    Bristol Myers Squibb Receives European Commission Approval for Onureg® (Azacitidine Tablets) as Frontline Oral Maintenance Therapy for Adults with Acute Myeloid Leukemia

    Bristol Myers Squibb announced that the European Commission has granted full Marketing Authorization for Onureg® as a maintenance therapy in adult patients with acute myeloid leukemia who achieved complete remission or complete remission with incomplete blood count recovery following induction therapy.
    [Bristol Myers Squibb]

    Press Release


    European Meeting on Glial Cells and Diseases

    July 5 – 9, 2021

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    Postdoctoral Scientist – Childhood Cancer Research

    Nationwide Children’s Hospital – Columbus, Ohio, United States

    Postdoctoral Research Fellow – Brain Cancer

    Fred Hutchinson Cancer Research Center – Seattle, Washington, United States

    Life Science Research Professional

    Stanford University – Stanford, California, United States

    Research Associate – CNS Stem Cell Culture

    Sana Biotechnology – Seattle, Washington, United States

    Postdoctoral Fellow – Precision Oncology of Gastrointestinal Cancers

    City of Hope – Monrovia, California, United States

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