 | | Vol. 10.24 – 23 June, 2021 |
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| Investigators discovered that prohibitin specifically regulated mitochondrial reactive oxygen species (ROS) production in glioma stem-like cells (GSCs) and facilitated GSC radiotherapeutic resistance.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors showed that glioblastoma stem cells, but not normal astrocytes, were sensitive to lysis by healthy allogeneic natural killer cells in vitro.
[Journal of Clinical Investigation] |
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| Scientists demonstrated that SIRT1/CUL4B promoted CSC-like properties, including increased stemness marker expression and sphere formation.
[Cell Death & Differentiation] |
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| Using a Drosophila solid-tumor model where oncogenic Notch drove tumorigenesis in a transition-zone microenvironment in the salivary gland imaginal ring, researchers found that the tumor-initiating cells normally undergo endoreplication to become polyploid.
[Developmental Cell] |
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| Using a combination of in vivo and in vitro analyses in a novel PyMT-E2A conditional knockout mouse model and derived primary tumor cell lines, the authors reported an essential role of E2A in stemness, metastasis, and therapeutic resistance in breast cancer.
[Cancer Research] |
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| Investigators identified PCGF1 as a crucial epigenetic regulator that sustained the stem cell-like phenotype of colorectal cancer (CRC). PCGF1 knockdown inhibited CRC stem cell proliferation and CRC stem cell enrichment.
[Cell Death & Disease] |
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| The authors suggested CSC-derived exo-SNHG16 promoted cancer progression by activating TLR7/MyD88/NFκB/c-Myc signaling pathway.
[Stem Cell Research & Therapy] |
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| Researchers identified testis-specific Y-like protein 5 (TSPYL5) as an upstream regulator of CSC-associated genes in non-small cell lung cancer cells and suggested this as a therapeutic target for CSC elimination.
[Communications Biology] |
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| The authors investigated whether lysine-specific demethylase 1 (LSD1) affected the development of oral squamous cell carcinoma (OSCC) by sustaining the CSCs from OSCC.
[Oral Diseases] |
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| Scientists evaluated the effects of Bryophytes like Abietinella abietina, Homolothecium sericeum, Tortella tortuosa, Syntrichia ruralis, and Bryoerythrophyllum rubrum species extracted with ethyl alcohol on 5-fluorouracil resistant colorectal cancer cell lines.
[Nutrition and Cancer-An International Journal] |
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| Investigators discuss recent advances in understanding the cell types of origin, putative CSCs, and tumor plasticity in prostate cancer, focusing on insights from studies of genetically engineered mouse models.
[Seminars in Cancer Biology] |
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| The authors point out the dynamic potential of CSCs and other stem cell types in colorectal cancer (CRC) treatment personalization as well as, in the improvement of current treatment approaches, opting for a higher therapeutic rate, improved prognosis, survival, and quality of life for CRC patients.
[Biomedicine & Pharmacotherapy] |
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| Scientists discuss the implication of dormant cancer cells in tumor relapse and the need to understand how quiescent and senescent cells, respectively, may play a part in this process.
[Communications Biology] |
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| Bristol Myers Squibb announced that the European Commission has granted full Marketing Authorization for Onureg® as a maintenance therapy in adult patients with acute myeloid leukemia who achieved complete remission or complete remission with incomplete blood count recovery following induction therapy.
[Bristol Myers Squibb] |
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| | Nationwide Children’s Hospital – Columbus, Ohio, United States |
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| | Fred Hutchinson Cancer Research Center – Seattle, Washington, United States |
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| | Stanford University – Stanford, California, United States |
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| | Sana Biotechnology – Seattle, Washington, United States |
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| | City of Hope – Monrovia, California, United States |
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