 | | Vol. 10.25 – 30 June, 2021 |
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| Investigators showed that super-enhancers played a critical role in the transcription of cancer stemness genes as well as pro-metastatic genes, thereby controlling their tumorigenic potential and metastasis.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors revealed a role for MUC1-C in regulating PBAF, redox balance, and lineage plasticity of prostate cancer stem cell progression.
[Oncogene] |
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| Researchers found that loss of lung cell lineage and gain of stem cell-like characteristics, along with mutator and immune evasion phenotypes, explained the aggressive behavior of a specific subset of lung adenocarcinoma (LUAD) that was called C1-LUAD, including early-stage disease.
[Oncogene] |
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| Scientists found that QAP14 inhibited colony formation, cell motility, mammosphere formation and CSC frequency, induced CSC apoptosis and dopamine D1 receptor expression, and increased cAMP/cGMP levels.
[Acta Pharmacologica Sinica] |
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| The authors presented a single-circulating tumor cell (CTC) sensitive digital droplet PCR assay for the quantitation of the two most common androgen receptor variants (AR-Vs), AR-V7, and AR-v567es, using antigen agnostic CTC enrichment.
[Communications Biology] |
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| Scientists indicated that CSCs may enjoy blood perfusion to maintain their stemness features. Targeting the lysophosphatidic acid/protein kinase D -CD36 signaling pathway may have therapeutic potential to curb tumor progression by disrupting the arteriolar niche and effectively eliminating CSCs.
[Communications Biology] |
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| Pancreatic cancer stem cells (PCSCs) play a key role in the aggressiveness of pancreatic ductal adenocarcinomas; however, little is known about their signaling and metabolic pathways. The authors showed that PCSCs had specific and common proteome and lipidome modulations.
[Scientific Reports] |
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| To determine the prognostic value of the timing of circulating breast tumor cell measurement during treatment, peripheral blood from 164 patients with breast disease was collected.
[Scientific Reports] |
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| Scientists screened stem cells in primary liver cancer cells, analyzed their biological characteristics, and proposed the possibility that liver cancer originated from stem cells.
[Clinical & Translational Oncology] |
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| To improve clinical management of cancer, it is crucial to understand and learn how to manage the close interaction between tumor microenvironment and metastasis.
[Journal of Experimental & Clinical Cancer Research] |
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| Investigators describe different therapeutic strategies such as immunotherapy, metabolism-based therapeutic strategies, and additional potential therapeutic approaches against CSCs.
[IUBMB Life] |
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| Sirnaomics, Inc. has announced dose administration for the first patient in a Phase I US clinical study for liver cancer treatment, with the company’s small interfering RNA drug candidate, STP705.
[Sirnaomics, Inc.] |
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| Syndax Pharmaceuticals, Inc. announced that the FDA has granted Fast Track Designation to SNDX-5613 for the treatment of adult and pediatric patients with relapsed or refractory acute leukemias harboring mixed lineage leukemia rearranged or nucleophosmin mutation. SNDX-5613 is the company’s highly selective, oral menin inhibitor.
[Syndax Pharmaceuticals, Inc.] |
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| September 5 – 8, 2021
Exeter, England, United Kingdom |
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| | Cancer Research UK Beatson Institute – Glasgow, Scotland, United Kingdom |
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| | Cancer Research UK Beatson Institute – Glasgow, Scotland, United Kingdom |
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| | Eastern Virginia Medical School – Norfolk, Virginia, United States |
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| | Nationwide Children’s Hospital – Columbus, Ohio, United States |
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| | Fred Hutchinson Cancer Research Center – Seattle, Washington, United States |
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Cancer Stem Cell News
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