Cancer Stem Cell News Volume 10.25 | Jun 30 2021

2021-06-30 | CSCN 10.25

Cancer Stem Cell News by STEMCELL Technologies
Vol. 10.25 – 30 June, 2021

Transcriptional Super-Enhancers Control Cancer Stemness and Metastasis Genes in Squamous Cell Carcinoma

Investigators showed that super-enhancers played a critical role in the transcription of cancer stemness genes as well as pro-metastatic genes, thereby controlling their tumorigenic potential and metastasis.
[Nature Communications]

Full Article

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MUC1-C Activates the PBAF Chromatin Remodeling Complex in Integrating Redox Balance with Progression of Human Prostate Cancer Stem Cells

The authors revealed a role for MUC1-C in regulating PBAF, redox balance, and lineage plasticity of prostate cancer stem cell progression.

Full Article

Aggressive Early-Stage Lung Adenocarcinoma Is Characterized by Epithelial Cell Plasticity with Acquirement of Stem-Like Traits and Immune Evasion Phenotype

Researchers found that loss of lung cell lineage and gain of stem cell-like characteristics, along with mutator and immune evasion phenotypes, explained the aggressive behavior of a specific subset of lung adenocarcinoma (LUAD) that was called C1-LUAD, including early-stage disease.


QAP14 Suppresses Breast Cancer Stemness and Metastasis via Activation of Dopamine D1 Receptor

Scientists found that QAP14 inhibited colony formation, cell motility, mammosphere formation and CSC frequency, induced CSC apoptosis and dopamine D1 receptor expression, and increased cAMP/cGMP levels.
[Acta Pharmacologica Sinica]


Androgen Receptor Variant Shows Heterogeneous Expression in Prostate Cancer According to Differentiation Stage

The authors presented a single-circulating tumor cell (CTC) sensitive digital droplet PCR assay for the quantitation of the two most common androgen receptor variants (AR-Vs), AR-V7, and AR-v567es, using antigen agnostic CTC enrichment.
[Communications Biology]

Full Article

Development of an Arteriolar Niche and Self-Renewal of Breast Cancer Stem Cells by Lysophosphatidic Acid/Protein Kinase D Signaling

Scientists indicated that CSCs may enjoy blood perfusion to maintain their stemness features. Targeting the lysophosphatidic acid/protein kinase D -CD36 signaling pathway may have therapeutic potential to curb tumor progression by disrupting the arteriolar niche and effectively eliminating CSCs.
[Communications Biology]

Full Article

Integrated Lipidomics and Proteomics Reveal Cardiolipin Alterations, Upregulation of HADHA and Long Chain Fatty Acids in Pancreatic Cancer Stem Cells

Pancreatic cancer stem cells (PCSCs) play a key role in the aggressiveness of pancreatic ductal adenocarcinomas; however, little is known about their signaling and metabolic pathways. The authors showed that PCSCs had specific and common proteome and lipidome modulations.
[Scientific Reports]

Full Article

Circulating Tumor Cells at Baseline and Late Phase of Treatment Provide Prognostic Value in Breast Cancer

To determine the prognostic value of the timing of circulating breast tumor cell measurement during treatment, peripheral blood from 164 patients with breast disease was collected.
[Scientific Reports]

Full Article

Isolated Cancer Stem Cells from Human Liver Cancer: Morphological and Functional Characteristics in Primary Culture

Scientists screened stem cells in primary liver cancer cells, analyzed their biological characteristics, and proposed the possibility that liver cancer originated from stem cells.
[Clinical & Translational Oncology]


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Cancer: A Mirrored Room between Tumor Bulk and Tumor Microenvironment

To improve clinical management of cancer, it is crucial to understand and learn how to manage the close interaction between tumor microenvironment and metastasis.
[Journal of Experimental & Clinical Cancer Research]

Full Article

Selectively Targeting Cancer Stem Cells: Current and Novel Therapeutic Strategies and Approaches in the Effective Eradication of Cancer

Investigators describe different therapeutic strategies such as immunotherapy, metabolism-based therapeutic strategies, and additional potential therapeutic approaches against CSCs.
[IUBMB Life]



Sirnaomics Doses First Patient in Phase 1 Clinical Study of STP705 for Treatment of Liver Cancer

Sirnaomics, Inc. has announced dose administration for the first patient in a Phase I US clinical study for liver cancer treatment, with the company’s small interfering RNA drug candidate, STP705.
[Sirnaomics, Inc.]

Press Release

SNDX-5613 Granted FDA Fast Track Designation for the Treatment of Relapsed/Refractory Acute Leukemias

Syndax Pharmaceuticals, Inc. announced that the FDA has granted Fast Track Designation to SNDX-5613 for the treatment of adult and pediatric patients with relapsed or refractory acute leukemias harboring mixed lineage leukemia rearranged or nucleophosmin mutation. SNDX-5613 is the company’s highly selective, oral menin inhibitor.
[Syndax Pharmaceuticals, Inc.]

Press Release


EMBO Workshop: Long-Distance Cell-Cell Signaling in Development and Disease

September 5 – 8, 2021
Exeter, England, United Kingdom

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Postdoctoral Research Scientist – Colorectal Cancer and Wnt Signaling

Cancer Research UK Beatson Institute – Glasgow, Scotland, United Kingdom

Senior Scientific Officer – Colorectal Cancer

Cancer Research UK Beatson Institute – Glasgow, Scotland, United Kingdom

Research Assistant – Cancer Biology

Eastern Virginia Medical School – Norfolk, Virginia, United States

Postdoctoral Scientist – Childhood Cancer Research

Nationwide Children’s Hospital – Columbus, Ohio, United States

Postdoctoral Research Fellow – Brain Cancer

Fred Hutchinson Cancer Research Center – Seattle, Washington, United States

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