Cancer Stem Cell News Volume 10.28 | Jul 21 2021

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    2021-07-21 | CSCN 10.28


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 10.28 – 21 July, 2021
    TOP STORY

    Nicotinamide Phosphoribosyltransferase Inhibitors Selectively Induce Apoptosis of AML Stem Cells by Disrupting Lipid Homeostasis
    Investigators performed a metabolic drug screen to identify leukemic stem cell (LSC)-specific vulnerabilities and found that nicotinamide phosphoribosyltransferase inhibitors selectively killed LSCs while sparing normal hematopoietic stem and progenitor cells.
    [Cell Stem Cell]
    AbstractGraphical Abstract
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    PUBLICATIONSRanked by the impact factor of the journal

    TEM8 Marks Neovasculogenic Tumor-Initiating Cells in Triple-Negative Breast Cancer
    The authors found that tumor endothelial marker 8 (TEM8) was abundantly expressed in triple-negative breast cancer and served as a marker for vasculogenic mimicry-forming breast tumor-initiating cells.
    [Nature Communications]
    Full Article

    Severe Consequences of a High-Lipid Diet Include Hydrogen Sulfide Dysfunction and Enhanced Aggression in Glioblastoma
    Because the environmental and lifestyle factors that impact CSC populations are not clear, scientists sought to understand the consequences of diet on CSC enrichment.
    [Journal of Clinical Investigation]
    AbstractFull ArticleGraphical Abstract

    Circulating Tumor Cell Copy-Number Heterogeneity in ALK-Rearranged Non-Small-Cell Lung Cancer Resistant to ALK Inhibitors
    Researchers provided an in-depth investigation of copy number alteration heterogeneity in phenotypically characterized circulating tumor cells at resistance to Anaplastic Lymphoma Kinase (ALK)-tyrosine kinase inhibitors in ALK-positive non-small cell lung cancer.
    [npj Precision Oncology]
    Full Article

    Establishment of Oxaliplatin-Resistant Gastric Cancer Organoids: Importance of Myoferlin in the Acquisition of Oxaliplatin Resistance
    Scientists established oxaliplatin resistant gastric cancer organoids and evaluated their gene expression profile using microarray analysis.
    [Gastric Cancer]
    Abstract

    SLC38A4 Functions as a Tumor Suppressor in Hepatocellular Carcinoma through Modulating Wnt/β-Catenin/MYC/HMGCS2 Axis
    Functional assays demonstrated that SLC38A4 depletion promoted hepatocellular carcinoma (HCC) cellular proliferation, stemness, and migration, and inhibited HCC cellular apoptosis in vitro, and further repressed HCC tumorigenesis in vivo.
    [British Journal of Cancer]
    Abstract

    MicroRNA-324-5p-CUEDC2 Axis Mediates Gain-of-Function Mutant p53-Driven Cancer Stemness
    Investigators identified miR-324-5p as a critical epigenetic regulator of cancer stemness and demonstrated its role in mediating gain-of-function -mutant p53-driven stemness phenotype.
    [Molecular Cancer Research]
    Full Article

    The Role of FOSL1 in Stem-Like Cell Reprogramming Processes
    The authors demonstrated that FOSL1 directly regulated four transcription factors bind to their promoter regions was involved in the deregulation of several stemness markers, and reduced the cells’ ability to generate aggregates increasing the extracellular matrix component FN1.
    [Scientific Reports]
    Full Article

    Tumor Stem-Like Cells Isolated from MMQ Cells Resist to Dopamine Agonist Treatment
    Researchers identified a small subset of sphere-forming cells possessed tumor stem-like cell properties in rat prolactinoma MMQ cells, which were resistant to dopamine agonist treatment.
    [Molecular and Cellular Endocrinology]
    Abstract

    RAB27A-Dependent Release of Exosomes by Liver Cancer Stem Cells Induces Nanog Expression in Their Differentiated Progenies and Confers Regorafenib Resistance
    Scientists investigated the Regorafenib resistance mechanism of CSCs in hepatocellular carcinoma. They used sphere formation and soft agar colony formation assays to evaluate the stemness capacity of cancer cells.
    [Journal of Gastroenterology and Hepatology]
    Abstract

    NANOG Gene Suppression and Replacement of Let-7 Modulate the Stemness, Invasion, and Apoptosis in Breast Cancer
    Researchers evaluated the NANOG inhibition by siRNA and the increase of Let-7a by miRNA mimic in breast cancer cell lines and the effects of these changes on biologic aspects like apoptosis, stemness, and invasion of these cells.
    [Gene]
    Abstract
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    REVIEWS

    Therapeutic Perspective of Temozolomide Resistance in Glioblastoma Treatment
    The authors summarize the temozolomide (TMZ)-resistance mechanisms and discuss several potential therapies from conservative opinion of glioma stem cell-targeted therapy orientation to current view of TMZ resistance-aimed efficacy.
    [Cancer Investigation]
    Abstract
    INDUSTRY AND POLICY NEWS

    Oblato Announces That It Has Received a Positive Response from the FDA for the Use of OKN-007 for Patients with High-grade Gliomas in an Expanded Access Program
    Oblato, Inc. announced that it has received an agreement from the FDA for its plan to submit an intermediate size expanded access protocol for use of OKN-007 in patients with high-grade gliomas.
    [Oblato, Inc.]
    Press Release

    Lava Therapeutics Announces Treatment of First Patient in Phase I/IIa Clinical Trial of LAVA-051 for Multiple Hematological Malignancies
    LAVA Therapeutics N.V. announced the dosing of the first patient in the company’s Phase I/IIa clinical trial of LAVA-051 in patients with relapsed and/or refractory chronic lymphocytic leukemia, multiple myeloma, and acute myeloid leukemia.
    [LAVA Therapeutics, N.V.]
    Press Release
    FEATURED EVENT

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    October 28 – 29, 2021
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    JOB OPPORTUNITIES

    Postdoctoral Position – Leukemia
    Princess Margaret Cancer Centre – Toronto, Ontario, United States

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    Medical University of South Carolina – Charleston, South Carolina, United States

    Research Associate – Cancer Stem Cell Biology
    UC San Diego School of Medicine – San Diego, California, United States

    Postdoctoral Researcher – Stem Cells, Organoids, and Systems Biology
    Medical College of Wisconsin – Milwaukee, Wisconsin, United States

    Postdoctoral Associate – Anti-Cancer Nanorings
    University of Minnesota, Twin Cities – Minneapolis, Minnesota, United States

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