Cancer Stem Cell News Volume 10.29 | Jul 28 2021


    2021-07-28 | CSCN 10.29

    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 10.29 – 28 July, 2021

    Afatinib Induces Pro-Survival Autophagy and Increases Sensitivity to Apoptosis in Stem-Like HNSCC Cells

    Scientists demonstrated that afatinib induced mTORC1 suppression-mediated autophagy in head and neck squamous cell carcinoma cells.
    [Cell Death & Disease]

    Full Article
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    PUBLICATIONSRanked by the impact factor of the journal

    Elevated Cellular PpIX Potentiates Sonodynamic Therapy in a Mouse Glioma Stem Cell-Bearing Glioma Model by Downregulating the Akt/NF-κB/MDR1 Pathway

    In high invasive progeny cells from mouse glioma stem cells (GSCs) and a GSC-bearing mouse glioma model, researchers assessed the anti-tumor effects of sonodynamic therapy with a COX-2 inhibitor, celecoxib.
    [Scientific Reports]

    Full Article

    Nuclear NAD+ Homeostasis Governed by NMNAT1 Prevents Apoptosis of Acute Myeloid Leukemia Stem Cells

    Scientists demonstrated that NAD+ metabolism enabled acute myeloid leukemia (AML) to evade apoptosis. They integrated whole-genome CRISPR screening and pan-cancer genetic dependency mapping to identify NAMPT and NMNAT1 as AML dependencies governing NAD+ biosynthesis.
    [Science Advances]

    Full Article

    Targeting Cancer Stem Cells in Medulloblastoma by Inhibiting AMBRA1 Dual Function in Autophagy and STAT3 Signaling

    Investigators identified a previously unrecognized role of the pro-autophagy factor AMBRA1 in regulating medulloblastoma .
    [Acta Neuropathologica]

    Full Article

    Human Prostate Epithelial Cells and Prostate-Derived Stem Cells Malignantly Transformed In Vitro with Sodium Arsenite Show Impaired Toll Like Receptor -3 (TLR3)-Associated Anti-Tumor Pathway

    Researchers evaluated TLR3-mediated activation of anti-tumor pathway based in RARβ expression, on As-CSC and iAs-transformed epithelial cells (CAsE-PE)
    [Toxicology Letters]

    AbstractGraphical Abstract

    ETV7 Regulates Breast Cancer Stem-Like Cell Features by Repressing IFN-Response Genes

    Scientists showed a new role for ETV7, a transcriptional repressor member of the ETS family, in promoting breast cancer stem-like cells plasticity and resistance to chemo- and radiotherapy in breast cancer cells.
    [Cell Death & Disease]

    Full Article

    Aspirin Enhances the Therapeutic Efficacy of Cisplatin in Oesophageal Squamous Cell Carcinoma by Inhibition of Putative Cancer Stem Cells

    The authors investigated the role of acetylsalicylic acid in chemotherapy/chemoprevention in human oesophageal squamous cell carcinoma (ESCC) cell lines and an N-nitrosomethylbenzylamine-induced rat ESCC carcinogenesis model.
    [British Journal of Cancer]

    Full Article

    Autophagy Inhibition Reinforces Stemness Together with Exit from Dormancy of Polydisperse Glioblastoma Stem Cells

    Scientists silenced two autophagy related genes -either Beclin1 or ATG5- by shRNA and they explored the ensuing consequences on CSCs markers’ expression and functionalities.


    Mutant p53 Attenuates Oxidative Phosphorylation and Facilitates Cancer Stemness through Downregulating microRNA-200c-PCK2 Axis in Basal-Like Breast Cancer

    Investigators demonstrated that CRISPR-mediated knockout of miR-200c induced metabolic features similar to the metabolic rewiring caused by p53 hot-spot mutations, and that impairing this metabolic reprogramming interfered with miR-200c deficiency-induced stemness and transformation.
    [Molecular Cancer Research]

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    Catch Me If You Can: How AML and Its Niche Escape Immunotherapy

    The authors describe the immunological features of the acute myeloid leukemia (AML) niche, with particular attention to the crosstalk between the AML blasts and the cellular components of the altered tumor microenvironment and the mechanisms of immune escape that hamper the therapeutic effects of the most advanced treatments.


    Eureka Therapeutics Announces Initiation of Phase I/II ARYA-3 Clinical Trial of GPC3 Targeting ARTEMIS® T Cell Therapy in Liver Cancer

    Eureka Therapeutics, Inc. announced the initiation of a Phase I/II clinical trial of ECT204, a glypican 3 (GPC3) targeting ARTEMIS® T-cell therapy for the treatment of hepatocellular carcinoma, the predominant type of liver cancer.
    [Eureka Therapeutics, Inc.]

    Press Release

    Kronos Bio Announces FDA Clearance of Investigational New Drug Application for Lanraplenib (LANRA) for Treatment of Patients with Acute Myeloid Leukemia (AML)

    Kronos Bio, Inc. announced the US FDA has cleared its Investigational New Drug Application for LANRA, allowing the company to proceed with a Phase I/II clinical trial of LANRA in patients with relapsed or refractory FLT3-mutated AML in combination with gilteritinib.
    [Kronos Bio, Inc.]

    Press Release

    State Gives $51 Million to College Students for Stem Cell Research

    The California stem cell agency awarded $51 million to help train students in the art of research at the Golden State’s community colleges and universities.
    [Capitol Weekly]

    Press Release

    EMBO Workshop: Cancer Immunometabolism

    November 29 – December 1, 2021
    Barcelona, Spain

    Postdoctoral Fellow – Cancer Genomics and Liquid Biopsies

    University of Gothenburg – Gothenburg, Sweden

    Assistant Professor – Translational Metabolism

    Dalhousie University – Halifax, Nova Scotia, Canada

    Research Associate – Cancer Research Experimental Therapies

    Cedars-Sinai – Los Angeles, California, United States

    Postdoctoral Position – Leukemia

    Princess Margaret Cancer Centre – Toronto, Ontario, United States

    Postdoctoral Researcher – Stem Cells, Organoids, and Systems Biology

    Medical College of Wisconsin – Milwaukee, Wisconsin, United States

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