Cancer Stem Cell News Volume 10.33 | Aug 25 2021


    2021-08-33 | CSCN 10.33

    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 10.33 – 25 August, 2021

    hsa_circ_0003222 Accelerates Stemness and Progression of Non-Small Cell Lung Cancer by Sponging miR-527

    Researchers investigated the combined influence of CSCs, circRNA, and immune checkpoint inhibitors in non-small cell lung cancerprogression and therapy resistance. They constructed lung CSCs.
    [Cell Death & Disease]

    Full Article
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    BEX2 Is Required for Maintaining Dormant Cancer Stem Cell in Hepatocellular Carcinoma

    Scientists showed that brain expressed X-linked gene 2(BEX2), which is essential for dormant CSCs in cholangiocarcinoma, was highly expressed in human hepatocellular carcinoma (HCC) lesions compared to the adjacent normal lesions, and that in 41 HCC cases the BEX2high expression group was correlated with a poor prognosis.
    [Cancer Science]


    Purinergic Receptor P2Y6 Is a Negative Regulator of NK Cell Maturation and Function

    The authors discovered that the expression of P2Y6 was decreased upon the activation of the NK cells. In the P2Y6-deficient mice, they found that the deficiency of P2Y6 promoted the development of the NK precursor cells into immature NK and mature NK cells.
    [Journal of Immunology]


    Ethanol-Based Garlic Extract Prevents Malignant Evolution of Non-Invasive Breast Tumor Cells Induced by Moderate Hypoxia

    Homemade ethanol-based garlic extract was administered to MCF7 and MCF10DCIS breast tumor cell lines grown under moderate hypoxia. Cell cycle, epithelial-to-mesenchymal transition and cancer stem cell markers were evaluated.
    [Biomedicine & Pharmacotherapy]

    AbstractGraphical Abstract

    Translocation of Intracellular CD24 Constitutes a Triggering Event for Drug Resistance in Breast Cancer

    Scientists evaluated the phenotype switching associated with drug resistance in breast cancer cell lines and cell lineage obtained from Brazilian patients and highlighted the role of the cancer stem cell marker CD24 in the dynamics of cell plasticity and the acquirement of drug resistance.
    [Scientific Reports]

    Full Article

    Up-Regulation of miR-663a Inhibits the Cancer Stem Cell-Like Properties of Glioma via Repressing the KDM2A-Mediated TGF-β/SMAD Signaling Pathway

    Investigators explored the role and underlying mechanism of miR-663a in the proliferation, migration, invasion, and CSC-like properties of glioma cells.
    [Cell Cycle]


    Effect of Aerobic Exercise on Acquired Gefitinib Resistance in Lung Adenocarcinoma

    Scientists successfully established lung adenocarcinoma cell lines with gefitinib resistance. Long-term gefitinib induction could increase the level of oxidative stress in lung adenocarcinoma cells and reduce the antioxidant capacity, resulting in the high expression of HIF-1 and ALDH1 and leading to the enrichment of CSCs, and a decreased response to gefitinib.
    [Translational Oncology]

    Full Article

    Faciogenital Dysplasia 5 Confers the Cancer Stem Cell-Like Traits of Gastric Cancer Cells through Enhancing Sox2 Protein Stability

    Faciogenital dysplasia 5 (FGD5) was knocked down in gastric cancer cell lines through two independent siRNAs against FGD5 and it was identified that FGD5 knockdown suppressed the CSC—like traits of gastric cancer cells through analyzing the expression of CSC markers, ALDH1 activity and spheroid-formation ability.
    [Environmental Toxicology]


    Colon Adenocarcinoma-Derived Cells Possessing Stem Cell Function Can Be Modulated Using Renin-Angiotensin System Inhibitors

    Primary cell lines derived from four high-grade colon adenocarcinoma tissues were treated with renin-angiotensin system inhibitors to investigate their effect on cellular metabolism, tumorsphere formation and transcription of pluripotency genes.
    [PLoS One]

    Full Article
    Survey results on the needs and challenges in the human pluripotent stem cell field

    Using Single-Cell Sequencing Technology to Detect Circulating Tumor Cells in Solid Tumors

    Investigators describe the identification, biological characteristics, and single-cell genome-wide variation in circulating tumor cells and summarizes the application of single-cell sequencing technology to tumor typing, metastasis analysis, progression detection, and adjuvant therapy.
    [Molecular Cancer]

    Full Article

    Elucidating the Mechanisms of Temozolomide Resistance in Gliomas and the Strategies to Overcome the Resistance

    The authors summarize different strategies that intensify the temozolomide effect such as MGMT inhibition, development of novel imidazotetrazine analog, and combination therapy; with an aim to incorporate a successful treatment and increased overall survival in glioblastoma patients.
    [Biochimica et Biophysica Acta-Reviews On Cancer]


    Samyang Biopharm USA and Dr. Hyun-Sung Lee, Baylor College of Medicine Announce Strategic Collaboration to Study the Effects of SYB-010 On Overcoming Resistance to Immune Checkpoint Therapy

    Samyang Biopharm USA, Inc. global biotech subsidiary of the Samyang Holdings Pharmaceuticals Corp. announced today that the company has entered into a three-year research collaboration with Dr. Hyun-Sung Lee, Assistant Professor of Surgery and Director of the Systems Onco-Immunology Laboratory at Baylor College of Medicine.
    [Samyang Biopharm USA, Inc. (BusinessWire, Inc.)]

    Press Release

    Bio-Path Holdings Announces Clearance of Investigational New Drug Application for BP1002 in Refractory/Relapsed Acute Myeloid Leukemia Patients

    Bio-Path Holdings, Inc. announced that the US FDA has reviewed and cleared the Investigational New Drug application for BP1002, the company’s second drug candidate, for an initial Phase I/Ib clinical trial that will evaluate the ability of BP1002 to treat refractory/relapsed acute myeloid leukemia patients.
    [Bio-Path Holdings, Inc.]

    Press Release

    Translational Immunology

    November 22 – 23, 2021
    Ghent, Belgium

    > See All Events


    Postdoctoral Fellow – Normal and Leukemic Hematopoietic Stem Cells

    Indiana University – Indianapolis, Indiana, United States

    Postdoctoral Fellow – Normal and Leukemic Hematopoietic Stem Cells

    Indiana University – Indianapolis, Indiana, United States

    Research Fellow – Cancer Immunology and Stem Cells Research

    Dana-Farber Cancer Institute- Boston, Massachusetts, United States

    Faculty Position – Cancer Biology and Signal Transduction

    Purdue University – West Lafayette, Indiana, United States

    Principal Medical Scientist – Oncology

    Gilead Sciences, Inc. – Foster City, California, United States

    > See All Jobs

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