Cancer Stem Cell News Volume 10.35 | Sep 8 2021

2021-09-08 | CSCN 10.35

Cancer Stem Cell News by STEMCELL Technologies
Vol. 10.35 – 8 September, 2021

Cilium Induction Triggers Differentiation of Glioma Stem Cells

Investigators showed that patient-derived glioma-stem cells recruited elevated levels of proteins that ensured the temporal cilium disassembly, leading to suppressed ciliogenesis.
[Cell Reports]

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Tumor-Initiating Stem Cell Shapes Its Microenvironment into an Immunosuppressive Barrier and Pro-Tumorigenic Niche

Using DNA-label retaining, single-cell RNA sequencing, and other approaches, researchers investigated intestinal adenoma in response to chemoradiotherapy, thus identifying therapy-resistant tumor-initiating stem cells.
[Cell Reports]

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LGR6 Activates the Wnt/β-Catenin Signaling Pathway and Forms a β-Catenin/TCF7L2/LGR6 Feedback Loop in LGR6high Cervical Cancer Stem Cells

By analyzing The Cancer Genome Atlas database, the leucine-rich repeat-containing G-protein-coupled receptor 6 (LGR6) was found to be correlated with a poor prognosis of cervical cancer.

Full Article

Microfluidic Tandem Mechanical Sorting System for Enhanced Cancer Stem Cell Isolation and Ingredient Screening

A microfluidic tandem mechanical sorting system was developed to enrich CSCs with high flexibility and low adhesive capacity.
[Advanced Healthcare Materials]


Nanoparticle-Mediated Specific Elimination of Soft Cancer Stem Cells by Targeting Low Cell Stiffness

Scientists reported that breast CSCs exhibited much lower stiffness but considerably higher uptake of nitrogen-doped graphene quantum dots than bulk tumor cells.
[Acta Biomaterialia]

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Sulfarotene, a Synthetic Retinoid, Overcomes Stemness and Sorafenib Resistance of Hepatocellular Carcinoma via Suppressing SOS2-RAS Pathway

Researchers evaluated the pharmacology and mechanism of sulfarotene, a new type of synthetic retinoid, on the CSC-like properties of hepatocellular carcinoma (HCC) tumor-repopulating cells, and assessed its preclinical efficacy in models of HCC patient-derived xenografts
[Journal of Experimental & Clinical Cancer Research]

Full Article

Downregulated CLIP3 Induces Radioresistance by Enhancing Stemness and Glycolytic Flux in Glioblastoma

Patient-derived glioma stem-like cells, glioblastoma (GBM) cell lines, intracranial GBM xenografts, and GBM sections were used to measure mRNA and protein expression and determine the related molecular mechanisms by qRT-PCR, immunoblot, immunoprecipitation, immunofluorescence, OCR, ECAR, live-cell imaging, and immunohistochemistry.
[Journal of Experimental & Clinical Cancer Research]

Full Article

Characterization of Glioblastoma Cancer Stem Cells Sorted by Sedimentation Field-Flow Fractionation Using an Ultrahigh-Frequency Range Dielectrophoresis Biosensor

Investigators demonstrated the capability of using an ultrahigh-frequency range dielectrophoresis fluidic biosensor as a detector. This implied an important methodological adaptation of sedimentation field-flow fractionation cell sorting by the use of a new compatible carrier liquid DEP buffer.
[Analytical Chemistry]

AbstractGraphical Abstract

MicroRNA-148a/152 Cluster Restrains Tumor Stem Cell Phenotype of Colon Cancer via Modulating CCT6A

Colon CSCs were selected and high/low expression of miR-148a/152 plasmids were synthesized to intervene CD44+/CD133+ colon CSCs to investigate the function of miR-148a/152 in invasion, migration, proliferation, colony formation and apoptosis of cells.
[Anti-Cancer Drugs]

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Cell Plasticity, Senescence, and Quiescence in Cancer Stem Cells: Biological and Therapeutic Implications

The authors integrated the recent advances and current knowledge to elucidate the mechanisms involved in the regulation of plasticity, senescence and quiescence of CSCs and the potential therapeutic implications for the future.
[Pharmacology & Therapeutics]


The Metabolic Flexibility of Quiescent CSC: Implications for Chemotherapy Resistance

Scientists focus on the roles of metabolic flexibility and the tumor microenvironment (TME) on CSCs quiescence and further discuss potential treatments of targeting CSCs and the TME to limit chemotherapy resistance.
[Cell Death & Disease]

Full Article

Translational Models of 3-D Organoids and Cancer Stem Cells in Gastric Cancer Research

Investigators develop precise culture conditions for gastric organoids in vitro to improve the accuracy of the generation of organoid models for therapeutic and medical applications.
[Stem Cell Research & Therapy]

Full Article

UCSF Radiology and Radiation Oncology Researchers Join Forces to Study HP 13C MRI in Prostate Cancer Undergoing Radiation Therapy

Two faculty members in the UC San Francisco Department of Radiology and Biomedical Imaging recently received funding from National Institutes of Health/National Cancer Institute for an exciting research project to study hyperpolarized carbon-13 metabolic MRI in prostate cancer patients undergoing radiation therapy.
[UCSF (Department of Radiology & Biomedical Imaging)]

Press Release

Candel Therapeutics Completes Enrollment in Phase III Clinical Trial of CAN-2409 in Combination with Valacyclovir for the Treatment of Intermediate-High Risk Localized Prostate Cancer

Candel Therapeutics, Inc. announced that it has completed patient enrollment for its pivotal Phase III study of CAN-2409 immunotherapy in patients with intermediate-high risk localized prostate cancer.
[Candel Therapeutics, Inc.]

Press Release

New Grant Awarded to MSK for Efforts in Acute Myeloid Leukemia Research

Memorial Sloan Kettering Cancer Center has received a major grant from the US National Institutes of Health to conduct research related to leukemia.
[Memorial Sloan Kettering Cancer Center]

Press Release

The NYSCF Conference – New York Stem Cell Foundation

October 19 – 20, 2021

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PhD Student – Tumor Immunology

University Hospital of Bern – Bern, Switzerland

Senior Researcher – Genomic and Epigenetic Changes of Rare Tumors

St. Jude Children’s Research Hospital – Memphis, Tennessee, United States

Faculty Positions – Cancer Research

Sidney Kimmel Cancer Center at Jefferson Health – Philadelphia, Pennsylvania, United States

Research Associate – Senescence in Lung Tumor

University of Cambridge – Cambridge, England, United Kingdom

Postdoctoral Fellow – Normal and Leukemic Hematopoietic Stem Cells

Indiana University – Indianapolis, Indiana, United States

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