 | | Vol. 10.35 – 8 September, 2021 |
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| Investigators showed that patient-derived glioma-stem cells recruited elevated levels of proteins that ensured the temporal cilium disassembly, leading to suppressed ciliogenesis.
[Cell Reports] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Using DNA-label retaining, single-cell RNA sequencing, and other approaches, researchers investigated intestinal adenoma in response to chemoradiotherapy, thus identifying therapy-resistant tumor-initiating stem cells.
[Cell Reports] |
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| By analyzing The Cancer Genome Atlas database, the leucine-rich repeat-containing G-protein-coupled receptor 6 (LGR6) was found to be correlated with a poor prognosis of cervical cancer.
[Oncogene] |
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| A microfluidic tandem mechanical sorting system was developed to enrich CSCs with high flexibility and low adhesive capacity.
[Advanced Healthcare Materials] |
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| Scientists reported that breast CSCs exhibited much lower stiffness but considerably higher uptake of nitrogen-doped graphene quantum dots than bulk tumor cells.
[Acta Biomaterialia] |
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| Researchers evaluated the pharmacology and mechanism of sulfarotene, a new type of synthetic retinoid, on the CSC-like properties of hepatocellular carcinoma (HCC) tumor-repopulating cells, and assessed its preclinical efficacy in models of HCC patient-derived xenografts
[Journal of Experimental & Clinical Cancer Research] |
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| Patient-derived glioma stem-like cells, glioblastoma (GBM) cell lines, intracranial GBM xenografts, and GBM sections were used to measure mRNA and protein expression and determine the related molecular mechanisms by qRT-PCR, immunoblot, immunoprecipitation, immunofluorescence, OCR, ECAR, live-cell imaging, and immunohistochemistry.
[Journal of Experimental & Clinical Cancer Research] |
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| Investigators demonstrated the capability of using an ultrahigh-frequency range dielectrophoresis fluidic biosensor as a detector. This implied an important methodological adaptation of sedimentation field-flow fractionation cell sorting by the use of a new compatible carrier liquid DEP buffer.
[Analytical Chemistry] |
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| Colon CSCs were selected and high/low expression of miR-148a/152 plasmids were synthesized to intervene CD44+/CD133+ colon CSCs to investigate the function of miR-148a/152 in invasion, migration, proliferation, colony formation and apoptosis of cells.
[Anti-Cancer Drugs] |
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| The authors integrated the recent advances and current knowledge to elucidate the mechanisms involved in the regulation of plasticity, senescence and quiescence of CSCs and the potential therapeutic implications for the future.
[Pharmacology & Therapeutics] |
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| Scientists focus on the roles of metabolic flexibility and the tumor microenvironment (TME) on CSCs quiescence and further discuss potential treatments of targeting CSCs and the TME to limit chemotherapy resistance.
[Cell Death & Disease] |
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| Investigators develop precise culture conditions for gastric organoids in vitro to improve the accuracy of the generation of organoid models for therapeutic and medical applications.
[Stem Cell Research & Therapy] |
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| Two faculty members in the UC San Francisco Department of Radiology and Biomedical Imaging recently received funding from National Institutes of Health/National Cancer Institute for an exciting research project to study hyperpolarized carbon-13 metabolic MRI in prostate cancer patients undergoing radiation therapy.
[UCSF (Department of Radiology & Biomedical Imaging)] |
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| Candel Therapeutics, Inc. announced that it has completed patient enrollment for its pivotal Phase III study of CAN-2409 immunotherapy in patients with intermediate-high risk localized prostate cancer.
[Candel Therapeutics, Inc.] |
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| Memorial Sloan Kettering Cancer Center has received a major grant from the US National Institutes of Health to conduct research related to leukemia.
[Memorial Sloan Kettering Cancer Center] |
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| October 19 – 20, 2021
Virtual |
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| | University Hospital of Bern – Bern, Switzerland |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | Sidney Kimmel Cancer Center at Jefferson Health – Philadelphia, Pennsylvania, United States |
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| University of Cambridge – Cambridge, England, United Kingdom |
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| | Indiana University – Indianapolis, Indiana, United States |
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