Cancer Stem Cell News Volume 10.35 | Sep 8 2021


    2021-09-08 | CSCN 10.35

    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 10.35 – 8 September, 2021

    Cilium Induction Triggers Differentiation of Glioma Stem Cells

    Investigators showed that patient-derived glioma-stem cells recruited elevated levels of proteins that ensured the temporal cilium disassembly, leading to suppressed ciliogenesis.
    [Cell Reports]

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    Tumor-Initiating Stem Cell Shapes Its Microenvironment into an Immunosuppressive Barrier and Pro-Tumorigenic Niche

    Using DNA-label retaining, single-cell RNA sequencing, and other approaches, researchers investigated intestinal adenoma in response to chemoradiotherapy, thus identifying therapy-resistant tumor-initiating stem cells.
    [Cell Reports]

    Full ArticleGraphical Abstract

    LGR6 Activates the Wnt/β-Catenin Signaling Pathway and Forms a β-Catenin/TCF7L2/LGR6 Feedback Loop in LGR6high Cervical Cancer Stem Cells

    By analyzing The Cancer Genome Atlas database, the leucine-rich repeat-containing G-protein-coupled receptor 6 (LGR6) was found to be correlated with a poor prognosis of cervical cancer.

    Full Article

    Microfluidic Tandem Mechanical Sorting System for Enhanced Cancer Stem Cell Isolation and Ingredient Screening

    A microfluidic tandem mechanical sorting system was developed to enrich CSCs with high flexibility and low adhesive capacity.
    [Advanced Healthcare Materials]


    Nanoparticle-Mediated Specific Elimination of Soft Cancer Stem Cells by Targeting Low Cell Stiffness

    Scientists reported that breast CSCs exhibited much lower stiffness but considerably higher uptake of nitrogen-doped graphene quantum dots than bulk tumor cells.
    [Acta Biomaterialia]

    AbstractGraphical Abstract

    Sulfarotene, a Synthetic Retinoid, Overcomes Stemness and Sorafenib Resistance of Hepatocellular Carcinoma via Suppressing SOS2-RAS Pathway

    Researchers evaluated the pharmacology and mechanism of sulfarotene, a new type of synthetic retinoid, on the CSC-like properties of hepatocellular carcinoma (HCC) tumor-repopulating cells, and assessed its preclinical efficacy in models of HCC patient-derived xenografts
    [Journal of Experimental & Clinical Cancer Research]

    Full Article

    Downregulated CLIP3 Induces Radioresistance by Enhancing Stemness and Glycolytic Flux in Glioblastoma

    Patient-derived glioma stem-like cells, glioblastoma (GBM) cell lines, intracranial GBM xenografts, and GBM sections were used to measure mRNA and protein expression and determine the related molecular mechanisms by qRT-PCR, immunoblot, immunoprecipitation, immunofluorescence, OCR, ECAR, live-cell imaging, and immunohistochemistry.
    [Journal of Experimental & Clinical Cancer Research]

    Full Article

    Characterization of Glioblastoma Cancer Stem Cells Sorted by Sedimentation Field-Flow Fractionation Using an Ultrahigh-Frequency Range Dielectrophoresis Biosensor

    Investigators demonstrated the capability of using an ultrahigh-frequency range dielectrophoresis fluidic biosensor as a detector. This implied an important methodological adaptation of sedimentation field-flow fractionation cell sorting by the use of a new compatible carrier liquid DEP buffer.
    [Analytical Chemistry]

    AbstractGraphical Abstract

    MicroRNA-148a/152 Cluster Restrains Tumor Stem Cell Phenotype of Colon Cancer via Modulating CCT6A

    Colon CSCs were selected and high/low expression of miR-148a/152 plasmids were synthesized to intervene CD44+/CD133+ colon CSCs to investigate the function of miR-148a/152 in invasion, migration, proliferation, colony formation and apoptosis of cells.
    [Anti-Cancer Drugs]

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    Cell Plasticity, Senescence, and Quiescence in Cancer Stem Cells: Biological and Therapeutic Implications

    The authors integrated the recent advances and current knowledge to elucidate the mechanisms involved in the regulation of plasticity, senescence and quiescence of CSCs and the potential therapeutic implications for the future.
    [Pharmacology & Therapeutics]


    The Metabolic Flexibility of Quiescent CSC: Implications for Chemotherapy Resistance

    Scientists focus on the roles of metabolic flexibility and the tumor microenvironment (TME) on CSCs quiescence and further discuss potential treatments of targeting CSCs and the TME to limit chemotherapy resistance.
    [Cell Death & Disease]

    Full Article

    Translational Models of 3-D Organoids and Cancer Stem Cells in Gastric Cancer Research

    Investigators develop precise culture conditions for gastric organoids in vitro to improve the accuracy of the generation of organoid models for therapeutic and medical applications.
    [Stem Cell Research & Therapy]

    Full Article

    UCSF Radiology and Radiation Oncology Researchers Join Forces to Study HP 13C MRI in Prostate Cancer Undergoing Radiation Therapy

    Two faculty members in the UC San Francisco Department of Radiology and Biomedical Imaging recently received funding from National Institutes of Health/National Cancer Institute for an exciting research project to study hyperpolarized carbon-13 metabolic MRI in prostate cancer patients undergoing radiation therapy.
    [UCSF (Department of Radiology & Biomedical Imaging)]

    Press Release

    Candel Therapeutics Completes Enrollment in Phase III Clinical Trial of CAN-2409 in Combination with Valacyclovir for the Treatment of Intermediate-High Risk Localized Prostate Cancer

    Candel Therapeutics, Inc. announced that it has completed patient enrollment for its pivotal Phase III study of CAN-2409 immunotherapy in patients with intermediate-high risk localized prostate cancer.
    [Candel Therapeutics, Inc.]

    Press Release

    New Grant Awarded to MSK for Efforts in Acute Myeloid Leukemia Research

    Memorial Sloan Kettering Cancer Center has received a major grant from the US National Institutes of Health to conduct research related to leukemia.
    [Memorial Sloan Kettering Cancer Center]

    Press Release

    The NYSCF Conference – New York Stem Cell Foundation

    October 19 – 20, 2021

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    PhD Student – Tumor Immunology

    University Hospital of Bern – Bern, Switzerland

    Senior Researcher – Genomic and Epigenetic Changes of Rare Tumors

    St. Jude Children’s Research Hospital – Memphis, Tennessee, United States

    Faculty Positions – Cancer Research

    Sidney Kimmel Cancer Center at Jefferson Health – Philadelphia, Pennsylvania, United States

    Research Associate – Senescence in Lung Tumor

    University of Cambridge – Cambridge, England, United Kingdom

    Postdoctoral Fellow – Normal and Leukemic Hematopoietic Stem Cells

    Indiana University – Indianapolis, Indiana, United States

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