 | | Vol. 10.43 – 3 November, 2021 |
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| Researchers highlighted that lncROPM and its target PLA2G16 played crucial roles in sustaining breast CSC (BCSC) properties and might serve as a biomarker for BCSCs or other cancer stem cells.
[Journal of Hematology & Oncology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists found a set of hormone-responsive lineage-specific transcription factors, FOXA1, GATA3, ERα, directly drove high expression of arylsulfatase D (ARSD) through chromatin looping in luminal subtype breast cancer cells.
[Cell Death & Disease] |
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| The PERK pathway inhibited global protein synthesis while allowing translation of specific mRNAs, such as the ATF4 transcription factor.
[Cell Death & Disease] |
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| Researchers demonstrated that KIT was a downstream effector of TCOF1 in mediating triple-negative breast cancer stemness.
[British Journal of Cancer] |
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| Investigators applied droplet-based single-cell RNA sequencing to acquire transcriptional profiles of 36 619 single cells isolated from seven patients.
[International Journal of Cancer] |
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| Scientists carried out systematic analyses of metabolites in patient-derived colorectal cancer spheroids, and identified high levels of kynurenine and TDO2 that were positively associated with liver metastasis.
[Cancer Science] |
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| The authors investigated the role of ASAP1 Intronic Transcript 1 (ASAP1-IT1) in cancer cell stemness of non-small cell lung cancer.
[Cancer Cell International] |
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| Scientists developed a culture system regulating culture temperature immediately and accurately by employing metallic culture vessels. Michigan Cancer Foundation-7 cells and normal human dermal fibroblasts were used for models of cancer and normal cells.
[Scientific Reports] |
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| SOX12 plays a role in promoting the growth of some tumors; however, its role in osteosarcoma remains unclear. Researchers performed in vitro and in vivo assays to determine SOX12 function in osteosarcoma etiology.
[Stem Cells International] |
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| The interaction between cancer cells and platelets was examined in 15 epithelial cell lines, representing 7 cancer types. Gene expression analysis of epithelial mesenchymal transition-associated and cancer stemness genes was performed by RT-PCR.
[Translational Oncology] |
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| Scientists discuss the integrin signalosome with a highlight of a few key pro-oncogenic pathways elicited by integrins, and uncover the mutational and transcriptomic landscape of integrin-encoding genes across human cancers.
[Journal of Hematology & Oncology] |
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| The authors review recent literature on energy production in glioblastoma stem cells and leukemic stem cells versus their normal counterparts, neural stem cells and hematopoietic stem cells, respectively.
[Journal of Histochemistry & Cytochemistry] |
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| Sorrento Therapeutics, Inc. has submitted a NDA for the anti-PD-L1 antibody, socazolimab, licensed from Sorrento to China Oncology Focus, Ltd. for the greater China territory to treat recurrent or metastatic cervical cancer. The NDA application has been accepted by China NMPA.
[Sorrento Therapeutics, Inc.] |
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| November 15 – 17, 2021
Virtual |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| The University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
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| | Cedars-Sinai Medical Center – Los Angeles, California, United States |
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| | Cancer Research UK Manchester Institute – Manchester, United Kingdom |
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| University of California Los Angeles – Los Angeles, California, United States |
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