Cancer Stem Cell News Volume 10.44 | Nov 10 2021

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    2021-11-10 | CSCN 10.44


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 10.44 – 10 November, 2021
    TOP STORY

    Expression of GALNT8 and O-glycosylation of BMP Receptor 1A Suppress Breast Cancer Cell Proliferation by Upregulating ERα Levels
    Immunofluorescence, immunoprecipitation, lectin blot and quantitative real-time PCR were used to investigate the expression of N-acetyl-α-galactosaminyltransferases (GALNT8) and its role in regulating estrogen receptor α via bone morphogenetic protein signaling.
    [Biochimica Et Biophysica Acta-General Subjects]
    Abstract
    Microscopy images of pluripotent stem cells (PSCs) and PSC-derived cells for the #StemCellfie contest.
    PUBLICATIONSRanked by the impact factor of the journal

    Macrophage-Mediated RON Signaling Supports Breast Cancer Growth and Progression through Modulation of IL-35
    Researchers showed that the activation of the RON receptor tyrosine kinase signaling pathway specifically in macrophages supports breast cancer growth and metastasis.
    [Oncogene]
    Abstract

    Dual Cancer Stem Cell Manipulation to Enhance Phototherapy against Tumor Progression and Metastasis
    Investigators engineered a photodynamic nanoplatform to manipulate breast cancer stem cells against tumor progression and metastasis by not only remolding the disequilibrium state but also blocking the epithelial-mesenchymal transition process.
    [Journal of Controlled Release]
    AbstractGraphical Abstract

    Reg4 Interacts with CD44 to Regulate Proliferation and Stemness of Colorectal and Pancreatic Cancer Cells
    Researchers identified the cell surface binding partner of Reg4 and dissecting its role in colorectal cancer (CRC) and pancreatic cancer (PC) growth and stem cell survival. In vitro models of human CRC and PC were used to evaluate the results.
    [Molecular Cancer Research]
    Abstract

    Novel Cancer Stem Cell Marker MVP Enhances Temozolomide-Resistance in Glioblastoma
    Researchers found that sensitivity toTemozolomide (TMZ) was suppressed by significantly increasing the major vault protein (MVP) expression in glioblastoma multiforme cells with TMZ resistance.
    [Translational Oncology]
    Full Article

    Tumor Stemness and Immune Infiltration Synergistically Predict Response of Radiotherapy or Immunotherapy and Relapse in Lung Adenocarcinoma
    After integrating the tumor stemness index based on mRNA expression, immune score, mRNA expression, and clinical information from the TCGA database, scientists screened 380 tumor stemness and immune (TSI)-related genes and constructed a five TSI-specific-gene signature.
    [Cancer Medicine]
    Full Article

    Long Noncoding RNA AK023096 Interacts with hnRNP-K and Contributes to the Maintenance of Self-Renewal in Bladder Cancer Stem-Like Cells
    Scientists investigated the expression profile and biological function of lncRNAs in urothelial cancer stem-like cells by microarray analysis.
    [Experimental Cell Research]
    Full Article

    miR-126 in Extracellular Vesicles Derived from Hepatoblastoma Cells Promotes the Tumorigenesis of Hepatoblastoma through Inducing the Differentiation of BMSCs into Cancer Stem Cells
    Scientists explored the differentially expressed miRNAs related to tumor cell-derived extracellular vesciles (EVs) and the mechanism by which EVs regulated hepatoblastoma progression.
    [Journal of Immunology Research]
    Full Article

    Circulating Cancer Stem Cells Expressing EpCAM/CD90 in Hepatocellular Carcinoma: A Pilot Study for Predicting Tumor Recurrence after Living Donor Liver Transplantation
    Epithelial cell adhesion molecule+ (EpCAM+), cluster of differentiation 90+ (CD90+) and EpCAM+/CD90+ circulating tumor cells were sorted via fluorescence-activated cell sorting, and transcripts level of EpCAM, K19 and CD90 in the peripheral blood were analyzed via real-time polymerase chain reaction preoperatively.
    [Gut and Liver]
    Abstract
    Request your free copy of the 'Directed Differentiation of Pluripotent Stem Cells' Wallchart
    REVIEWS

    Noncanonical Roles of p53 in Cancer Stemness and Their Implications in Sarcomas
    The authors address the noncanonical roles of p53 and their implications in sarcoma initiation and progression.
    [Cancer Letters]
    Abstract

    Long Non-Coding RNAs Are Involved in Alternative Splicing and Promote Cancer Progression
    The authors review how long non-coding RNAs regulate alternative splicing and influence oncogenesis in different ways.
    [British Journal of Cancer]
    Full Article
    INDUSTRY AND POLICY NEWS

    BriaCell Adds Pioneering Immunologist and Cancer Immunotherapy Expert, Suzanne Ostrand-Rosenberg, PhD, to Its Scientific Advisory Board
    BriaCell Therapeutics Corp. announced the addition of Suzanne Ostrand-Rosenberg, PhD to its Scientific Advisory Board.
    [BriaCell Therapeutics Corp. (GlobeNewswire, Inc.)]
    Press Release
    FEATURED EVENT

    American College of Toxicology Annual Meeting
    November 10 – 19, 2021
    Virtual

    > See All Events
    JOB OPPORTUNITIES

    Scientist – Immune System-Tumor Interactions
    Oregon Health & Science University – Portland, Oregon, United States

    Senior Researcher – Cancer Progression and Metastasis
    St. Jude Children’s Research Hospital – Memphis, Tennessee, United States

    Postdoctoral Fellow – Ferroptosis and Metabolism in Cancer

    The University of Texas MD Anderson Cancer Center – Houston, Texas, United States

    Postdoctoral Scientist – Translational Cancer Biology and Therapeutics
    Cedars-Sinai Medical Center – Los Angeles, California, United States

    Postdoctoral Position – Pancreatic Adenocarcinoma

    University of California Los Angeles – Los Angeles, California, United States

    > See All Jobs

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