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Vol. 10.48 – 8 December, 2021
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Scientists showed that Cldn18 tumors accurately recapitulated advanced human gastric cancer in terms of disease morphology, aberrant gene expression, molecular markers and sites of distant metastases.
[Nature Cell Biology]
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PUBLICATIONSRanked by the impact factor of the journal
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A self-assembled heterodimer consisting of clustered regularly interspaced short palindromic repeats (CRISPR) /Cas12a linkage was designed for in situ identification and screening of gastric CSCs from gastric cancer cells. [Small]
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Scientists found that in the primary cultures of mouse fetal liver proerythroblasts (proEs), conditioned media prepared from glioma cells including patient-derived glioblastoma cells significantly facilitated the differentiation of proEs into erythroblasts.
[Genes to Cells]
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Researchers introduced a prodrug consisting of 1,3-oxathiolane as an ROS responsive scaffold, and an aldehyde protecting group of DEAB to deliver the co-treatment of anti-cancer drug and ALDH inhibitor upon reaction with ROS.
[Chemical Communications]
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Treatment effects on tumor-initiating cells were estimated by sphere-forming capacity in vitro, tumorigenicity in vivo, and flow cytometry.
[Hepatology Communications]
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Scientists established a new glioma stem-like cell, named U373-GSC, from the U373 glioma cell line. The cells exhibited stemness properties, e.g., expression of stem cell markers, self-renewal activity, multi-lineage differentiating abilities, and drug resistance.
[Experimental Cell Research]
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Researchers found that RNF168 expression was positively correlated with the overall survival, first-progression survival, and postprogression survival of lung adenocarcinoma, and did not correlate with these survivals of squamous cell carcinoma of lung.
[Environmental Toxicology]
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The authors investigated the function of miR-199 on gemcitabine-resistance in pancreatic cancer, as well as the underlying mechanism. [ACS Omega]
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Researchers found that secreted frizzled-related protein 2 (SFRP2) was downregulated in radiotherapy-treated glioma patients, and low SFRP2 expression was correlated with advanced tumor stage and poor prognosis.
[PLoS One]
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Scientists present a brief review exclusively commenting on the therapeutic approaches to eliminate glioblastoma stem cells and on the research publications about this topic of glioblastoma stem cells in relation to photodynamic therapy.
[Photodiagnosis and Photodynamic Therapy]
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City of Hope, announced it has entered into a definitive agreement to acquire Cancer Treatment Centers of America a network of oncology hospitals and outpatient care centers across the United States. [City of Hope (BioSpace, Inc.)]
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January 21 -23, 2022
Austin, Texas, United States
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Dana-Farber Cancer Institute – Boston, Massachusetts, United States
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The University of Chicago – Chicago, Illinois, United States
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Stanford University – Palo Alto, California, United States
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Fred Hutchinson Cancer Research Center – Seattle, Washington, United States
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