Cancer Stem Cell News Volume 10.48 | Dec 8 2021


    2021-12-08 | CSCN 10.48

    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 10.48 – 8 December, 2021

    A Tumor-Resident Lgr5+ Stem-Cell-Like Pool Drives the Establishment and Progression of Advanced Gastric Cancers

    Scientists showed that Cldn18 tumors accurately recapitulated advanced human gastric cancer in terms of disease morphology, aberrant gene expression, molecular markers and sites of distant metastases.
    [Nature Cell Biology]


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    CRISPR System-Linked Self-Assembling Nanoplatforms for Inspection and Screening of Gastric Cancer Stem Cells

    A self-assembled heterodimer consisting of clustered regularly interspaced short palindromic repeats (CRISPR) /Cas12a linkage was designed for in situ identification and screening of gastric CSCs from gastric cancer cells.


    Glioma Cells Remotely Promote Erythropoiesis as a Self-Expanding Strategy of Cancer Stem Cells

    Scientists found that in the primary cultures of mouse fetal liver proerythroblasts (proEs), conditioned media prepared from glioma cells including patient-derived glioblastoma cells significantly facilitated the differentiation of proEs into erythroblasts.
    [Genes to Cells]


    ROS Activated Prodrug for ALDH Overexpressed Cancer Stem Cells

    Researchers introduced a prodrug consisting of 1,3-oxathiolane as an ROS responsive scaffold, and an aldehyde protecting group of DEAB to deliver the co-treatment of anti-cancer drug and ALDH inhibitor upon reaction with ROS.
    [Chemical Communications]

    AbstractGraphical Abstract

    Acquired Resistance to Antiangiogenic Therapies in Hepatocellular Carcinoma Is Mediated by Yes-Associated Protein 1 Activation and Transient Expansion of Stem-Like Cancer Cells

    Treatment effects on tumor-initiating cells were estimated by sphere-forming capacity in vitro, tumorigenicity in vivo, and flow cytometry.
    [Hepatology Communications]


    Targeting alpha2,3-Sialylated Glycan in Glioma Stem-Like Cells by Maackia amurensis Lectin-II: A Promising Strategy for Glioma Treatment

    Scientists established a new glioma stem-like cell, named U373-GSC, from the U373 glioma cell line. The cells exhibited stemness properties, e.g., expression of stem cell markers, self-renewal activity, multi-lineage differentiating abilities, and drug resistance.
    [Experimental Cell Research]


    RNF168 Suppresses the Cancer Stem Cell-Like Traits of Nonsmall Cell Lung Cancer Cells by Mediating RhoC Ubiquitination

    Researchers found that RNF168 expression was positively correlated with the overall survival, first-progression survival, and postprogression survival of lung adenocarcinoma, and did not correlate with these survivals of squamous cell carcinoma of lung.
    [Environmental Toxicology]


    MiR-199 Reverses the Resistance to Gemcitabine in Pancreatic Cancer by Suppressing Stemness through Regulating the Epithelial–Mesenchymal Transition

    The authors investigated the function of miR-199 on gemcitabine-resistance in pancreatic cancer, as well as the underlying mechanism.
    [ACS Omega]

    Full ArticleGraphical Abstract

    Downregulation of SFRP2 Facilitates Cancer Stemness and Radioresistance of Glioma Cells via Activating Wnt/β-Catenin Signaling

    Researchers found that secreted frizzled-related protein 2 (SFRP2) was downregulated in radiotherapy-treated glioma patients, and low SFRP2 expression was correlated with advanced tumor stage and poor prognosis.
    [PLoS One]

    Full Article

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    Targeting Glioblastoma Stem Cells: The First Step of Photodynamic Therapy

    Scientists present a brief review exclusively commenting on the therapeutic approaches to eliminate glioblastoma stem cells and on the research publications about this topic of glioblastoma stem cells in relation to photodynamic therapy.
    [Photodiagnosis and Photodynamic Therapy]



    City of Hope® to Acquire Cancer Treatment Centers of America®, Bringing Leading-Edge Cancer Research, Discovery, Compassionate Care and Advanced Treatments to More Patients, Families and Communities Nationwide

    City of Hope, announced it has entered into a definitive agreement to acquire Cancer Treatment Centers of America a network of oncology hospitals and outpatient care centers across the United States.
    [City of Hope (BioSpace, Inc.)]

    Press Release


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