 | | Vol. 11.00 – 5 January, 2022 |
| |
|
|
| DLG5 was upregulated in malignant gliomas compared to other solid tumors, being the predominant DLG member in all glioblastoma molecular subtypes. DLG5 promoted glioblastoma stem cell invasion, viability, and self-renewal.
[Neuro-Oncology] |
|  |
|
|
| PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Scientists discovered an intrinsic signaling scaffold function of THEMIS2, which acted as a novel regulator of cancer stemness in promoting multiple cancer stemness properties including sphere formation, stemness markers expression, chemoresistance and tumorigenicity with low numbers of cancer cells implantation.
[Oncogene] |
|
|
|
| Investigators discovered a specificity protein 1-induced long noncoding RNA—DPPA2 upstream binding RNA (DUBR) and its high expression in hepatocellular carcinoma tissues and liver CSCs.
[Cancer Letters] |
|
|
|
| Scientists performed a series of experiments to verify whether HIF1α, HIF2α and Sox2 regulated glioma cell dedifferentiation under hypoxic conditions. Sphere formation by single glioma cells was observed, and CD133 and CD15 expression was compared between the normoxic and hypoxic groups.
[Journal of Cancer] |
|
|
|
| Investigators established chemo-resistant melanoma cells and found that expression of stemness genes were upregulated in the resistant melanoma cells. And Astragalus polysaccharide could downregulate expression of stemness genes.
[European Journal of Pharmacology] |
|
|
|
| A small molecule EHMT-2 inhibitor, BIX-01294, was evaluated for its activity in inhibiting CSCs in human colorectal cancer by in vitro and in vivo experiments.
[Biochemical and Biophysical Research Communications] |
|
|
|
| Scientists assessed adipogenic differentiation and its effect on the proliferation and stemness markers in CD44+ oral squamous cell carcinoma (OSCC) CSCs. D44+ CSCs were sorted by magnetic sorting from the single-cell suspension of the OSCC tumor.
[Medical Oncology] |
|
|
|
| Human papilloma virus (HPV)16 E6 silence or overexpression were carried out to evaluate the possible mechanisms of HPV16 E6 function in cervical cancer cells with different HPV16 E6 expression background.
[Cell Biology International] |
|
|
|
| Researchers verified that treatment with the STAT3 activator had significant reversal effects on the malignant behaviors of cervical cancer (CC) cells and CC stemness.
[Bioengineered] |
|  |
|
|
|
| The authors discuss cancer-type specific molecular targets, context-dependent mechanisms and future directions of research in targeting EHMT1/EHMT2 for the treatment of cancer.
[FEBS Journal] |
|
|
|
|
| Oncolyze, Inc, announced that the US FDA has granted the company orphan drug designation for its pipeline compound OM-301 for the treatment of acute myeloid leukemia. OM-301 is currently in pre-clinical development for AML and other cancers.
[Oncolyze, Inc. (GlobeNewswire, Inc.)] |
|
|
|
|
| February 5 – 9, 2022
Maui, Hawaii, United States |
|
|
|
|
|
| Baylor College of Medicine – Houston, Texas, United States |
|
|
|
| Francis Crick Institute – London, England United Kingdom |
|
|
|
| | Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
|
|
|
| | The University of Chicago – Chicago, Illinois, United States |
|
|
|
| Fred Hutchinson Cancer Research Center – Seattle, Washington, United States |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
