Cancer Stem Cell News Volume 11.05 | Feb 9 2022

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    2022-02-09 | CSCN 11.05


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 11.05 – 9 February, 2022
    TOP STORY

    Sox2 Induces Glioblastoma Cell Stemness and Tumor Propagation by Repressing TET2 and Deregulating 5hmC and 5mC DNA Modifications

    Researchers showed that ten–eleven translocation (TET) 2 loss associated with glioblastoma (GBM) stem cells and correlated with poor survival of GBM patients.
    [Signal Transduction and Targeted Therapy]

    Full Article


    Watch the webinar where Dr. Suzan Imren discusses factors affecting the balance between HSC self-renewal and leukemic transformation
    PUBLICATIONSRanked by the impact factor of the journal

    ADAR1-Mediated RNA Editing Links Ganglioside Catabolism to Glioblastoma Stem Cell Maintenance

    The authors interrogated the role of adenosine-to-inosine RNA editing mediated by adenosine deaminase acting on RNA (ADAR) 1 in glioblastoma stem cells (GSCs) and found that both ADAR1 and global RNA editomes were elevated in GSCs compared to normal neural stem cells.
    [Journal of Clinical Investigation]

    AbstractGraphical Abstract

    DOT1L Is a Novel Cancer Stem Cell Target for Triple Negative Breast Cancer

    Scientists tested if inhibition of DOT1L, an epigenetic regulator of normal tissue stem/progenitor populations, would target triple negative breast cancers stem cells.
    [Clinical Cancer Research]

    AbstractFull Article

    Identification of Vascular Cues Contributing to Cancer Cell Stemness and Function

    Researchers dissected vascular cues influencing glioblastoma stem cell (GSC) gene expression and function to perfusion-based vascular cues, as well as to those requiring direct GSC-endothelial cell contacts.
    [Angiogenesis]

    Abstract

    Chaperone-Mediated Autophagy Controls Proteomic and Transcriptomic Pathways to Maintain Glioma Stem Cell Activity

    Investigators showed that LAMP2A expression was enriched in patient-derived glioblastoma stem cells (GSC), and its depletion diminished GSC-mediated tumorigenic activities.
    [Cancer Research]

    AbstractFull Article

    Chloride Intracellular Channel 1 Activity Is Not Required for Glioblastoma Development but Its Inhibition Dictates Glioma Stem Cell Responsivity to Novel Biguanide Derivatives

    Scientists synthesized a small library of novel biguanide-based compounds that were tested as antiproliferative agents for glioblastoma stem cells derived from human glioblastomas, in vitro using 2D and 3D cultures and in vivo in the zebrafish model.
    [Journal of Experimental & Clinical Cancer Research]

    Full Article

    Somatic Mutation Analyses of Stem-Like Cells in Gingivobuccal Oral Squamous Cell Carcinoma Reveals DNA Damage Response Genes

    To understand the role of CSCs in the disease scientists performed transcriptomics analysis on RNA-seq data from gingivobuccal oral squamous cell carcinoma primary tumors.
    [Genomics]

    Abstract
    Full Article

    TGF-β1 Induced Deficiency of linc00261 Promotes Epithelial–Mesenchymal-Transition and Stemness of Hepatocellular Carcinoma via Modulating SMAD3

    Researchers showed that linc00261 was down-regulated in TGF-β1 stimulated cells, and forced expression of linc00261 attenuated epithelial–mesenchymal transition and stem-like traits in hepatocellular carcinoma.
    [Journal of Translational Medicine]

    Full Article

    Secretory Phospholipase sPLA2-IIAloss Impairs Tumorigenic and Metastatic Potential in Breast Cancer Cells

    Scientists observed an increased level of EMT markers in CSC population. Overexpression of secretory phospholipase sPLA2-IIA was found in CSCs.
    [Biochemical and Biophysical Research Communications]

    AbstractGraphical Abstract

    Kaempferol and Apigenin Suppresses the Stemness Properties of TNBC Cells by Modulating Sirtuins

    Researchers observed kaempferol and apigenin inhibited cellular proliferation by DNA damage and S-phase cell cycle arrest in TNBC Cells.
    [Molecular Diversity]

    AbstractGraphical Abstract

    Scientific resources to support your hematopoiesis research. Learn More!
    REVIEWS

    Mechanisms Regulating PD-L1 Expression in Cancers and Associated Opportunities for Novel Small-Molecule Therapeutics

    The authors describe the roles of the diverse post-translational modifications of PD-L1, including phosphorylation, palmitoylation, glycosylation, acetylation and ubiquitination.
    [Nature Reviews Clinical Oncology]

    Abstract

    Emerging New Therapeutic Antibody Derivatives for Cancer Treatment

    Scientists discuss the rationale and mechanism of action of various antibody formats, including antibody–drug conjugates, antibody–oligonucleotide conjugates, bispecific/multispecific antibodies, immunocytokines, antibody fragments, and scaffold proteins.
    [Signal Transduction and Targeted Therapy]

    Abstract

    INDUSTRY AND POLICY NEWS

    enGene Announces Positive Preliminary Phase I/II Data with EG-70 in BCG-Unresponsive Non-Muscle Invasive Bladder Cancer

    enGene, Inc. announced positive results from its LEGEND study, a first-in-human Phase I/II clinical trial of EG-70 for the treatment of high-grade non-muscle Invasive bladder cancer in patients with carcinoma in situ that are BCG-unresponsive.
    [enGene, Inc. (Newswire, Inc.)]

    Press Release

    FEATURED EVENT

    ISCT ANZ – BAA Joint Scientific Meeting

    February 24 – February 25, 2022
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Research Scientist – Immunology

    Babraham Institute – Babraham, Cambridgeshire, United Kingdom

    Postdoctoral Fellow – Cancer Immune Biomarkers

    Albert Einstein College of Medicine – Bronx, New York, United States

    Postdoctoral Fellow – Lung Carcinogenesis

    Albert Einstein College of Medicine – Bronx, New York, United States

    Postdoctoral Scholar – Tumor Immunology

    Moffit Cancer Center – Tampa Bay, Florida, United States

    PhD Student – Chronic Lymphocytic Leukemia

    Luxembourg Institute of Health – Luxembourg, Luxembourg

    > See All Jobs

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