 | | Vol. 11.05 – 9 February, 2022 |
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| Researchers showed that ten–eleven translocation (TET) 2 loss associated with glioblastoma (GBM) stem cells and correlated with poor survival of GBM patients.
[Signal Transduction and Targeted Therapy] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors interrogated the role of adenosine-to-inosine RNA editing mediated by adenosine deaminase acting on RNA (ADAR) 1 in glioblastoma stem cells (GSCs) and found that both ADAR1 and global RNA editomes were elevated in GSCs compared to normal neural stem cells.
[Journal of Clinical Investigation] |
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| Scientists tested if inhibition of DOT1L, an epigenetic regulator of normal tissue stem/progenitor populations, would target triple negative breast cancers stem cells.
[Clinical Cancer Research] |
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| Researchers dissected vascular cues influencing glioblastoma stem cell (GSC) gene expression and function to perfusion-based vascular cues, as well as to those requiring direct GSC-endothelial cell contacts.
[Angiogenesis] |
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| Investigators showed that LAMP2A expression was enriched in patient-derived glioblastoma stem cells (GSC), and its depletion diminished GSC-mediated tumorigenic activities.
[Cancer Research] |
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| Scientists synthesized a small library of novel biguanide-based compounds that were tested as antiproliferative agents for glioblastoma stem cells derived from human glioblastomas, in vitro using 2D and 3D cultures and in vivo in the zebrafish model.
[Journal of Experimental & Clinical Cancer Research] |
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| To understand the role of CSCs in the disease scientists performed transcriptomics analysis on RNA-seq data from gingivobuccal oral squamous cell carcinoma primary tumors.
[Genomics] |
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| Researchers showed that linc00261 was down-regulated in TGF-β1 stimulated cells, and forced expression of linc00261 attenuated epithelial–mesenchymal transition and stem-like traits in hepatocellular carcinoma.
[Journal of Translational Medicine] |
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| Scientists observed an increased level of EMT markers in CSC population. Overexpression of secretory phospholipase sPLA2-IIA was found in CSCs.
[Biochemical and Biophysical Research Communications] |
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| Researchers observed kaempferol and apigenin inhibited cellular proliferation by DNA damage and S-phase cell cycle arrest in TNBC Cells.
[Molecular Diversity] |
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| The authors describe the roles of the diverse post-translational modifications of PD-L1, including phosphorylation, palmitoylation, glycosylation, acetylation and ubiquitination.
[Nature Reviews Clinical Oncology] |
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| Scientists discuss the rationale and mechanism of action of various antibody formats, including antibody–drug conjugates, antibody–oligonucleotide conjugates, bispecific/multispecific antibodies, immunocytokines, antibody fragments, and scaffold proteins.
[Signal Transduction and Targeted Therapy] |
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| enGene, Inc. announced positive results from its LEGEND study, a first-in-human Phase I/II clinical trial of EG-70 for the treatment of high-grade non-muscle Invasive bladder cancer in patients with carcinoma in situ that are BCG-unresponsive.
[enGene, Inc. (Newswire, Inc.)] |
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| February 24 – February 25, 2022
Virtual |
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| Babraham Institute – Babraham, Cambridgeshire, United Kingdom |
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| | Albert Einstein College of Medicine – Bronx, New York, United States |
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| | Albert Einstein College of Medicine – Bronx, New York, United States |
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| | Moffit Cancer Center – Tampa Bay, Florida, United States |
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| | Luxembourg Institute of Health – Luxembourg, Luxembourg |
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