 | | Vol. 11.05 – 9 February, 2022 |
| |
|
|
| Researchers showed that ten–eleven translocation (TET) 2 loss associated with glioblastoma (GBM) stem cells and correlated with poor survival of GBM patients.
[Signal Transduction and Targeted Therapy] |
|
 |
|
|
| PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| The authors interrogated the role of adenosine-to-inosine RNA editing mediated by adenosine deaminase acting on RNA (ADAR) 1 in glioblastoma stem cells (GSCs) and found that both ADAR1 and global RNA editomes were elevated in GSCs compared to normal neural stem cells.
[Journal of Clinical Investigation] |
|
|
|
| Scientists tested if inhibition of DOT1L, an epigenetic regulator of normal tissue stem/progenitor populations, would target triple negative breast cancers stem cells.
[Clinical Cancer Research] |
|
|
|
| Researchers dissected vascular cues influencing glioblastoma stem cell (GSC) gene expression and function to perfusion-based vascular cues, as well as to those requiring direct GSC-endothelial cell contacts.
[Angiogenesis] |
|
|
|
| Investigators showed that LAMP2A expression was enriched in patient-derived glioblastoma stem cells (GSC), and its depletion diminished GSC-mediated tumorigenic activities.
[Cancer Research] |
|
|
|
| Scientists synthesized a small library of novel biguanide-based compounds that were tested as antiproliferative agents for glioblastoma stem cells derived from human glioblastomas, in vitro using 2D and 3D cultures and in vivo in the zebrafish model.
[Journal of Experimental & Clinical Cancer Research] |
|
|
|
| To understand the role of CSCs in the disease scientists performed transcriptomics analysis on RNA-seq data from gingivobuccal oral squamous cell carcinoma primary tumors.
[Genomics] |
|
|
|
| Researchers showed that linc00261 was down-regulated in TGF-β1 stimulated cells, and forced expression of linc00261 attenuated epithelial–mesenchymal transition and stem-like traits in hepatocellular carcinoma.
[Journal of Translational Medicine] |
|
|
|
| Scientists observed an increased level of EMT markers in CSC population. Overexpression of secretory phospholipase sPLA2-IIA was found in CSCs.
[Biochemical and Biophysical Research Communications] |
|
|
|
| Researchers observed kaempferol and apigenin inhibited cellular proliferation by DNA damage and S-phase cell cycle arrest in TNBC Cells.
[Molecular Diversity] |
|
|
|
|
| The authors describe the roles of the diverse post-translational modifications of PD-L1, including phosphorylation, palmitoylation, glycosylation, acetylation and ubiquitination.
[Nature Reviews Clinical Oncology] |
|
|
|
| Scientists discuss the rationale and mechanism of action of various antibody formats, including antibody–drug conjugates, antibody–oligonucleotide conjugates, bispecific/multispecific antibodies, immunocytokines, antibody fragments, and scaffold proteins.
[Signal Transduction and Targeted Therapy] |
|
|
|
|
| enGene, Inc. announced positive results from its LEGEND study, a first-in-human Phase I/II clinical trial of EG-70 for the treatment of high-grade non-muscle Invasive bladder cancer in patients with carcinoma in situ that are BCG-unresponsive.
[enGene, Inc. (Newswire, Inc.)] |
|
|
|
|
| February 24 – February 25, 2022
Virtual |
|
|
|
|
|
| Babraham Institute – Babraham, Cambridgeshire, United Kingdom |
|
|
|
| | Albert Einstein College of Medicine – Bronx, New York, United States |
|
|
|
| | Albert Einstein College of Medicine – Bronx, New York, United States |
|
|
|
| | Moffit Cancer Center – Tampa Bay, Florida, United States |
|
|
|
| | Luxembourg Institute of Health – Luxembourg, Luxembourg |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
