Cancer Stem Cell News Volume 11.08 | March 2 2022

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    2022-03-02 | CSCN 11.08


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 11.08 – 2 March, 2022
    TOP STORY

    VCAM1 Confers Innate Immune Tolerance on Haematopoietic and Leukaemic Stem Cells

    Scientists showed that VCAM1 was expressed on healthy haematopoietic stem cells and upregulated on leukaemic stem cells, where it served as a quality-control checkpoint for entry into bone marrow by providing ‘don’t-eat-me’ stamping in the context of major histocompatibility complex class-I presentation.
    [Nature Cell Biology]

    Abstract

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    3D Bioprinted GelMA-Nanoclay Hydrogels Induce Colorectal Cancer Stem Cells through Activating Wnt/β-Catenin Signaling

    The authors found that gelatin methacryloyl (GelMA)-nanoclay hybrid hydrogels could induce and enrich colorectal CSCs assisted by three-dimensional bioprinting.
    [Small]

    Full Article

    Targeting ULK1 in Cancer Stem Cells: Insight from Chronic Myeloid Leukemia

    Pharmacological inhibition of ULK1 resulted in stress-induced differentiation of leukemic stem cells (LSCs), rendering them sensitive to tyrosine kinase inhibitor treatment, uncovering a promising strategy for selective eradication of LSCs in chronic myeloid leukemia patients.
    [Autophagy]

    Abstract

    Effective Targeting of Breast Cancer Stem Cells by Combined Inhibition of Sam68 and Rad51

    Using breast cancer sphere cells (BCSphCs) as a model, researchers showed that breast cancer stem-like cells express high levels of Myc, which required the presence of the multifunctional DNA/RNA binding protein Sam68 for the DNA-damage repair.
    [Oncogene]

    Full Article

    HOXA5 Is Amplified in Glioblastoma Stem Cells and Promotes Tumor Progression by Transcriptionally Activating PTPRZ1

    Scientists identified the gene amplification and protein overexpression of HOXA5 in glioma stem cells (GSCs) and its function in regulating GSC maintenance and the downstream transcriptional effector.
    [Cancer Letters]

    Abstract

    NOX4 Regulates TGFβ-Induced Proliferation and Self-Renewal in Glioblastoma Stem Cells

    A glioblastoma tumoral mass was characterized by a small cellular subpopulation, glioblastoma stem cells that has been held responsible for glioblastoma initiation, cell invasion, proliferation, relapse and resistance to chemo and radiotherapy.
    [Molecular Oncology]

    Abstract

    siRNA-Induced CD44 Knockdown Suppresses the Proliferation and Invasion of Colorectal Cancer Stem Cells through Inhibiting Epithelial–Mesenchymal Transition

    To examine the contribution of siRNA-induced knockdown of CD44 to the biological features of colorectal CSCs, colorectal CSCs HCT116-CSCs were generated, and CD44 was knocked down in HCT116-CSCs using siRNA.
    [Journal of Cellular and Molecular Medicine]

    Abstract

    Chronic Hexavalent Chromium Exposure Up-Regulates the RNA Methyltransferase METTL3 Expression to Promote Cell Transformation, Cancer Stem Cell-Like Property and Tumorigenesis

    Researchers investigated the mechanism of hexavalent chromium carcinogenesis focusing on the role of the epitranscriptomic dysregulation.
    [Toxicological Sciences]

    Abstract

    LINC01234 Regulates MicroRNA-27b-5p to Induce the Migration, Invasion and Self-Renewal of Ovarian Cancer Stem Cells through Targeting SIRT5

    Scientists investigated the effect of LINC01234 on the differentiation and self-renewal of ovarian cancer stem cells through adsorption of microRNA-27b-5p to target sirtuins 5 (SIRT5).
    [Cell Cycle]

    Full Article

    Cancer Stem Cell Markers CD44v9+/CD133– Are Associated with Low Apoptosis in Both Sporadic and Ulcerative Colitis-Associated Colorectal Cancers

    To elucidate tumor cell behavior associated with CSC marker expression, the expression of CD133, CD44v9, and ALDH1A1, which are considered markers of CSCs, was examined in sporadic and ulcerative colitis-associated colorectal tumors.
    [Histology and Histopathology]

    Abstract

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    Glioblastoma Microenvironment: The Stromal Interactions

    Investigators draw an interaction map for glioblastomas (GBMs) and promote awareness of the complexity of the GBM microenvironment.
    [Pathology Research and Practice]

    AbstractGraphical Abstract

    INDUSTRY AND POLICY NEWS

    Akeso Announced Collaboration with Chipscreen Biosciences to Initiated a Clinical Trial of PD-1/CTLA-4 Bi-Specific Antibody in Combination with Chiauranib for PD-(L)1 Pretreated ES-SCLC

    Akeso, Inc. announced that it entered into a collaboration agreement with Shenzhen Chipscreen Biosciences Co., Ltd. to establish a clinical trial partnership to jointly conduct a Phase Ib/II clinical trial of PD-1/CTLA-4 bi-specific antibody Cadonilimab in combination with Chiauranib for the treatment of first-line platinum-based chemotherapy in combination with PD-(L)1 inhibitor treatment regimen for extensive-stage small-cell lung cancer.
    [Akeso, Inc. (BioSpace, Inc.)]

    Press Release

    RenovoRx Enrolls First Pancreatic Cancer Patient at Columbia University’s New York-Presbyterian Hospital Irving Medical Center in Ongoing TIGeR-PaC Phase III Clinical Trial

    RenovoRx, Inc. announced enrollment of its first patient at one of its newest clinical sites, Columbia University, in its ongoing TIGeR-PaC Phase II clinical trial to evaluate the company’s therapy platform RenovoTAMP™ as a potential treatment option for locally advanced pancreatic cancer.
    [RenovoRx, Inc.]

    Press Release

    FEATURED EVENT

    EMBO: Stroke-Immunology

    March 9 – 12, 2022
    Munich, Germany

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    JOB OPPORTUNITIES

    PhD Scientist – Oncology

    University of Virginia School of Medicine – Charlottesville, Virginia, United States

    Postdoctoral Associate – Liver Cancer

    Baylor College of Medicine – Houston, Texas, United States

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    BC Cancer Research Institute – BC Cancer Research Institute

    Postdoctoral Associate – Immunology and Nanomedicine

    Florida International University – Miami, Florida, United States

    Postdoctoral Scholar – Tumor Immunology

    Moffit Cancer Center – Tampa Bay, Florida, United States

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