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Vol. 11.08 – 2 March, 2022
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Scientists showed that VCAM1 was expressed on healthy haematopoietic stem cells and upregulated on leukaemic stem cells, where it served as a quality-control checkpoint for entry into bone marrow by providing ‘don’t-eat-me’ stamping in the context of major histocompatibility complex class-I presentation.
[Nature Cell Biology]
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PUBLICATIONSRanked by the impact factor of the journal
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The authors found that gelatin methacryloyl (GelMA)-nanoclay hybrid hydrogels could induce and enrich colorectal CSCs assisted by three-dimensional bioprinting.
[Small]
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Pharmacological inhibition of ULK1 resulted in stress-induced differentiation of leukemic stem cells (LSCs), rendering them sensitive to tyrosine kinase inhibitor treatment, uncovering a promising strategy for selective eradication of LSCs in chronic myeloid leukemia patients.
[Autophagy]
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Using breast cancer sphere cells (BCSphCs) as a model, researchers showed that breast cancer stem-like cells express high levels of Myc, which required the presence of the multifunctional DNA/RNA binding protein Sam68 for the DNA-damage repair. [Oncogene]
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Scientists identified the gene amplification and protein overexpression of HOXA5 in glioma stem cells (GSCs) and its function in regulating GSC maintenance and the downstream transcriptional effector.
[Cancer Letters]
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A glioblastoma tumoral mass was characterized by a small cellular subpopulation, glioblastoma stem cells that has been held responsible for glioblastoma initiation, cell invasion, proliferation, relapse and resistance to chemo and radiotherapy.
[Molecular Oncology]
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To examine the contribution of siRNA-induced knockdown of CD44 to the biological features of colorectal CSCs, colorectal CSCs HCT116-CSCs were generated, and CD44 was knocked down in HCT116-CSCs using siRNA.
[Journal of Cellular and Molecular Medicine]
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Researchers investigated the mechanism of hexavalent chromium carcinogenesis focusing on the role of the epitranscriptomic dysregulation.
[Toxicological Sciences]
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Scientists investigated the effect of LINC01234 on the differentiation and self-renewal of ovarian cancer stem cells through adsorption of microRNA-27b-5p to target sirtuins 5 (SIRT5).
[Cell Cycle]
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To elucidate tumor cell behavior associated with CSC marker expression, the expression of CD133, CD44v9, and ALDH1A1, which are considered markers of CSCs, was examined in sporadic and ulcerative colitis-associated colorectal tumors.
[Histology and Histopathology]
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Investigators draw an interaction map for glioblastomas (GBMs) and promote awareness of the complexity of the GBM microenvironment.
[Pathology Research and Practice]
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Akeso, Inc. announced that it entered into a collaboration agreement with Shenzhen Chipscreen Biosciences Co., Ltd. to establish a clinical trial partnership to jointly conduct a Phase Ib/II clinical trial of PD-1/CTLA-4 bi-specific antibody Cadonilimab in combination with Chiauranib for the treatment of first-line platinum-based chemotherapy in combination with PD-(L)1 inhibitor treatment regimen for extensive-stage small-cell lung cancer. [Akeso, Inc. (BioSpace, Inc.)]
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RenovoRx, Inc. announced enrollment of its first patient at one of its newest clinical sites, Columbia University, in its ongoing TIGeR-PaC Phase II clinical trial to evaluate the company’s therapy platform RenovoTAMP™ as a potential treatment option for locally advanced pancreatic cancer. [RenovoRx, Inc.]
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March 9 – 12, 2022
Munich, Germany
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University of Virginia School of Medicine – Charlottesville, Virginia, United States
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Baylor College of Medicine – Houston, Texas, United States
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BC Cancer Research Institute – BC Cancer Research Institute
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Florida International University – Miami, Florida, United States
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Moffit Cancer Center – Tampa Bay, Florida, United States
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