Cancer Stem Cell News Volume 11.15 | Apr 20 2022

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    2022-04-20 | CSCN 11.15


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 11.15 – 20 April, 2022
    TOP STORY

    Immunoglobulin Superfamily Member 8 Maintains Myeloid Leukemia Stem Cells through Inhibition of β-Catenin Degradation

    Scientists investigated the role of immunoglobulin superfamily member 8 on normal and malignant hematopoietic stem cells, mainly using the conditional knockout model.
    [Leukemia]

    Abstract
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    PUBLICATIONSRanked by the impact factor of the journal

    Reactive Oxygen Species-Inducing Titanium Peroxide Nanoparticles as Promising Radiosensitizers for Eliminating Pancreatic Cancer Stem Cells

    CSCs were isolated from MIA PaCa-2 and PANC1 human pancreatic cancer cell lines. Titanium peroxide nanoparticles were synthesized from titanium dioxide nanoparticles and utilized as radiosensitizers.
    [Journal of Experimental & Clinical Cancer Research]

    Full Article

    MEOX2-Mediated Regulation of Cathepsin S Promotes Cell Proliferation and Motility in Glioma

    Investigators reported that MEOX2 functioned as a tumor-initiating element in glioma. Bioinformatic analysis of public databases and investigation of MEOX2 expression in patients with glioma demonstrated that MEOX2 was abundant at both mRNA and protein levels in glioma.
    [Cell Death & Disease]

    Full Article

    Circulating Tumor DNA and Its Clinical Utility in Predicting Treatment Response or Survival in Patients with Metastatic Colorectal Cancer: A Systematic Review and Meta-Analysis

    The authors investigated the current knowledge on circulating tumor DNA and its clinical utility in predicting outcomes in patients with metastatic colorectal cancer.
    [British Journal of Cancer]

    Abstract

    Liver Tumor-Initiating Cells Initiate the Formation of a Stiff Cancer Stem Cell Microenvironment Niche by Secreting LOX

    Investigators reported that the voltage-gated calcium channel α2δ1 subunit-positive tumor-initiating cells of hepatocellular carcinoma specifically secreted LOX, which led to the crosslinking of collagen, forming a stiff extracellular matrix.
    [Carcinogenesis]

    Abstract

    Overexpression of FOXD2-AS1 Enhances Proliferation and Impairs Differentiation of Glioma Stem Cells by Activating the NOTCH Pathway via TAF-1

    Colony formation assay, sphere formation assay, and flow cytometry were used to evaluate glioma stem cell stemness.
    [Journal of Cellular and Molecular Medicine]

    Full Article

    Development of a Portable Hypoxia Chamber for Ultra-High Dose Rate Laser-Driven Proton Radiobiology Applications

    Researchers measured the oxygen enhancement ratio for cell survival after X-ray exposure in normal fibroblast and radioresistant patient-derived glioblastoma stem cells.
    [Radiation Oncology]

    Full Article

    lncRNA KCNQ1OT1 Promotes EMT, Angiogenesis, and Stemness of Pituitary Adenoma by Upregulation of RAB11A

    Scientists investigated the effect and mechanism of long noncoding RNA KCNQ1OT1 on pituitary adenoma. The KCNQ1OT1 expression in invasive and noninvasive PA tissues was detected by real-time fluorescence quantitative polymerase chain reaction.
    [Journal of Oncology]

    Full Article

    The Gut Microbial Metabolite Formate Exacerbates Colorectal Cancer Progression

    Researchers showed that formate, a metabolite produced by colorectal cancer (CRC)-associated bacterium Fusobacterium nucleatum, promoted CRC development and that microbiome-derived formate drove CRC tumor invasion by triggering AhR signalling, while increasing cancer stemness.
    [Nature Metabolism]

    Full Article
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    REVIEWS

    Engineered Cellular Immunotherapies in Cancer and Beyond

    Scientists outlined how developments in the cancer field are paving the way for cellular immunotherapeutics in other diseases.
    [Nature Medicine]

    Abstract

    HDACs and the Epigenetic Plasticity of Cancer Cells: Target the Complexity

    The authors discuss recent advances in understanding the contribution of HDACs to the maintenance of the transformed state and the rational for their selective targeting.
    [Pharmacology & Therapeutics]

    Full Article
    INDUSTRY AND POLICY NEWS

    Memorial Sloan Kettering Cancer Center Announces The Starr Foundation Program for Discovery Science

    Memorial Sloan Kettering Cancer Center announced the establishment of The Starr Foundation Program for Discovery Science, a pioneering new initiative made possible by a $50 million gift from The Starr Foundation.
    [Memorial Sloan Kettering Cancer Center (News Wise)]

    Press Release
    FEATURED EVENT

    ISCT 2022 San Francisco Annual Meeting

    May 4 – 7, 2022
    San Francisco, California, United States

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    JOB OPPORTUNITIES

    Associate Professor – Cancer Immunology

    McGill University – Montreal, Quebec, Canada

    Scientific Director – Cancer Research

    Cyprus Cancer Research Institute – Nicosia, Cyprus

    Tenure-Track Associate Professor – Stem Cell Biology

    The University of Hong Kong – Hong Kong, China

    Postdoctoral Position – Tumor Heterogeneity

    Luxembourg Institute of Health – Strassen, Luxembourg

    Principal Scientific Researcher – Cell and Tissue Genomics

    Genentech, Inc. – South San Francisco, California, United States

    > See All Jobs

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