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Investigators revealed a robust link between cancer stemness and immunotherapy resistance and developed a promising signature, Stem.Sig, which showed increased performance in comparison to other signatures regarding immune checkpoint inhibitor response prediction.
[Genome Medicine]
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PUBLICATIONSRanked by the impact factor of the journal
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Scientists uncovered a crucial role of Galectin-1 (Gal-1) in carcinoma-associated fibroblasts that orchestrated an inflammatory CSC niche supporting hepatocellular carcinoma (HCC) progression and demonstrated that targeting Gal-1 could be a potential therapy for fibrosis-related HCC.
[Oncogene]
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AC133+ cancer stem cells and PD-L1+CD73+ myeloid cells were detectable in primary human small cell lung cancer tissues, suggesting that patients may benefit from the triple-immunotherapy.
[Cancer Letters]
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Circulating tumor cells were chosen as template biomarkers to verify the application of BGC-SW modified with sgc8-aptamer in various separation processes of untreated biofluids.
[Analytical Chemistry]
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Investigators found that loss of TAR DNA-binding protein-43 (TDP43) inhibited breast CSC stemness by reducing the abundance of cluster of differentiation 44 (CD44) variant alternative splicing isoforms.
[Cell Death & Disease]
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New protocols for monocyte-derived dendritic cell (mMo-DC) production using automatization and circulating tumor cell lysates were introduced including a feasible in vitro assay for mMo-DC efficacy evaluation.
[Cancer Immunology Immunotherapy]
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Circulating tumor cells were enriched from blood samples of hepatocellular carcinoma patients and cultured by 3D system.
[Liver International]
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Preliminary testing of circulating tumor cells isolated from patients with non-small cell lung cancer demonstrated heterogeneity in PD-L1 and HLA I expression and promising clinical value in predicting PFS.
[Biomarker Research]
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Researchers suggested that miR-600 promotes ovarian cancer cell stemness, proliferation and metastasis via directly downregulating kruppel like factor 9 (KLF9), and impairing miR-600 levels may be a new treatment strategy for ovarian cancer in the future.
[Journal of Ovarian Research]
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The authors discuss in detail the importance of feed-forward loops of cancer cells with their microenvironment including the secretome, interaction with specialized tissue-specific cells, nutrients/metabolites, and that novel therapies should target not only the cancer cells but also the tumor microenvironment.
[EMBO Molecular Medicine]
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P38 mitogen-activated protein kinase (p38 MAPK) was downstream of several CSC-specific signaling pathways, and it played an important role in CSC development and maintenance and contributed to metastasis and chemoresistance.
[Oncogene]
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Scientists investigate the multidisciplinary data from recent large epidemiological chemoprevention studies for long-term use of oral contraceptives to reduce cancer risk and differences in cellular and molecular processes between embryonic implantation to endometrium and adhesion/invasion of circulating tumor cells to vascular endothelium.
[European Journal of Medicinal Chemistry]
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The New York University (NYU) community was plunged into turmoil this week by the news that its Grossman School of Medicine is considering hiring prominent biologist David Sabatini, who had been forced out of jobs at the Whitehead Institute for Biomedical Research and the Massachusetts Institute of Technology for sexual misconduct.
[New York University (Science)]
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Harpoon Therapeutics, Inc. announced that it has entered into a clinical supply agreement with Roche to supply atezolizumab for use in the Company’s HPN328, a DLL3 targeting TriTAC®, clinical development program.
[Harpoon Therapeutics, Inc.]
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June 15 – 18, 2022
San Francisco, California, United States
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Institute of Cancer Research – London, United Kingdom
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Johns Hopkins University – Baltimore, Maryland, United States
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McGill University – Montreal, Quebec, Canada
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Cyprus Cancer Research Institute – Nicosia, Cyprus
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The University of Hong Kong – Hong Kong, China
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