Cancer Stem Cell News Volume 11.19 | May 18 2022


    2022-05-18 | CSCN 11.29

    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 11.19 – 18 May, 2022

    Stromal Notch Ligands Foster Lymphopenia-Driven Functional Plasticity and Homeostatic Proliferation of Naïve B Cells

    In lymphopenic spleens, transferred B cells gradually lost their follicular phenotype and acquired characteristics of marginal zone B cells, as judged by cell surface phenotype, expression of integrins and chemokine receptors, and positioning close to the marginal sinus.
    [Journal of Clinical Investigation]

    AbstractGraphical AbstractFull Article
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    Locally Secreted BiTEs Complement CAR T Cells by Enhancing Killing of Antigen Heterogeneous Solid Tumors

    Scientists detected the expression of tumor-associated epidermal growth factor receptor (EGFR), EGFR variant III, and interleukin-13 receptor alpha 2 on glioma tissues and CSCs.
    [Molecular Therapy]

    AbstractGraphical Abstract

    LGR4 Cooperates with PrPc to Endow the Stemness of Colorectal Cancer Stem Cells Contributing to Tumorigenesis and Liver Metastasis

    Researchers reported that a leucine-rich repeat containing G protein-coupled receptor 4 (LGR4) cooperated with CD44 and PrPc; the latter contributed significantly to metastatic capacity and defined the stemness characteristics of colorectal CSCs.
    [Cancer Letters]


    Rationally Screened and Designed ABCG2-Binding Aptamers for Targeting Cancer Stem Cells and Reversing Multidrug Resistance

    ATP-binding cassette, subfamily G, isoform 2 protein (ABCG2) glycosylated extracellular region-binding aptamers were efficiently screened by a cladded molecularly imprinted polymer-based in vitro screening method and further rationally engineered into cyclic bivalent aptamers.
    [Analytical Chemistry]

    AbstractGraphical Abstract

    PLGA-Nano-Encapsulated Disulfiram Inhibits Hypoxia-Induced NFκB, Cancer Stem Cells and Targets Glioblastoma in Vitro and in Vivo

    The in vitro anti-glioblastoma (GBM) stem cell activity of disulfiram (DS) and in vivo anti-GBM efficacy of poly lactic-co-glycolic acid nanoparticle-encapsulated DS were examined.
    [Molecular Cancer Therapeutics]


    TFEB and TFE3 Depletion Increases Cancer Stem Cell Characteristics and EMT in Triple-Negative Breast Cancer

    Scientists showed that knockout of TFEB and combined knockout of TFEB and TFE3 resulted in an increase in stem cell character and epithelial-mesenchymal transition, which could correlate to increased tumor metastasis and poorer prognosis.
    [FASEB Journal]


    Optimization of Production and Characterization of a Recombinant Soluble Human Cripto-1 Protein Inhibiting Self-Renewal of Cancer Stem Cells

    The authors optimized the protocol for a T7 expression system, purification from inclusion bodies under denatured conditions refolding of a His-tagged Cripto-1 protein.
    [Journal of Cellular Biochemistry]


    Cytotoxic Effect of Disulfiram/Copper on Human Cervical Cancer Cell Lines and LGR5-Positive Cancer Stem-Like Cells

    Scientists reported that high aldehyde dehydrogenase activity represented a functional marker for cervical CSCs.
    [BMC Cancer]

    Full Article

    ISG15 Enhances Glioma Cell Stemness by Promoting Oct4 Protein Stability

    Loss of functional experiments indicated that ISG15 positively regulated glioma cell stemness, as evident by the increase of sphere formation ability, ALDH activity, stemness marker expression, and tumor-initiating ability.
    [Environmental Toxicology]


    ARL2 Is Required for Homologous Recombination Repair and Colon Cancer Stem Cell Survival

    ARL2 expression was positively associated with the expression of all six RAD51 family genes, which were essential for homologous recombination repair.
    [Febs Open Bio]


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    Lung Cancer Stem Cells and Their Clinical Implications

    Mouse models of lung cancer have shown that lung CSCs reside in niches that are essential for the maintenance of stemness, plasticity, enable antitumor immune evasion, and provide metastatic potential.
    [Cold Spring Harbor Perspectives in Medicine]


    The Role of Cancer Stem Cell-Derived Exosomes in Cancer Progression

    Studies have shown that CSC-derived exosomes carry a variety of gene mutations and specific epigenetic modifications indicative of unique cell phenotypes and metabolic pathways, enabling exchange of information in the tumor microenvironment to promote tumor invasion and metastasis.
    [Stem Cell International]

    Full Article

    Sorrento Announces FDA Authorization to Proceed With Phase II Study of Abivertinib (Fujovee™) to Treat Metastatic Castrate Resistant Prostate Cancer (MAVERICK Trial)

    Sorrento Therapeutics, Inc. announced that it has received clearance from the FDA for its investigational new drug application for Abivertinib for the Phase II MAVERICK study to be conducted in participants with metastatic castrate resistant prostate cancer at multiple centers in the US.
    [Sorrento Therapeutics, Inc.]

    Press Release

    Idera Pharmaceuticals Shares Positive Results from Investigator-Sponsored Trial in Melanoma Patients at Amsterdam UMC

    Idera Pharmaceuticals, Inc. shared positive interim results from Amsterdam UMC, Vrije Universiteit Amsterdam, the Netherlands, regarding its investigator-sponsored trial, INTRIM 1, involving tilsotolimod, Idera’s synthetic Toll-like receptor 9 agonist.
    [Idera Pharmaceuticals, Inc.]

    Full Article

    Neurobiology of Brain Disorders

    August 7 – 12, 2022
    Castelldefels, Spain

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    Postdoctoral Fellow – Breast Cancer and Leukemia

    Duke University – Durham, North Carolina, United States

    Postdoctoral Fellow – Prostate Cancer Biology

    Marlene and Stewart Greenebaum Comprehensive Cancer Center – Baltimore, Maryland, United States

    Faculty Positions – Cancer Research

    Sidney Kimmel Cancer Center – Philadelphia, Pennsylvania, United States

    Scientific Officer – Cell Biology

    Institute of Cancer Research – London, United Kingdom

    Postdoctoral Position – Gynecologic Cancer

    Johns Hopkins University – Baltimore, Maryland, United States

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