 | | Vol. 11.19 – 18 May, 2022 |
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Stromal Notch Ligands Foster Lymphopenia-Driven Functional Plasticity and Homeostatic Proliferation of Naïve B Cells | In lymphopenic spleens, transferred B cells gradually lost their follicular phenotype and acquired characteristics of marginal zone B cells, as judged by cell surface phenotype, expression of integrins and chemokine receptors, and positioning close to the marginal sinus.
[Journal of Clinical Investigation] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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Locally Secreted BiTEs Complement CAR T Cells by Enhancing Killing of Antigen Heterogeneous Solid Tumors | Scientists detected the expression of tumor-associated epidermal growth factor receptor (EGFR), EGFR variant III, and interleukin-13 receptor alpha 2 on glioma tissues and CSCs.
[Molecular Therapy] |
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LGR4 Cooperates with PrPc to Endow the Stemness of Colorectal Cancer Stem Cells Contributing to Tumorigenesis and Liver Metastasis | Researchers reported that a leucine-rich repeat containing G protein-coupled receptor 4 (LGR4) cooperated with CD44 and PrPc; the latter contributed significantly to metastatic capacity and defined the stemness characteristics of colorectal CSCs.
[Cancer Letters] |
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Rationally Screened and Designed ABCG2-Binding Aptamers for Targeting Cancer Stem Cells and Reversing Multidrug Resistance | ATP-binding cassette, subfamily G, isoform 2 protein (ABCG2) glycosylated extracellular region-binding aptamers were efficiently screened by a cladded molecularly imprinted polymer-based in vitro screening method and further rationally engineered into cyclic bivalent aptamers.
[Analytical Chemistry] |
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PLGA-Nano-Encapsulated Disulfiram Inhibits Hypoxia-Induced NFκB, Cancer Stem Cells and Targets Glioblastoma in Vitro and in Vivo | The in vitro anti-glioblastoma (GBM) stem cell activity of disulfiram (DS) and in vivo anti-GBM efficacy of poly lactic-co-glycolic acid nanoparticle-encapsulated DS were examined.
[Molecular Cancer Therapeutics] |
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TFEB and TFE3 Depletion Increases Cancer Stem Cell Characteristics and EMT in Triple-Negative Breast Cancer | Scientists showed that knockout of TFEB and combined knockout of TFEB and TFE3 resulted in an increase in stem cell character and epithelial-mesenchymal transition, which could correlate to increased tumor metastasis and poorer prognosis.
[FASEB Journal] |
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Optimization of Production and Characterization of a Recombinant Soluble Human Cripto-1 Protein Inhibiting Self-Renewal of Cancer Stem Cells | The authors optimized the protocol for a T7 expression system, purification from inclusion bodies under denatured conditions refolding of a His-tagged Cripto-1 protein.
[Journal of Cellular Biochemistry] |
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Cytotoxic Effect of Disulfiram/Copper on Human Cervical Cancer Cell Lines and LGR5-Positive Cancer Stem-Like Cells | Scientists reported that high aldehyde dehydrogenase activity represented a functional marker for cervical CSCs.
[BMC Cancer] |
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ISG15 Enhances Glioma Cell Stemness by Promoting Oct4 Protein Stability | Loss of functional experiments indicated that ISG15 positively regulated glioma cell stemness, as evident by the increase of sphere formation ability, ALDH activity, stemness marker expression, and tumor-initiating ability.
[Environmental Toxicology] |
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ARL2 Is Required for Homologous Recombination Repair and Colon Cancer Stem Cell Survival | ARL2 expression was positively associated with the expression of all six RAD51 family genes, which were essential for homologous recombination repair.
[Febs Open Bio] |
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Lung Cancer Stem Cells and Their Clinical Implications | Mouse models of lung cancer have shown that lung CSCs reside in niches that are essential for the maintenance of stemness, plasticity, enable antitumor immune evasion, and provide metastatic potential.
[Cold Spring Harbor Perspectives in Medicine] |
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The Role of Cancer Stem Cell-Derived Exosomes in Cancer Progression | Studies have shown that CSC-derived exosomes carry a variety of gene mutations and specific epigenetic modifications indicative of unique cell phenotypes and metabolic pathways, enabling exchange of information in the tumor microenvironment to promote tumor invasion and metastasis.
[Stem Cell International] |
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Sorrento Announces FDA Authorization to Proceed With Phase II Study of Abivertinib (Fujovee™) to Treat Metastatic Castrate Resistant Prostate Cancer (MAVERICK Trial) | Sorrento Therapeutics, Inc. announced that it has received clearance from the FDA for its investigational new drug application for Abivertinib for the Phase II MAVERICK study to be conducted in participants with metastatic castrate resistant prostate cancer at multiple centers in the US.
[Sorrento Therapeutics, Inc.] |
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Idera Pharmaceuticals Shares Positive Results from Investigator-Sponsored Trial in Melanoma Patients at Amsterdam UMC | Idera Pharmaceuticals, Inc. shared positive interim results from Amsterdam UMC, Vrije Universiteit Amsterdam, the Netherlands, regarding its investigator-sponsored trial, INTRIM 1, involving tilsotolimod, Idera’s synthetic Toll-like receptor 9 agonist.
[Idera Pharmaceuticals, Inc.] |
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| August 7 – 12, 2022
Castelldefels, Spain |
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| Duke University – Durham, North Carolina, United States |
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| | Marlene and Stewart Greenebaum Comprehensive Cancer Center – Baltimore, Maryland, United States |
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| | Sidney Kimmel Cancer Center – Philadelphia, Pennsylvania, United States |
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| | Institute of Cancer Research – London, United Kingdom |
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| Johns Hopkins University – Baltimore, Maryland, United States |
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Cancer Stem Cell News
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