 | | Vol. 11.24 – 22 June, 2022 |
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| A large fraction of polyp and colorectal cancer (CRC) cells exhibited a stem-like phenotype, and investigators defined a continuum of epigenetic and transcriptional changes occurring in these stem-like cells as they progressed from homeostasis to CRC.
[Nature Genetics] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The expression of Oct4 variants was evaluated in brain cancer cell lines, and in brain tumor tissues, by quantitative real-time PCR, western blotting, and immunohistochemical analysis.
[Neuro-Oncology] |
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| The authors found that besides its described role in CDKN2A-dependent cell proliferation, EZH2 upheld the epithelial state of cancer cells by repressing the transcription of hundreds of mesenchymal genes.
[Oncogene] |
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| Scientists focused on the compounds without affecting cell viability and screened out three potential compounds that could significantly attenuate the stemness of breast cancer cells, as evident by the decrease of stemness marker expression.
[Cellular and Molecular Life Sciences] |
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| In human pituitary tumors, cells typified by expression of stemness markers, in particular SOX2 and SOX9, were found present in a wide variety of clinical tumor types, also showing a pronounced proliferative status.
[Endocrine-Related Cancer] |
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| Scientists characterized the presentation of CSCs and the interleukin-8 network in the adenoma/colorectal cancer epithelium using quantitative real-time PCR, immunohistochemistry, and double immunofluorescence.
[Biomedicine & Pharmacotherapy] |
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| Expression of the M2-like macrophage marker CD163 was evaluated by immunohistochemistry in human breast cancer tissues.
[Cell Communication and Signaling] |
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| Cell counting kit-8 assay, 5-ethynyl-2-deoxyuridine staining, transwell experiment, tube formation and sphere formation experiments were applied to detect gastric cancer cell proliferation, invasion, angiogenesis, and CSC characteristics.
[Cell Cycle] |
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| Tryptophan 2,3-dioxygenase (TDO2) expression was correlated with both progressive disease and clinical outcome, and its expression was an independent predictor of prognosis in GC.
[Pathobiology] |
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| Investigators summarize a variety of promising nanoparticles targeting the surface biomarkers of CSCs for the detection and eradication of tumor-initiating stem cells, used in combination with other treatment regimens.
[Journal of Controlled Release] |
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| The authors discuss the progress made and emerging opportunities of coupling advanced CRISPR screening systems with CSC models to reveal the understudied vulnerabilities of CSCs.
[Essays in Biochemistry] |
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| BioKey, ABVC’s wholly-owned subsidiary has entered into a Clinical Development Service Agreement with Rgene to guide three Rgene drug products for the treatment of cancer.
[ABVC Biopharma, Inc. (Globe Newswire, Inc.)] |
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| XBiotech, Inc. announced that it successfully completed the Phase I portion of its 1-BETTER study, a Phase I/II randomized, double-blind, placebo-controlled clinical study to evaluate its anti-cancer drug Natrunix in combination with chemotherapy for treating pancreatic cancer.
[XBiotech, Inc.] |
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| September 7 – 11 2022
Woods Hole, Massachusetts, United States |
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| | University of Bristol – Bristol, England, United Kingdom |
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| | The Institute of Cancer Research – London, England, United Kingdom |
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| | Sanford Research – Sioux Falls, South Dakota, United States |
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| | American Association for Cancer Research – Various, United States |
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| | University of Bristol – Bristol, England, United Kingdom |
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