Cancer Stem Cell News Volume 11.24 | Jun 22 2022


    2022-06-22 | CSCN 11.24

    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 11.24 – 22 June, 2022

    Single-Cell Analyses Define a Continuum of Cell State and Composition Changes in the Malignant Transformation of Polyps to Colorectal Cancer

    A large fraction of polyp and colorectal cancer (CRC) cells exhibited a stem-like phenotype, and investigators defined a continuum of epigenetic and transcriptional changes occurring in these stem-like cells as they progressed from homeostasis to CRC.
    [Nature Genetics]

    Full Article
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    Oct4A Palmitoylation Modulates Tumorigenicity and Stemness in Human Glioblastoma Cells

    The expression of Oct4 variants was evaluated in brain cancer cell lines, and in brain tumor tissues, by quantitative real-time PCR, western blotting, and immunohistochemical analysis.


    EZH2 Endorses Cell Plasticity to Non-Small Cell Lung Cancer Cells Facilitating Mesenchymal to Epithelial Transition and Tumor Colonization

    The authors found that besides its described role in CDKN2A-dependent cell proliferation, EZH2 upheld the epithelial state of cancer cells by repressing the transcription of hundreds of mesenchymal genes.


    Phenazine Derivatives Attenuate the Stemness of Breast Cancer Cells through Triggering Ferroptosis

    Scientists focused on the compounds without affecting cell viability and screened out three potential compounds that could significantly attenuate the stemness of breast cancer cells, as evident by the decrease of stemness marker expression.
    [Cellular and Molecular Life Sciences]


    Exploring Stem Cell Biology in Pituitary Tumors and Derived Organoids

    In human pituitary tumors, cells typified by expression of stemness markers, in particular SOX2 and SOX9, were found present in a wide variety of clinical tumor types, also showing a pronounced proliferative status.
    [Endocrine-Related Cancer]


    The Presentation and Regulation of the IL-8 Network in the Epithelial Cancer Stem-Like Cell Niche in Patients with Colorectal Cancer

    Scientists characterized the presentation of CSCs and the interleukin-8 network in the adenoma/colorectal cancer epithelium using quantitative real-time PCR, immunohistochemistry, and double immunofluorescence.
    [Biomedicine & Pharmacotherapy]

    Full ArticleGraphical Abstract

    Tumor-Associated Macrophages Promote Epithelial–Mesenchymal Transition and the Cancer Stem Cell Properties in Triple-Negative Breast Cancer through CCL2/AKT/β-Catenin Signaling

    Expression of the M2-like macrophage marker CD163 was evaluated by immunohistochemistry in human breast cancer tissues.
    [Cell Communication and Signaling]

    Full Article

    circFCHO2 Promotes Gastric Cancer Progression by Activating the JAK1/STAT3 Pathway via Sponging miR-194-5p

    Cell counting kit-8 assay, 5-ethynyl-2-deoxyuridine staining, transwell experiment, tube formation and sphere formation experiments were applied to detect gastric cancer cell proliferation, invasion, angiogenesis, and CSC characteristics.
    [Cell Cycle]


    Essential Roles of TDO2 in Gastric Cancer: TDO2 Is Associated with Cancer Progression, Patient Survival, PD-L1 Expression, and Cancer Stem Cells

    Tryptophan 2,3-dioxygenase (TDO2) expression was correlated with both progressive disease and clinical outcome, and its expression was an independent predictor of prognosis in GC.

    Webinar on Modeling arrhythmias using hPSC-derived cardiomyocytes

    Targeting Cancer Stem Cells: Therapeutic and Diagnostic Strategies by the Virtue of Nanoparticles

    Investigators summarize a variety of promising nanoparticles targeting the surface biomarkers of CSCs for the detection and eradication of tumor-initiating stem cells, used in combination with other treatment regimens.
    [Journal of Controlled Release]

    Full ArticleGraphical Abstract

    CRISPR Screening in Cancer Stem Cells

    The authors discuss the progress made and emerging opportunities of coupling advanced CRISPR screening systems with CSC models to reveal the understudied vulnerabilities of CSCs.
    [Essays in Biochemistry]


    ABVC BioPharma Expands Co-Development Partnership With Rgene Corporation

    BioKey, ABVC’s wholly-owned subsidiary has entered into a Clinical Development Service Agreement with Rgene to guide three Rgene drug products for the treatment of cancer.
    [ABVC Biopharma, Inc. (Globe Newswire, Inc.)]

    Press Release

    XBiotech Announces Successful Completion of Phase I Portion of Pancreatic Cancer Study

    XBiotech, Inc. announced that it successfully completed the Phase I portion of its 1-BETTER study, a Phase I/II randomized, double-blind, placebo-controlled clinical study to evaluate its anti-cancer drug Natrunix in combination with chemotherapy for treating pancreatic cancer.
    [XBiotech, Inc.]

    Press Release

    Channels in Context: Structure and Function of Ion Channels in Macromolecular Complexes and Native Cells

    September 7 – 11 2022
    Woods Hole, Massachusetts, United States

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    Research Associate – Cancer Biology

    University of Bristol – Bristol, England, United Kingdom

    Postdoctoral Training Fellow – Patient Derived Models

    The Institute of Cancer Research – London, England, United Kingdom

    Postdoctoral Position – Cancer Biology and Immunotherapies

    Sanford Research – Sioux Falls, South Dakota, United States

    Scientific Editor – Blood Cancer Discovery

    American Association for Cancer Research – Various, United States

    Research Associate – Cancer Biology

    University of Bristol – Bristol, England, United Kingdom

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