Cancer Stem Cell News Volume 11.25 | Jun 29 2022

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    2022-06-29 | CSCN 11.25


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 11.25 – 29 June, 2022
    TOP STORY

    CRISPR-Mediated MECOM Depletion Retards Tumor Growth by Reducing Cancer Stem Cell Properties in Lung Squamous Cell Carcinoma

    Forced expression of MECOM in lung squamous cell carcinoma cell lines promoted CSC properties, and its knockout inhibited CSC phenotypes.
    [Molecular Therapy]

    AbstractFull ArticleGraphical Abstract
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    PUBLICATIONSRanked by the impact factor of the journal

    Effects of Iron Modulation on Mesenchymal Stem Cell-Induced Drug Resistance in Estrogen Receptor-Positive Breast Cancer

    The authors utilized a co-culture model of bone marrow mesenchymal stem cells and estrogen receptor+ breast cancer cells to recapitulate interactions of cancer cells in bone marrow niches.
    [Oncogene]

    Abstract

    HERVs Characterize Normal and Leukemia Stem Cells and Represent a Source of Shared Epitopes for Cancer Immunotherapy

    Researchers used a reference of 14,968 human endogenous retroviruses (HERV) functional units to provide a thorough analysis of HERV expression in normal and acute myeloid leukemia bone marrow cells.
    [American Journal of Hematology]

    Abstract

    Toll-Like Receptor 2 Promotes Breast Cancer Progression and Resistance to Chemotherapy

    Scientists showed that high TLR2 expression is linked to poor prognosis in breast cancer patients, therefore representing a candidate target for breast cancer treatment.
    [Oncoimmunology]

    Full Article

    Garcinone C Suppresses Tumorsphere Formation and Invasiveness by Hedgehog/Gli1 Signaling in Colorectal Cancer Stem-Like Cells

    Researchers investigated the effect of garcinone C on cancer stemness and invasiveness in colorectal cancer; Gli1 was noted as pivotal in maintaining stemness and invasiveness in HCT116 and HT29 CSCs.
    [Journal of Agricultural and Food Chemistry]

    AbstractGraphical Abstract

    Cancer Stem Cell-Like Cells-Derived Exosomal CDKN2B-AS1 Stabilizes CDKN2B to Promote the Growth and Metastasis of Thyroid Cancer via TGF-β1/Smad2/3 Signaling

    Scientists investigated the role of cancer stem cell-like cells-derived exosomal CDKN2B-AS1 in thyroid cancer and the underlying regulatory mechanism.
    [Experimental Cell Research]

    Abstract

    CDC20 Regulates Sensitivity to Chemotherapy and Radiation in Glioblastoma Stem Cells

    CDC20 knockdown did not increase TMZ- and radiation-induced DNA damage, or alter DNA damage repair, but rather promoted cell death through accumulation of the pro-apoptotic protein, Bim.
    [PLoS One]

    Full Article

    Targeting CXCR4 to Suppress Glioma-Initiating Cells and Chemoresistance in Glioma

    The authors indicated that C-X-C motif chemokine receptor 4 (CXCR4) mediated the upregulation of Kruppel like factor 5, a zinc-finger-containing transcription factor, to facilitate the proliferation of glioma initiating cells.
    [Cell Biology International]

    Abstract

    Chelerythrine Chloride Inhibits Stemness of Melanoma Cancer Stem-Like Cells (CSCs) Potentially via Inducing Reactive Oxygen Species and Causing Mitochondria Dysfunction

    Researchers identified the antitumourigenic activities of the medicinal compound chelerythrine chloride (CHE) on melanoma CSCs. CHE induced apoptosis in A375 and A2058 CSCs.
    [Computational and Mathematical Methods in Medicine]

    Full Article
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    REVIEWS

    Stem Cell Theory of Cancer: Origin of Metastasis and Sub-Clonality

    Investigators discuss whether stem-ness enables metastasis or mutations drive metastasis. They ponder about low-grade versus high-grade tumors and about primary versus metastatic tumors.
    [Seminars in Diagnostic Pathology]

    Abstract
    INDUSTRY AND POLICY NEWS

    Panavance Therapeutics Announces Orphan Drug Designation for GP-2250 for the Treatment of Pancreatic Cancer

    Panavance Therapeutics, Inc. announced the US FDA has granted Orphan Drug Designation to GP-2250 for the treatment of all forms of pancreatic cancer.
    [Panavance Therapeutics, Inc.]

    Press Release

    $3.5M Study to Better Predict Prostate Cancer Risk

    To increase public understanding of the causes of prostate cancer, the University of Hawaiʻi Cancer Center will lead a $3.5 million public impact research study to further our understanding of prostate cancer to improve prediction of future disease.
    [University of Hawai’i News]

    Press Release
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    JOB OPPORTUNITIES

    Postdoctoral Fellow – Leukemia and Pancreatic Cancer Research

    University Health Network – Toronto, Ontario, Canada

    Research Associate Positions – Cancer Metabolism

    The Ohio State University Comprehensive Cancer Center – Columbus, Ohio, United States

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    University of Bristol – Bristol, England, United Kingdom

    Postdoctoral Training Fellow – Patient Derived Models

    Institute of Cancer Research – London, England, United Kingdom

    Postdoctoral Position – Cancer Biology and Immunotherapies

    Sanford Research – Sioux Falls, South Dakota, United States

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