Cancer Stem Cell News Volume 11.26 | Jul 6 2022

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    2022-07-06 | CSCN 11.26


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 11.26 – 6 July, 2022
    TOP STORY

    The Splicing Factor RBM17 Drives Leukemic Stem Cell Maintenance by Evading Nonsense-Mediated Decay of Pro-Leukemic Factors

    Scientists demonstrated that upregulation of the splicing factor, RBM17 preferentially marked and sustained leukemic stem cells and directly correlated with shorten patient survival.
    [Nature Communications]

    Full Article

    Explore this validated protocol for high-efficiency gene editing of Human Pluripotent Stem Cells using the ArciTect™ CRISPR-Cas9 System.
    PUBLICATIONSRanked by the impact factor of the journal

    Synaptotagmin 11 Scaffolds MKK7–JNK Signaling Process to Promote Stem-Like Molecular Subtype Gastric Cancer Oncogenesis

    The expression of Synaptotagmin in the tumor tissues of patients with gastric cancer was confirmed by performing Immunohistochemistry, and the correlation between the expression level and the patient’s survival rate was analyzed.
    [Journal of Experimental & Clinical Cancer Research]

    Full Article

    Galectin-1 Activates Carbonic Anhydrase IX and Modulates Glioma Metabolism

    Using Biolog microplate-1 mitochondrial functional assay, scientists confirmed that the depletion of Gal-1 increases the expression levels of the enzymes from the tricarboxylic acid (TCA) cycle, suggesting a reversal of the Warburg phenotype.
    [Cell Death & Disease]

    Full Article

    VEGF-B Targeting by Aryl Hydrocarbon Receptor Mediates the Migration and Invasion of Choriocarcinoma Stem-Like Cells

    Following VEGF-B knockdown or SR1 treatment, the proliferative, migratory, and invasive abilities of choriocarcinoma stem-like cells were significantly decreased, contrary to the findings after TCDD treatment.
    [Cancer Cell International]

    Full Article

    Gel-Free Single-Cell Culture Arrays on a Microfluidic Chip for Highly Efficient Expansion and Recovery of Colon Cancer Stem Cells

    Scientists developed a microfluidic chip ith 16,000 hydrophilic microchamber array, which could capture ∼2000 single cells at a time.
    [ACS Biomaterials Science & Engineering]

    AbstractGraphical Abstract

    Inhibitory Role of LINC00332 in Gastric Cancer Progression through Regulating Cell EMT and Stemness

    The gene expression patterns of gastric cancer (GC) from an RNAseq dataset were retrieved from the Gene Expression Omnibus database to recognize differentially expressed genes and lncRNAs between normal and GC samples through several bioinformatic analysis.
    [Life Sciences]

    AbstractGraphical Abstract

    Neogambogic Acid Suppresses Characteristics and Growth of Colorectal Cancer Stem Cells by Inhibition of DLK1 and Wnt/β-Catenin Pathway

    SW480 and HCT116 cells were treated with neogambogic acid at different concentrations and transfected with siDLK1 and pcDNA3.1-DLK1 plasmids.
    [European Journal of Pharmacology]

    Abstract

    TNF-α-Inducing Protein of Helicobacter pylori Promotes EMT and Cancer Stem-Like Cells Properties via Activation of Wnt/β-Catenin Signaling Pathway in Gastric Cancer Cells

    To investigate the carcinogenic mechanisms of Tipα, SGC7901 cells and SGC7901-derived cancer stem-like cells were stimulated by recombinant Tipα protein with or without Wnt/β-catenin signaling inhibitor XAV939.
    [Pathogens and Disease]

    Abstract

    Mex3a Marks Drug-Tolerant Persister Colorectal Cancer Cells That Mediate Relapse after Chemotherapy

    Patient-derived organoids expand from highly proliferative LGR5+ tumor cells; however, scientists discovered that lack of optimal growth conditions specified a latent LGR5+ cell state.
    [Nature Cancer]

    Abstract

    REVIEWS

    Advances in the Pathogenesis and Clinical Application Prospects of Tumor Biomolecules in Keloid

    The authors summarize tumor biomolecules in keloids from the perspectives of liquid biopsy, genetics, proteomics and epigenetics and to investigate their mechanisms of action and feasibility from bench to bedside.
    [Burns & Trauma]

    Full Article
    INDUSTRY AND POLICY NEWS

    BriaCell Partners with Waisman Biomanufacturing to Manufacture and Supply Prostate Cancer Immunotherapy

    BriaCell Therapeutics Corp. has entered a manufacturing service agreement with Waisman Biomanufacturing at the University of Wisconsin–Madison, to manufacture Bria-Pros, BriaCell’s off-the-shelf personalized immunotherapy for prostate cancer, for anticipated use in clinical studies.
    [BriaCell Therapeutics Corp.]

    Press Release

    PhD Student Earns Regional MALTO Conference Presentation Award for Work on Synthetic Compound Inhibiting Growth, Spread of Cancer Stem Cells

    Haowen Zhang, a PhD student in the Pharmaceutical Sciences-Medicinal Chemistry Concentration degree program, earned the Robert A. Magarian Outstanding Podium Presentation Award at the 47th Annual MALTO Medicinal Chemistry Pharmacognosy Meeting.
    [Univerity of Houston]

    Press Release
    FEATURED EVENT

    Pacific Northwest Prostate Cancer Conference

    October 15, 2022
    Virtual

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    JOB OPPORTUNITIES

    Associate Professor – Oncology

    Fred Hutchinson Cancer Research Center – Seattle, Washington, United States

    Principal Scientist – Cancer Immunology Drug Discovery

    Boehringer Ingelheim – Vienna, Austria

    Postdoctoral Fellow – Leukemia and Pancreatic Cancer Research

    University Health Network – Toronto, Ontario, Canada

    Postdoctoral Training Fellow – Patient Derived Models

    Institute of Cancer Research – London, England, United Kingdom

    Postdoctoral Position – Cancer Biology and Immunotherapies

    Sanford Research – Sioux Falls, South Dakota, United States

    > See All Jobs

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