Cancer Stem Cell News Volume 11.29 | Jul 27 2022

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    2022-07-27 | CSCN 11.29


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 11.29 – 27 July, 2022
    TOP STORY

    Fusion between Glioma Stem Cells and Mesenchymal Stem Cells Promotes Malignant Progression in 3D-Bioprinted Models

    Cell fusion between glioma stem cells and mesenchymal stem cells was found by the method of Cre-LoxP switch gene and RFP/GFP dual-color fluorescence tracing.
    [ACS Applied Materials & interfaces]

    AbstractGraphical Abstract
    New human primary cancer-sourced blood products, immune cell subsets, and more. Click to view products.
    PUBLICATIONSRanked by the impact factor of the journal

    KS10076, a Chelator for Redox-Active Metal Ions, Induces ROS-Mediated STAT3 Degradation in Autophagic Cell Death and Eliminates ALDH1+ Stem Cells

    Patient-derived organoid models demonstrated that KS10076 efficiently represses cancer cells with active KRAS, and fluorouracil resistance, which suggested clinical advantages.
    [Cell Reports]

    AbstractGraphical Abstract

    Lactate Promotes Metastasis of Normoxic Colorectal Cancer Stem Cells through PGC-1α-Mediated Oxidative Phosphorylation

    The abundance of hypoxic and normoxic CSCs was analyzed in primary colorectal cancer tumors. It was found that the proportion of normoxic CSCs was positively associated with tumor stage.
    [Cell Death & Disease]

    Full Article

    The Repression of Oncoprotein SET by the Tumor Suppressor p53 Reveals a p53-SET-PP2A Feedback Loop for Cancer Therapy

    Investigators identified the tumor suppressor p53 as a key regulator that transcriptionally repressed the expression of SET in both normal and cancer cells.
    [Science China Life Sciences]

    Abstract

    Targeting the mRNA Endonuclease CPSF73 Inhibits Breast Cancer Cell Migration, Invasion and Self-Renewal

    The authors reported that a HECT-like E3 ligase, UBE3D, participated in stabilizing CPFS73 protein by preventing its ubiquitin-mediated degradation by the proteasome.
    [iScience]

    AbstractGraphical Abstract

    PI3Kδ Activity Controls Plasticity and Discriminates between EMT and Stemness Based on Distinct TGFβ Signaling

    Based on 3D organoid culture of hepatocellular carcinoma-derived cell lines and AAV8-based protein overexpression in the mouse liver, investigators showed that activity modulation of isoform δ of phosphoinositide 3-kinase (PI3Kδ) controls differentiation and discriminates between stemness.
    [Communications Biology]

    Full Article

    Efficacy of Cancer-Specific Anti-Podoplanin CAR-T Cells and Oncolytic Herpes Virus G47Δ Combination Therapy against Glioblastoma

    LpMab-2 (Lp2)-chimeric antigen receptor (CAR) transduced T cells (Lp2-CAR-T) specifically targeted podoplanin (PDPN)-expressing glioma cells, while sparing the PDPN-expressing normal cells. Lp2-CAR-T also killed patient-derived glioma stem cells, demonstrating its clinical potential against glioblastoma.
    [Molecular Therapy-Oncolytics]

    AbstractFull ArticleGraphical Abstract

    Nonviral McDna-Mediated Bispecific CAR T Cells Kill Tumor Cells in an Experimental Mouse Model of Hepatocellular Carcinoma

    Investigators respectively detected the in vitro and in vivo tumor-suppression efficacy of chimeric antigen receptor (CAR) T cells through the CCK-8 assays and the hepatocellular carcinoma xenograft mice models.
    [BMC Cancer]

    Full Article

    In Situ Detection of Protein-Protein Interaction by Proximity Ligation Assay in Patient Derived Brain Tumor Stem Cells

    The authors described an adapted proximity ligation assay protocol for the assessment of galectin-1-HOXA5 interaction in brain tumor stem cells.
    [STAR Protocols]

    Full Article
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    REVIEWS

    Prostate Cancer as a Dedifferentiated Organ: Androgen Receptor, Cancer Stem Cells, and Cancer Stemnes

    Investigators discuss prostate cancer (PCa) from the perspective of an abnormal organ with increasingly deregulated differentiation, and discuss the role of androgen receptor signaling during PCa progression<.br/>[Essays in Biochemistry]

    Abstract
    INDUSTRY AND POLICY NEWS

    US FDA Approves QBiotics Investigational New Drug Application to Initiate Tigilanol Tiglate Soft Tissue Sarcoma Phase II Trial

    QBiotics Group Limited has been granted approval of its Investigational New Drug application by the US FDA for lead oncology molecule, tigilanol tiglate.
    [QBiotics Group Limited]

    Press Release

    Kite’s CAR T-Cell Therapy Tecartus® Receives Positive CHMP Opinion in Relapsed or Refractory Acute Lymphoblastic Leukemia (r/r ALL)

    Kite announced that the European Medicines Agency Committee for Medicinal Products for Human Use (CHMP) has issued a positive opinion for Tecartus® for the treatment of adult patients 26 years of age and above with r/r ALL.
    [Gilead Sciences, Inc.]

    Press Release
    FEATURED EVENT

    The Lung Epithelium Conference: In Health and Disease

    Aug 7 – 12, 2022
    Saxtons River, Vermont, United States

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    JOB OPPORTUNITIES

    Postdoctoral Position – Cancer Biology and Immunotherapies

    Sanford Research – Sioux Falls, South Dakota, United States

    Faculty Position – Cancer Biology

    Mayo Clinic – Scottsdale, Arizona, United States

    Postdoctoral Scholar – Protein Degradation in Cancer and Alzheimer’s

    Virginia Commonwealth University – Richmond, Virginia, United States

    Principal Scientist – Cancer Immunology Drug Discovery

    Boehringer Ingelheim – Vienna, Austria

    Associate Professor – Thematic Research Programs

    The Chinese University of Hong Kong – Hong Kong, China

    > See All Jobs

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