| Vol. 11.31 – 31 August, 2022 |
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| The authors showed that type I interferons (IFNs) functioned as molecular hubs of resistance during immunogenic chemotherapy, triggering the epigenetic regulator demethylase 1B (KDM1B) to promote an adaptive, yet reversible, transcriptional rewiring of cancer cells towards stemness, and immune escape. [Nature Immunology] |
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PUBLICATIONSRanked by the impact factor of the journal |
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| Glioblastoma exhibited a high level of heterogeneity with diverse subtypes of cells within the tumor, enabling immune infiltration and different degrees of interactions with the tumor. [ACS Nano] |
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| Investigators performed integrative analysis of single-cell transcriptomic profiling, paired T cell receptor sequencing, and spatial transcriptomic profiling on tuberous sclerosis complex associated tumors with mTORC1 hyperactivity. [Nature Communications] |
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| The authors characterized the MHC I-associated peptide (MAP) repertoire of human induced pluripotent stem cells (PSCs) using proteogenomics. Their analyses revealed a set of 46 pluripotency-associated MAPs absent from the transcriptome of normal tissues and adult stem cells but expressed in PSCs and multiple adult cancers. [Cell Reports] |
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| Using a multi-allelic mouse model of IDH1-mutant acute myeloid leukemia, investigators demonstrated that the clinical IDH1 inhibitor AG-120 exerted cell-type-dependent effects on leukemic cells, promoting delayed disease regression. [Cell Reports] |
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| Scientists found that WEE1 expression was upregulated in ovarian cancer spheroids because of the decreased expression of miR-424 and miR-503, which directly targeted WEE1. [Molecular Therapy-Nucleic Acids] |
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| The authors showed, in human glioblastoma biopsies, that increased expression of Fragile X Messenger Ribonucleoprotein directly correlated with a worse patient outcome. [Cell Death & Disease] |
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| Researchers reported that exosomes released from glioma stem-like cells contained a significant increasing level of miR-155-5p and could be horizontally transferred to surrounding glioma cells. [Cell Death & Disease] |
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| Scientists showed that bladder cancer stem-like cells were at slow-cycling state with enhanced autophagy and mitophagy. [iScience] |
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| The authors investigated Znhit1 and HIF-2α gene expression in breast cancer tissues as well as their relation to CSC markers LGR5, ALDH1A1 and β-catenin in tissue and serum of breast cancer patients. [Scientific Reports] |
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| Fetal-like reprogramming has been demonstrated in the tumour microenvironment, indicating extraordinary cellular plasticity and bringing an additional layer of cellular heterogeneity. [Nature Reviews Cancer] |
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| Populations of treatment-resistant CSCs are well characterized in oral squamous cell carcinoma. These populations of CSCs engage the cellular program known as epithelial-mesenchymal transition to enhance metastatic spread and therapeutic resistance. [Biochemical Pharmacology] |
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| The National Foundation for Cancer Research announced today that Dr. Rakesh K. Jain has been selected to receive the 2022 Szent-Györgyi Prize for Progress in Cancer Research. [National Foundation for Cancer Research] |
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| Henry Ford Health and Michigan State University (MSU) Health Sciences announced its funding of five cancer research grants of up to $100,000 each. [Michigan State University] |
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| November 1- 6, 2022 Orlando, Florida, United States |
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| The University of Oklahoma – Oklahoma City, Oklahoma, United States |
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| University of California San Francisco – San Francisco, California, United States |
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| German Cancer Research Center in the Helmholtz Association – Heidelberg, Germany |
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| The University of Oklahoma – Oklahoma City, Oklahoma, United States |
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| Baylor College of Medicine – Houston, Texas, United States |
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