Cancer Stem Cell News Volume 11.31 | Aug 31 2022


    2022-08-31 | CSCN 11.31

    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 11.31 – 31 August, 2022

    Type I IFNs Promote Cancer Cell Stemness by Triggering the Epigenetic Regulator KDM1B

    The authors showed that type I interferons (IFNs) functioned as molecular hubs of resistance during immunogenic chemotherapy, triggering the epigenetic regulator demethylase 1B (KDM1B) to promote an adaptive, yet reversible, transcriptional rewiring of cancer cells towards stemness, and immune escape.
    [Nature Immunology]

    Full Article
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    Molecular Crosstalk between T Cells and Tumor Uncovers GBM-Specific T Cell Signatures in Blood: Noninvasive GBM Diagnosis Using Immunosensors

    Glioblastoma exhibited a high level of heterogeneity with diverse subtypes of cells within the tumor, enabling immune infiltration and different degrees of interactions with the tumor.
    [ACS Nano]

    AbstractGraphical Abstract

    Midkine Expression by Stem-Like Tumor Cells Drives Persistence to mTOR Inhibition and an Immune-Suppressive Microenvironment

    Investigators performed integrative analysis of single-cell transcriptomic profiling, paired T cell receptor sequencing, and spatial transcriptomic profiling on tuberous sclerosis complex associated tumors with mTORC1 hyperactivity.
    [Nature Communications]

    Full Article

    Induced Pluripotent Stem Cells Display a Distinct Set of MHC I-Associated Peptides Shared by Human Cancers

    The authors characterized the MHC I-associated peptide (MAP) repertoire of human induced pluripotent stem cells (PSCs) using proteogenomics. Their analyses revealed a set of 46 pluripotency-associated MAPs absent from the transcriptome of normal tissues and adult stem cells but expressed in PSCs and multiple adult cancers.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Inhibition of Mutant IDH1 Promotes Cycling of Acute Myeloid Leukemia Stem Cells

    Using a multi-allelic mouse model of IDH1-mutant acute myeloid leukemia, investigators demonstrated that the clinical IDH1 inhibitor AG-120 exerted cell-type-dependent effects on leukemic cells, promoting delayed disease regression.
    [Cell Reports]

    Full ArticleGraphical Abstract

    MicroRNA-Dependent Inhibition of WEE1 Controls Cancer Stem-Like Characteristics and Malignant Behavior in Ovarian Cancer

    Scientists found that WEE1 expression was upregulated in ovarian cancer spheroids because of the decreased expression of miR-424 and miR-503, which directly targeted WEE1.
    [Molecular Therapy-Nucleic Acids]

    AbstractGraphical Abstract

    FMRP Modulates the Wnt Signaling Pathway in Glioblastoma

    The authors showed, in human glioblastoma biopsies, that increased expression of Fragile X Messenger Ribonucleoprotein directly correlated with a worse patient outcome.
    [Cell Death & Disease]

    Full Article

    Exosomal miR-155-5p Derived From Glioma Stem-Like Cells Promotes Mesenchymal Transition via Targeting ACOT12

    Researchers reported that exosomes released from glioma stem-like cells contained a significant increasing level of miR-155-5p and could be horizontally transferred to surrounding glioma cells.
    [Cell Death & Disease]

    Full Article

    MCM7 Supports the Stemness of Bladder Cancer Stem-Like Cells by Enhancing Autophagic Flux

    Scientists showed that bladder cancer stem-like cells were at slow-cycling state with enhanced autophagy and mitophagy.

    AbstractFull ArticleGraphical Abstract

    Znhit1 and HIF-2α Are Correlated with Cancer Stem Cell Markers in Breast Cancer Patients

    The authors investigated Znhit1 and HIF-2α gene expression in breast cancer tissues as well as their relation to CSC markers LGR5, ALDH1A1 and β-catenin in tissue and serum of breast cancer patients.
    [Scientific Reports]

    Full Article

    Oncofetal Reprogramming in Tumor Development and Progression

    Fetal-like reprogramming has been demonstrated in the tumour microenvironment, indicating extraordinary cellular plasticity and bringing an additional layer of cellular heterogeneity.
    [Nature Reviews Cancer]


    Cancer Stem Cell Plasticity and Its Implications in the Development of New Clinical Approaches for Oral Squamous Cell Carcinoma

    Populations of treatment-resistant CSCs are well characterized in oral squamous cell carcinoma. These populations of CSCs engage the cellular program known as epithelial-mesenchymal transition to enhance metastatic spread and therapeutic resistance.
    [Biochemical Pharmacology]

    Full ArticleGraphical Abstract

    Pioneering Engineer-Researcher to Receive 2022 Szent-Györgyi Prize for Progress in Cancer Research

    The National Foundation for Cancer Research announced today that Dr. Rakesh K. Jain has been selected to receive the 2022 Szent-Györgyi Prize for Progress in Cancer Research.
    [National Foundation for Cancer Research]

    Press Release

    Henry Ford Health + MSU Health Sciences Funds Five Cancer Research Grants

    Henry Ford Health and Michigan State University (MSU) Health Sciences announced its funding of five cancer research grants of up to $100,000 each.
    [Michigan State University]

    Press Release

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    Research Assistant Professor – Pancreatic Cancer Metabolism

    The University of Oklahoma – Oklahoma City, Oklahoma, United States

    Postdoctoral Scholar – Oncology

    University of California San Francisco – San Francisco, California, United States

    PhD Position – Tumor Heterogeneity

    German Cancer Research Center in the Helmholtz Association – Heidelberg, Germany

    Research Assistant Professor – Pancreatic Cancer Metabolism

    The University of Oklahoma – Oklahoma City, Oklahoma, United States

    Faculty Positions – Center for Cancer Neuroscience

    Baylor College of Medicine – Houston, Texas, United States

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