 | | Vol. 11.32 – 7 September, 2022 |
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| Using gene silencing and therapeutic activation of p53, researchers analyzed the cell cycle profiles and apoptosis levels of CSCs in mucoepidermoid carcinoma cell lines via flow cytometry and looked at the effects on survival/self-renewal of the CSCs through sphere assays.
[Clinical Cancer Research] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators identified Miat as an lncRNA enriched in the sonic hedgehog group of medulloblastoma that was required for maintenance of a treatment-resistant stem-like phenotype in the disease.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| The 3D extracellular matrix could mediate cytoskeletal F-actin bundling through biomechanical force associated receptors integrin β1, contributing to the release of E3 ligase Tripartite motif protein 11 from cytoskeleton and degradation of the glycolytic rate-limiting enzyme phosphofructokinase.
[Cancer Science] |
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| Scientists showed that exogenous leukocyte cell-derived chemotaxin 2 treatment inhibited CSC functions such as tumor sphere formation and drug efflux.
[Journal of Biological Chemistry] |
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| The effects of rolipram, a PDE4 inhibitor, were evaluated on PI3K regulators and signaling. The efficacy of rolipram was compared with paclitaxel, an anticancer drug that was ineffective in obliterating breast CSCs.
[Journal of Cellular Biochemistry] |
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| Investigators discovered that cancer-associated fibroblasts-exosomes remarkably enhanced prostate cancer cell migration, invasion, stemness, epithelial-mesenchymal transition, and metastasis.
[Cell Death Discovery] |
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| By analyzing a database and verifying with their clinical specimens, scientists found that RNF126 was highly expressed in hepatocellular carcinoma tissues, which was associated with shorter overall survival and higher recurrence rate.
[Human Cell] |
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| The authors assessed the anti-cancer cell and anti-CSC effects of GANT61, and its regulatory influence on the Wnt/β‑catenin and Notch signaling pathways in colorectal cancer.
[Oncology Reports] |
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| In lung adenocarcinoma cells, proliferation and stem cell sphere-formation that were attenuated by LINC01419 knockdown were discovered to be facilitated by LINC01419 overexpression.
[Biology Direct] |
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| Complex crosstalk occurs between tumor-associated macrophages (TAMs) and liver cancer cells. TAMs play indispensable roles in tumor progression, angiogenesis, and autophagy due to their heterogeneity and robust plasticity.
[Cancer Communications] |
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| Immutep Limited announced it has signed a Material Transfer Agreement with the Maria Skłodowska-Curie National Research Institute of Oncology in Warsaw, Poland to enable an investigator-initiated open label Phase II clinical trial.
[Immutep Limited] |
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| The results of the Next Generation Cancer Immunotherapy: Targeting the Tumor Microenvironment funding call are out. 20 consortia were selected for funding with a total amount of €25.9 million. Two of these were Rosalind and Morris Goodman Cancer Institute researchers, Professors Daniela Quail and Morag Park.
[McGill Reporter] |
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| December 3-7, 2022
Washington, DC, United States |
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| | Icahn School of Medicine at Mount Sinai – New York City, New York, United States |
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| | Gunderson Health System – La Crosse, Wisconsin, United States |
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| | The University of Oklahoma – Oklahoma City, Oklahoma, United States |
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| | University of California San Francisco – San Francisco, California, United States |
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| | German Cancer Research Center in the Helmholtz Association – Heidelberg, Germany |
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