Cancer Stem Cell News Volume 11.33 | Sep 14 2022


    2022-09-14 | CSCN 11.33

    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 11.33 – 14 September, 2022

    Comparative Roadmaps of Reprogramming and Oncogenic Transformation Identify Bcl11b and Atoh8 As Broad Regulators of Cellular Plasticity

    The authors deconvoluted the cellular trajectories of reprogramming and transformation at the single-cell resolution, and revealed how the two processes intersected before they bifurcated.
    [Nature Cell Biology]

    Full Article

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    Caspase-3–Induced Activation of SREBP2 Drives Drug Resistance via Promotion of Cholesterol Biosynthesis in Hepatocellular Carcinoma

    SREBP2-mediated cholesterol biosynthesis was crucial for the augmentation of liver CSCs, and loss of SREBP2 conferred sensitivity to tyrosine kinase inhibitors.
    [Cancer Research]


    Fucoidan from Sargassum hemiphyllum Inhibits the Stemness of Cancer Stem Cells and Epithelial-Mesenchymal Transitions in Bladder Cancer Cells

    Fucoidan downregulated the expression of vimentin, a mesenchymal marker, upregulated the expression of E-cadherin, an epithelial marker, and decreased the formation of filopodia and lamellipodia.
    [International Journal of Biological Macromolecules]


    Differential Expression of Hepatic Cancer Stemness and Hypoxia Markers in Residual Cancer After Locoregional Therapies for Hepatocellular Carcinoma

    Scientists investigated the differential expression of hepatic CSCs and hypoxia in residual hepatocellular carcinoma after transarterial chemoembolization in comparison to transarterial radioembolization.
    [Hepatology Communications]

    Full Article

    PARP1 Inhibition by Olaparib Reduces the Lethality of Pancreatic Cancer Cells and Increases Their Sensitivity to Gemcitabine

    Viability, radiosensitization, angiogenesis, migration, colony formation, TUNEL, cell cycle, multicellular tumorsphere induction, and in vivo assays were performed to test the influence of Poly (ADP-ribose) polymerase 1 (PARP1) inhibition on resistance phenomena and tumor progression.
    [Biomedicine & Pharmacotherapy]

    Full ArticleGraphical Abstract

    Glioma Stem Cell Signature Predicts the Prognosis and the Response to Tumor Treating Fields Treatment

    Single-cell RNA sequencing was used to identify the glioma stem cell related genes, then machine learning methods were applied for clustering and validation.
    [CNS Neuroscience & Therapeutics]

    Full Article

    A New Triazolothiadiazine Derivative Inhibits Stemness and Induces Cell Death in HCC by Oxidative Stress Dependent JNK Pathway Activation

    The authors investigated the cellular bioactivities of a series of triazolothiadiazine derivatives on hepatocellular carcinoma (HCC).
    [Scientific Reports]

    Full Article

    Palladin Promotes Cancer Stem Cell-Like Properties in Lung Cancer by Activating Wnt/Β-Catenin Signaling

    Immunofluorescence, flow fluorescence assay, and Western blot were performed to detect Palladin expression in six non-small cell lung cancer cell lines.
    [Cancer Medicine]

    Full Article

    An Experimental Model for Ovarian Cancer: Propagation of Ovarian Cancer Initiating Cells and Generation of Ovarian Cancer Organoids

    Tumor tissues were collected, and OCT4, SOX2, and NANOG expressions were assessed by immunohistochemistry staining to investigate the association of stemness markers with overall survival.
    [BMC Cancer]

    Full Article
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    Functions and Underlying Mechanisms of lncRNA HOTAIR in Cancer Chemotherapy Resistance

    The authors review the mechanisms underlying homeobox transcript antisense intergenic RNA HOTAIR-related drug resistance, discuss the limitations of current knowledge, and propose potential future directions.
    [Cell Death Discovery]

    Full Article

    The Emerging Roles of Circular RNA-Mediated Autophagy in Tumorigenesis and Cancer Progression

    The emerging regulatory roles and mechanisms of circular RNAs in autophagy are summarized, and the effects of autophagy-associated circular RNAs on cancer development are described.
    [Cell Death Discovery]

    Full Article

    Agenus Initiates Botensilimab Phase II ACTIVATE Trials in Advanced MSS Colorectal Cancer and Advanced Melanoma

    Agenus announced the initiation of a global Phase II program of botensilimab, an Fc-enhanced anti-CTLA-4 that activates innate and adaptive immune responses.

    Press Release

    US Enlists IMB To Seek New Ways To Battle Melanoma

    Researchers from the Institute for Molecular Bioscience (IMB) have been awarded international funding to combat an expected escalation of skin cancer cases in US troops who served in Iraq and Afghanistan.
    [University of Queensland]

    Press Release

    Diet, Nutrition and Cancer Cell Metabolism

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    Assistant Professor – Stem Cell Biology

    University of California Santa Cruz – Santa Cruz, California, United States

    Postdoctoral Research Scientist – Bioinformatics

    Columbia University – New York, New York, United States

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    Stanford Medicine – Stanford, California, United States

    Faculty Member – Faculty of Life and Health Sciences

    Shenzhen Institute of Advanced Technology – Shenzhen, China

    Research Scientist – Inflammation

    Gilead Sciences, Inc. – Foster City, California, United States

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