 | | Vol. 11.33 – 14 September, 2022 |
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| The authors deconvoluted the cellular trajectories of reprogramming and transformation at the single-cell resolution, and revealed how the two processes intersected before they bifurcated.
[Nature Cell Biology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| SREBP2-mediated cholesterol biosynthesis was crucial for the augmentation of liver CSCs, and loss of SREBP2 conferred sensitivity to tyrosine kinase inhibitors.
[Cancer Research] |
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| Fucoidan downregulated the expression of vimentin, a mesenchymal marker, upregulated the expression of E-cadherin, an epithelial marker, and decreased the formation of filopodia and lamellipodia.
[International Journal of Biological Macromolecules] |
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| Scientists investigated the differential expression of hepatic CSCs and hypoxia in residual hepatocellular carcinoma after transarterial chemoembolization in comparison to transarterial radioembolization.
[Hepatology Communications] |
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| Viability, radiosensitization, angiogenesis, migration, colony formation, TUNEL, cell cycle, multicellular tumorsphere induction, and in vivo assays were performed to test the influence of Poly (ADP-ribose) polymerase 1 (PARP1) inhibition on resistance phenomena and tumor progression.
[Biomedicine & Pharmacotherapy] |
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| Single-cell RNA sequencing was used to identify the glioma stem cell related genes, then machine learning methods were applied for clustering and validation.
[CNS Neuroscience & Therapeutics] |
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| The authors investigated the cellular bioactivities of a series of triazolothiadiazine derivatives on hepatocellular carcinoma (HCC).
[Scientific Reports] |
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| Immunofluorescence, flow fluorescence assay, and Western blot were performed to detect Palladin expression in six non-small cell lung cancer cell lines.
[Cancer Medicine] |
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| Tumor tissues were collected, and OCT4, SOX2, and NANOG expressions were assessed by immunohistochemistry staining to investigate the association of stemness markers with overall survival.
[BMC Cancer] |
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| The authors review the mechanisms underlying homeobox transcript antisense intergenic RNA HOTAIR-related drug resistance, discuss the limitations of current knowledge, and propose potential future directions.
[Cell Death Discovery] |
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| The emerging regulatory roles and mechanisms of circular RNAs in autophagy are summarized, and the effects of autophagy-associated circular RNAs on cancer development are described.
[Cell Death Discovery] |
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| Agenus announced the initiation of a global Phase II program of botensilimab, an Fc-enhanced anti-CTLA-4 that activates innate and adaptive immune responses.
[Agenus] |
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| Researchers from the Institute for Molecular Bioscience (IMB) have been awarded international funding to combat an expected escalation of skin cancer cases in US troops who served in Iraq and Afghanistan.
[University of Queensland] |
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| October 24 – 26, 2022
Madrid, Spain |
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| | University of California Santa Cruz – Santa Cruz, California, United States |
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| | Columbia University – New York, New York, United States |
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| | Stanford Medicine – Stanford, California, United States |
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| | Shenzhen Institute of Advanced Technology – Shenzhen, China |
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| | Gilead Sciences, Inc. – Foster City, California, United States |
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