 | | Vol. 11.36 – 5 October, 2022 |
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| Scientists found that the compositions of ribosomes of glioblastoma cells in the tumour core and edge differed due to alternative RNA splicing. The acidic pH in the core switched before messenger RNA splicing of the ribosomal gene RPL22L1 towards the RPL22L1b isoform.
[Nature Cell Biology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators revealed that TGFB2-AS1 impaired the breast cancer stem-like cell traits of TNBC cells in vitro and dramatically decreases tumorigenic frequency and lung metastasis in vivo.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| The expression of HIF-1α was significantly elevated in highly dense glioblastoma cells, even under non-hypoxic conditions. Atypical HIF-1α expression was associated with the Notch1 signaling pathway in both glioblastoma and glioblastoma stem cells.
[Cellular and Molecular Life Sciences] |
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| SNAI1 knockout cells exhibited plasticity in differentiation, drifting towards the luminal phenotype, gained stemness potential, and could differentiate into acinar mammospheres in 3D culture.
[Cell Death & Disease] |
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| Cancer stemness of glioma cells was investigated by sphere formation assays, clone formation assays, and xenograft tumor formation assays. The expression of RIP2, p-NF-κB, IκBα, CD133, or SOX-2 was detected by Western blotting and immunofluorescence.
[CNS Neuroscience & Therapeutics] |
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| HepG2 cells were administered with three different concentrations of folic acid for 10 days. Fluorescence-activated cell sorting was done to evaluate cell viability and apoptosis. Agarose-coated plates were used to access cancer stem cells number.
[Scientific Reports] |
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| Researchers used a 4T1-Luc allograft BALB/c syngeneic mouse model and 4T1-Luc and MDA-MB-231 cells for histological analysis, qRT-PCR, western blotting, reactive oxygen species analysis, mammosphere formation analysis, and monolayer fluorescence imaging analysis.
[Scientific Reports] |
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| Thioridazine demonstrated the capability of destroying breast cancer stem cells and this effect was amplified when combined with carboplatin treatment.
[Translational Oncology] |
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| Investigators reported establishing a novel cell line, BAG50, with stemness properties. Chemotherapy-enriched sphere-forming cells with CSC properties isolated from a patient with gastric cancer were cultured in a serum-containing medium and passaged for up to 51 passages.
[Medical Oncology] |
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| Since normal cells do not experience high levels of stress under physiological conditions, targeting cancer fitness genes is less likely to cause toxicity to noncancerous tissues. Therefore, investigators summarize the key features and function of cancer fitness genes and discuss their therapeutic potential.
[Trends in Cancer] |
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| The authors summarize the characteristics of gastrointestinal CSCs and review the latest research in treating gastrointestinal malignant tumors using polymer nanoparticles to target cancer stem cells.
[Stem Cell Research & Therapy] |
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| Abcuro, Inc. announced initiation of a Phase I/II dose escalation trial to evaluate the safety, tolerability, and proof-of-concept of ABC008 in patients with T cell large granular lymphocytic leukemia who suffer from anemia and/or neutropenia.
[Abcuro, Inc.] |
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| Cue Biopharma, Inc. announced that the FDA has granted Fast Track designation to CUE-101 for the treatment of patients with human papilloma virus recurrent/metastatic head and neck squamous cell carcinoma as a monotherapy and in combination with pembrolizumab.
[Cue Biopharma, Inc.] |
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| November 6 – 8, 2022
Seville, Spain |
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| | University of Illinois Chicago – Chicago, Illinois, United States |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | Netherlands Cancer Institute (AVL) – Amsterdam, Netherlands |
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| | CRUK Beatson Institute for Cancer Research – Glasgow, United Kingdom |
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| | Stanford Medicine – Stanford, California, United States |
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