Cancer Stem Cell News Volume 11.36 | Oct 5 2022

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    2022-10-05 | CSCN 11.36


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 11.36 – 5 October, 2022
    TOP STORY

    Alternative RNA Splicing Modulates Ribosomal Composition and Determines the Spatial Phenotype of Glioblastoma Cells

    Scientists found that the compositions of ribosomes of glioblastoma cells in the tumour core and edge differed due to alternative RNA splicing. The acidic pH in the core switched before messenger RNA splicing of the ribosomal gene RPL22L1 towards the RPL22L1b isoform.
    [Nature Cell Biology]

    Full Article
    ON987CXN-oct-728x90-2022
    PUBLICATIONSRanked by the impact factor of the journal

    TGFB2-AS1 Inhibits Triple-Negative Breast Cancer Progression via Interaction With SMARCA4 and Regulating Its Targets TGFB2 and SOX2

    Investigators revealed that TGFB2-AS1 impaired the breast cancer stem-like cell traits of TNBC cells in vitro and dramatically decreases tumorigenic frequency and lung metastasis in vivo.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Full Article

    Atypical Induction of HIF-1α Expression by Pericellular Notch1 Signaling Suffices for the Malignancy of Glioblastoma Multiforme Cells

    The expression of HIF-1α was significantly elevated in highly dense glioblastoma cells, even under non-hypoxic conditions. Atypical HIF-1α expression was associated with the Notch1 signaling pathway in both glioblastoma and glioblastoma stem cells.
    [Cellular and Molecular Life Sciences]

    Full Article

    Loss of SNAI1 Induces Cellular Plasticity in Invasive Triple-Negative Breast Cancer Cells

    SNAI1 knockout cells exhibited plasticity in differentiation, drifting towards the luminal phenotype, gained stemness potential, and could differentiate into acinar mammospheres in 3D culture.
    [Cell Death & Disease]

    Full Article

    Mechanism of RIP2 Enhancing Stemness of Glioma Cells Induces Temozolomide Resistance.

    Cancer stemness of glioma cells was investigated by sphere formation assays, clone formation assays, and xenograft tumor formation assays. The expression of RIP2, p-NF-κB, IκBα, CD133, or SOX-2 was detected by Western blotting and immunofluorescence.
    [CNS Neuroscience & Therapeutics]

    Full Article

    Folic Acid Depletion As Well as Oversupplementation Helps in the Progression of Hepatocarcinogenesis in HepG2 Cells

    HepG2 cells were administered with three different concentrations of folic acid for 10 days. Fluorescence-activated cell sorting was done to evaluate cell viability and apoptosis. Agarose-coated plates were used to access cancer stem cells number.
    [Scientific Reports]

    Full Article

    Radiotherapy-Induced Oxidative Stress and Fibrosis in Breast Cancer Are Suppressed by Vactosertib, a Novel, Orally Bioavailable TGF-β/ALK5 Inhibitor

    Researchers used a 4T1-Luc allograft BALB/c syngeneic mouse model and 4T1-Luc and MDA-MB-231 cells for histological analysis, qRT-PCR, western blotting, reactive oxygen species analysis, mammosphere formation analysis, and monolayer fluorescence imaging analysis.
    [Scientific Reports]

    Full Article

    Thioridazine Combined with Carboplatin Results in Synergistic Inhibition of Triple Negative Breast Cancer by Targeting Cancer Stem Cells

    Thioridazine demonstrated the capability of destroying breast cancer stem cells and this effect was amplified when combined with carboplatin treatment.
    [Translational Oncology]

    Full Article

    Establishment and Characterization of Chemotherapy-Enriched Sphere-Forming Cells With Stemness Phenotypes as a New Cell Line (BAG50) of Gastric Carcinoma

    Investigators reported establishing a novel cell line, BAG50, with stemness properties. Chemotherapy-enriched sphere-forming cells with CSC properties isolated from a patient with gastric cancer were cultured in a serum-containing medium and passaged for up to 51 passages.
    [Medical Oncology]

    Full Article
    Five tips for returning to the lab after time off
    REVIEWS

    Cancer Fitness Genes: Emerging Therapeutic Targets for Metastasis

    Since normal cells do not experience high levels of stress under physiological conditions, targeting cancer fitness genes is less likely to cause toxicity to noncancerous tissues. Therefore, investigators summarize the key features and function of cancer fitness genes and discuss their therapeutic potential.
    [Trends in Cancer]

    Abstract

    Targeting Cancer Stem Cells with Polymer Nanoparticles for Gastrointestinal Cancer Treatment

    The authors summarize the characteristics of gastrointestinal CSCs and review the latest research in treating gastrointestinal malignant tumors using polymer nanoparticles to target cancer stem cells.
    [Stem Cell Research & Therapy]

    Full Article
    INDUSTRY AND POLICY NEWS

    Abcuro Initiates Phase I/II Trial Evaluating ABC008 in Patients with T Cell Large Granular Lymphocytic Leukemia

    Abcuro, Inc. announced initiation of a Phase I/II dose escalation trial to evaluate the safety, tolerability, and proof-of-concept of ABC008 in patients with T cell large granular lymphocytic leukemia who suffer from anemia and/or neutropenia.
    [Abcuro, Inc.]

    Press Release

    Cue Biopharma Granted FDA Fast Track Designation for CUE-101 for the Treatment of Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma

    Cue Biopharma, Inc. announced that the FDA has granted Fast Track designation to CUE-101 for the treatment of patients with human papilloma virus recurrent/metastatic head and neck squamous cell carcinoma as a monotherapy and in combination with pembrolizumab.
    [Cue Biopharma, Inc.]

    Press Release
    FEATURED EVENT

    Cell Symposia: Multifaceted Mitochondria

    November 6 – 8, 2022
    Seville, Spain

    > See All Events

    JOB OPPORTUNITIES

    Assistant Professor – Biochemistry and Molecular Genetics

    University of Illinois Chicago – Chicago, Illinois, United States

    Postdoctoral Associate – Hematopoietic Stem Cells

    Baylor College of Medicine – Houston, Texas, United States

    Postdoctoral Researcher – Bioinformatics, mRNA Translation in Cancer

    Netherlands Cancer Institute (AVL) – Amsterdam, Netherlands

    Postdoctoral Research Scientist – Epithelial Plasticity and Virulence in Lung Adenocarcinoma

    CRUK Beatson Institute for Cancer Research – Glasgow, United Kingdom

    Postdoctoral Researcher – Cancer and Stem Cell Biology

    Stanford Medicine – Stanford, California, United States

    > See All Jobs

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