| Vol. 11.37 – 12 October, 2022 |
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| Scientists examined genome-wide somatic mutation patterns in 42 healthy adult stem cells (ASCs) of the colon or the liver from 14 cancer patients that received systemic chemotherapy and/or local radiotherapy. [Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators addressed the role of adhesion protein integrin α2, which was identified in a high-throughput screen for novel potential targets in glioblastoma cells treated with standard therapy consisting of temozolomide and radiation. [Neuro-Oncology] |
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| Researchers showed that asymmetric Numb partitioning per se is insufficient for the proper control of mammary stem cell dynamics, with differential phosphorylation and functional inactivation of Numb in the two progeny also required. [Journal of Cell Biology] |
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| Scientists identified novel immunogenic peptide epitopes derived from CSC-associated Sox2 and Nanog, and synthesized synthetic high-density lipoprotein nanodisc vaccine formulated with Sox2, Nanog, and aldehyde dehydrogenase antigen peptides together with CpG, a Toll-like receptor 9 agonist. [Journal of Controlled Release] |
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| Investigators validated significant overexpression of PLA2G2A across in situ gallbladder carcinoma (GBC) cells, together with increased proliferation and cancer stemness in PLA2G2A-overexpressing GBC cells, indicating an important role for PLA2G2A during early carcinogenesis. [Cell Discovery] |
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| Scientists identified the zinc finger transcription factor 148 (ZNF148) as a direct target of the MYC proto-oncogene (MYC). ZNF148 suppressed cell proliferation and migration and was transcriptionally repressed by MYC in breast cancer. [Oncogenesis] |
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| Researchers found that TNF-like weak inducer of apoptosis (TWEAK) and its receptor, Fn14, were strong inducers of alternative NF-κB signaling, and were enriched in ovarian tumors after chemotherapy treatment. TWEAK in combination with chemotherapy induced expression of the CSC marker CD117 in CD117- cells. [Molecular Cancer Research] |
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| Several putative cytotoxic compounds were evaluated for their cytotoxic effects on glioma stem cells, cancer cell lines, and immortalized cells using a variety of methods to study cell proliferation, cell death, DNA damage, mitochondrial membrane changes, and tumor formation in vitro. [Phytomedicine] |
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| Human hepatocellular carinoma (HCC) cohort analysis indicated that the epigenetic regulator polycomb chromobox homologue 4 (CBX4) was overexpressed in human HCC. Scientists found that CBX4 expression was significantly higher in CD44+ CD133+Hep3B CSCs. [Biological Chemistry] |
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| To identify candidate compounds targeting CSCs, investigators established a new screening strategy with colorectal CSC spheres and non-CSC spheres in a 3D culture system. They identified polyether cation ionophores that selectively inhibited CSC sphere formation. [Journal of Antibiotics] |
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| The authors review the most common acute chemotherapy-associated adverse events (CAAEs) having a major effect on survival, quality of life, function and/or continuation of optimal therapy, and summarize the underlying pathophysiology. [Nature Reviews Clinical Oncology] |
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| Investigators summarise the role of RHAMM in normal brain development and the adult brain, focusing on the neural stem and progenitor cells, and discuss the current knowledge on RHAMM involvement in glioblastoma progression. [British Journal of Cancer] |
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| This review highlights the critical roles of the microenvironmental cues that regulate CSC function and endow them with drug resistance properties, and also explores the latest advancement and challenges in biomaterial-based scaffold structure for therapeutic approaches against CSC chemoresistance. [ACS Biomaterials Science & Engineering] |
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| Tampa General Hospital Cancer Institute established an adult Bone Marrow Transplant and Cell Therapies unit that focused on treating patients with aggressive blood cancers such as leukemias, lymphomas, multiple myeloma as well as other cancers. [Tampa General Hospital] |
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| November 7 – 8, 2022 London, England, United Kingdom |
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| Memorial Sloan Kettering Cancer Center – New York City, New York, United States |
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| University of Illinois Chicago – Chicago, Illinois, United States |
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| Netherlands Cancer Institute (AVL) – Amsterdam, Netherlands |
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| CRUK Beatson Institute for Cancer Research – Glasgow, United Kingdom |
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| Baylor College of Medicine – Houston, Texas, United States |
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