Cancer Stem Cell News Volume 11.38 | Oct 19 2022


    2022-10-19 | CSCN 11.38

    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 11.38 – 19 October, 2022

    Glioblastoma Stem Cell-Specific Histamine Secretion Drives Pro-Angiogenic Tumor Microenvironment Remodeling

    Scientists interrogated metabolites that were preferentially secreted from glioma stem cells (GSCs) and found that GSCs produced and secreted histamine to shape a pro-angiogenic tumor microenvironment.
    [Cell Stem Cell]

    Full ArticleGraphical Abstract
    How have LSCs changed our understanding of myeloid malignancies? Webinar by Dr. Christopher Park, NYU
    PUBLICATIONSRanked by the impact factor of the journal

    P300 Promotes Tumor Recurrence by Regulating Radiation-Induced Conversion of Glioma Stem Cells to Vascular-Like Cells

    Scientists employed single-cell and whole transcriptomic analyses to uncover that radiation induced a dynamic shift in functional states of glioma cells, allowing for acquisition of vascular endothelial-like and pericyte-like cell phenotypes.
    [Nature Communications]

    Full Article

    HSF1 Is a Driver of Leukemia Stem Cell Self-Renewal in Acute Myeloid Leukemia

    Deletion of Hsf1 dysregulated multifaceted genes involved in leukemic stem cell stemness and suppressed mitochondrial oxidative phosphorylation through downregulation of succinate dehydrogenase C, a direct HSF1 target.
    [Nature Communications]

    Full Article

    TrkC-Mediated Inhibition of DJ-1 Degradation Is Essential for Direct Regulation of Pathogenesis of Hepatocellular Carcinoma

    Researchers demonstrated the possible association between upregulation of TrkC and acquisition of CSC traits or chemoresistance in hepatocellular carcinoma (HCC). They showed that upregulation of TrkC was closely associated with the survival and progression of HCC in vivo and in vitro.
    [Cell Death & Disease]

    Full Article

    MiR-378a-3p Acts as a Tumor Suppressor in Gastric Cancer via Directly Targeting RAB31 and Inhibiting the Hedgehog Pathway Proteins GLI1/2

    Tumorsphere formation assays were performed to assess the stemness of gastric CSCs, revealing that miR-378a-3p inhibited GLI1/2 in the Hedgehog signaling pathway and attenuated the stemness of gastric CSCs.
    [Cancer Biology & Medicine]

    AbstractFull Article

    MCM2 Promotes the Stemness and Sorafenib Resistance of Hepatocellular Carcinoma Cells via Hippo Signaling

    Stemness-related molecules and phenotypes were examined to evaluate the impact of MCM2 on stemness. The expression levels of key molecules of the hippo signaling pathway together with downstream target genes were examined to evaluate the effect of MCM2 on hippo signaling.
    [Cell Death Discovery]

    Full Article

    Systematic Molecular Profiling of Acute Leukemia Cancer Stem Cells Allows Identification of Druggable Targets

    Investigators developed a novel computational pipeline to analyze the transcriptomic profiles of acute myeloid leukemia (AML) CSCs, and identify novel candidate AML CSC markers and drug targets. They applied a top-down meta-analysis strategy, integrating The Cancer Genome Atlas data with CSC datasets.

    AbstractFull Article

    NDR1 Activates CD47 Transcription by Increasing Protein Stability and Nuclear Location of ASCL1 to Enhance Cancer Stem Cell Properties and Evasion of Phagocytosis in Small Cell Lung Cancer

    The authors explored the function of NDR1 in the control of CSC properties in small cell lung cancer (SCLC), and found that NDR1 promoted ASCL1 expression to enhance NDR1-promoted CSC properties and evasion of phagocytosis in SCLC cells.
    [Medical Oncology]


    Epigenetic Regulation of RARB Overcomes the Radio-Resistance of Colorectal Carcinoma Cells via Cancer Stem Cells

    Scientists investigated how retinoic acid receptor beta (RARB) affected the biological characteristics of CSCs and radio-resistance in colorectal carcinoma and the epigenetic mechanism.
    [Journal of Radiation Research]

    Full Article
    Be sure the cells you’re gene editing are still HSPCs with StemSpan™ SFEM II culture medium.

    Artificial Intelligence for Multimodal Data Integration in Oncology

    The authors present a synopsis of AI methods and strategies for multimodal data fusion and association discovery, outlining approaches for AI interpretability and directions for AI-driven exploration through multimodal data interconnections.
    [Cancer Cell]

    Full ArticleGraphical Abstract

    Regulation of the Aryl Hydrocarbon Receptor in Cancer and Cancer Stem Cells of Gynecological Malignancies: An Update on Signaling Pathways

    Investigators explore the molecular mechanisms regulating the crosstalk and interaction of transcription factor AhR with cancer-related signaling pathways, such as apoptosis, epithelial-mesenchymal transition, immune checkpoints, and G-protein-coupled receptors in gynecological malignancies.
    [Seminars in Cancer Biology]

    AbstractFull Article

    Sierra Space and UCSD Collaborate for a Space Station Researching Stem Cells

    UC San Diego and Sierra Space have established an agreement to jointly develop the world’s first commercially owned and operated space station, Orbital Reef.
    [UCSD Guardian]

    Press Release

    Frontiers in Cancer Science 2022

    November 7 – 9, 2022
    Singapore, Singapore

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    Postdoctoral Researchers – Computational Biology

    Beth Israel Deaconess Medical Center – Boston, MA, United States

    Manager – Laboratory Services

    STEMCELL Technologies – Vancouver, British Columbia, Canada

    Associate Professor – Skin Cancer

    University College Dublin – Dublin, Ireland

    Advanced Research Assistant – Artificial Intelligence in Cancer Evolution and Genomics

    German Cancer Research Center in the Helmholtz Association – Heidelberg, Germany

    Postdoctoral Researcher – Developmental Biology

    Memorial Sloan Kettering Cancer Center – New York City, New York, United States

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