 | | Vol. 11.38 – 19 October, 2022 |
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| Scientists interrogated metabolites that were preferentially secreted from glioma stem cells (GSCs) and found that GSCs produced and secreted histamine to shape a pro-angiogenic tumor microenvironment.
[Cell Stem Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists employed single-cell and whole transcriptomic analyses to uncover that radiation induced a dynamic shift in functional states of glioma cells, allowing for acquisition of vascular endothelial-like and pericyte-like cell phenotypes.
[Nature Communications] |
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| Deletion of Hsf1 dysregulated multifaceted genes involved in leukemic stem cell stemness and suppressed mitochondrial oxidative phosphorylation through downregulation of succinate dehydrogenase C, a direct HSF1 target.
[Nature Communications] |
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| Researchers demonstrated the possible association between upregulation of TrkC and acquisition of CSC traits or chemoresistance in hepatocellular carcinoma (HCC). They showed that upregulation of TrkC was closely associated with the survival and progression of HCC in vivo and in vitro.
[Cell Death & Disease] |
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| Tumorsphere formation assays were performed to assess the stemness of gastric CSCs, revealing that miR-378a-3p inhibited GLI1/2 in the Hedgehog signaling pathway and attenuated the stemness of gastric CSCs.
[Cancer Biology & Medicine] |
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| Stemness-related molecules and phenotypes were examined to evaluate the impact of MCM2 on stemness. The expression levels of key molecules of the hippo signaling pathway together with downstream target genes were examined to evaluate the effect of MCM2 on hippo signaling.
[Cell Death Discovery] |
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| | Investigators developed a novel computational pipeline to analyze the transcriptomic profiles of acute myeloid leukemia (AML) CSCs, and identify novel candidate AML CSC markers and drug targets. They applied a top-down meta-analysis strategy, integrating The Cancer Genome Atlas data with CSC datasets. |
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| The authors explored the function of NDR1 in the control of CSC properties in small cell lung cancer (SCLC), and found that NDR1 promoted ASCL1 expression to enhance NDR1-promoted CSC properties and evasion of phagocytosis in SCLC cells.
[Medical Oncology] |
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| Scientists investigated how retinoic acid receptor beta (RARB) affected the biological characteristics of CSCs and radio-resistance in colorectal carcinoma and the epigenetic mechanism.
[Journal of Radiation Research] |
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| The authors present a synopsis of AI methods and strategies for multimodal data fusion and association discovery, outlining approaches for AI interpretability and directions for AI-driven exploration through multimodal data interconnections.
[Cancer Cell] |
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| Investigators explore the molecular mechanisms regulating the crosstalk and interaction of transcription factor AhR with cancer-related signaling pathways, such as apoptosis, epithelial-mesenchymal transition, immune checkpoints, and G-protein-coupled receptors in gynecological malignancies.
[Seminars in Cancer Biology] |
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| UC San Diego and Sierra Space have established an agreement to jointly develop the world’s first commercially owned and operated space station, Orbital Reef.
[UCSD Guardian] |
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| November 7 – 9, 2022
Singapore, Singapore |
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| | Beth Israel Deaconess Medical Center – Boston, MA, United States |
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| | STEMCELL Technologies – Vancouver, British Columbia, Canada |
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| | University College Dublin – Dublin, Ireland |
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| | German Cancer Research Center in the Helmholtz Association – Heidelberg, Germany |
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| | Memorial Sloan Kettering Cancer Center – New York City, New York, United States |
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Cancer Stem Cell News
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