 | | Vol. 11.43 – 23 November, 2022 |
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| Researchers interrogated super-enhancer landscapes of primary glioblastoma specimens and patient-derived glioma stem cells, revealing a kelch domain-containing gene (KLHDC8A) with a previously unknown function as an epigenetically-driven oncogene.
[Journal of Clinical Investigation] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists revealed that the metabolic niche component, ATP, efficiently induced ion influx in leukemia-initiating cells through its ligand-gated ion channel, P2X1.
[Leukemia] |
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| The authors identified hypermitophagy as a feature of human lung CSCs, promoting metabolic adaption via the Notch1-AMPK axis to drive CSC expansion.
[EMBO Reports] |
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| TINCR was found to be highly expressed in hepatocellular carcinoma tissues and liver CSCs (LCSCs). In vitro and in vivo assays for the first time showed that TINCR was required for LCSC self-renewal and tumorigenesis.
[Cell Death & Disease] |
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| Investigators found that during the process of dormancy and reactivation induced by cisplatin, non-small cell lung cancer cells underwent sequential epithelial-to-mesenchymal transition-mesenchymal-to-epithelial transition with enrichment of CSCs.
[Cell Death & Disease] |
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| In order to develop potent and selective CYP4Z1 inhibitors, a series of novel N-hydroxyphenylformamidines were rationally designed and synthesized from a pan-CYP inhibitor HET0016.
[Journal of Medicinal Chemistry] |
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| Researchers investigated whether metformin could revert F. nucleatum-induced chemoresistance and explored the mechanism.
[British Journal of Cancer] |
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| Investigators tested whether ligand-independent activation of EphA2 modulated chemoresistance by enhancing stemness in small-cell lung cancer.
[Cancer Science] |
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| Scientists found that PTEN overexpression and nuclear β-catenin stabilization promoted the establishment and maintenance of morular phenotype associated with epithelial–mesenchymal transition/CSC-like features in endometrial carcinoma cells.
[Cell Communication and Signaling] |
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| The authors describe new techniques that allow access to a range of tissue and cancer types, novel fluorescent reporters and biosensors that allow fate mapping and the probing of functional and phenotypic states, and the clinical applications that have arisen.
[Nature Reviews Cancer] |
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| Investigators provide insight into the relationship between diabetes and pancreatic cancer and the methods that can be employed to diagnose this disease at an earlier stage successfully.
[Life Sciences] |
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| A University of Cincinnati (UC) Clermont professor has received a $100,000 PhRMA Foundation Faculty Starter Grant in drug discovery for her work on new antibiotics capable of taking on CSCs.
[University of Cincinnati] |
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| December 7 – 9, 2022
Geneva, Switzerland |
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| | City of Hope – Los Angeles, California, United States |
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| | University of Miami – Miami, Florida, United States |
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| | Icahn School of Medicine at Mount Sinai – New York City, New York, United States |
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| | AstraZeneca – Waltham, Massachusetts, United States |
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| | STEMCELL Technologies, Inc. – Boston, Massachusetts, United States |
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
