Cancer Stem Cell News Volume 11.43 | Nov 24 2022

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    2022-11-23 | CTN 11.43


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 11.43 – 23 November, 2022
    TOP STORY

    Superenhancer-Activation of KLHDC8A Drives Glioma Ciliation and Hedgehog Signaling

    Researchers interrogated super-enhancer landscapes of primary glioblastoma specimens and patient-derived glioma stem cells, revealing a kelch domain-containing gene (KLHDC8A) with a previously unknown function as an epigenetically-driven oncogene.
    [Journal of Clinical Investigation]

    AbstractGraphical Abstract
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    P2X1 Enhances Leukemogenesis through PBX3-BCAT1 Pathways

    Scientists revealed that the metabolic niche component, ATP, efficiently induced ion influx in leukemia-initiating cells through its ligand-gated ion channel, P2X1.
    [Leukemia]

    Full Article

    Mitophagy Bridges DNA Sensing with Metabolic Adaption to Expand Lung Cancer Stem-Like Cells

    The authors identified hypermitophagy as a feature of human lung CSCs, promoting metabolic adaption via the Notch1-AMPK axis to drive CSC expansion.
    [EMBO Reports]

    AbstractGraphical Abstract

    The Long Noncoding RNA TINCR Promotes Self-Renewal of Human Liver Cancer Stem Cells through Autophagy Activation

    TINCR was found to be highly expressed in hepatocellular carcinoma tissues and liver CSCs (LCSCs). In vitro and in vivo assays for the first time showed that TINCR was required for LCSC self-renewal and tumorigenesis.
    [Cell Death & Disease]

    Full Article

    Cell-Cell Contact-Driven EphB1 Cis- and Trans- Signalings Regulate Cancer Stem Cells Enrichment after Chemotherapy

    Investigators found that during the process of dormancy and reactivation induced by cisplatin, non-small cell lung cancer cells underwent sequential epithelial-to-mesenchymal transition-mesenchymal-to-epithelial transition with enrichment of CSCs.
    [Cell Death & Disease]

    Full Article

    Identification of a Novel Potent CYP4Z1 Inhibitor Attenuating the Stemness of Breast Cancer Cells Through Lead Optimization

    In order to develop potent and selective CYP4Z1 inhibitors, a series of novel N-hydroxyphenylformamidines were rationally designed and synthesized from a pan-CYP inhibitor HET0016.
    [Journal of Medicinal Chemistry]

    AbstractGraphical Abstract

    Metformin Abrogates Fusobacterium nucleatum-Induced Chemoresistance in Colorectal Cancer by Inhibiting miR-361-5p/Sonic Hedgehog Signaling-Regulated Stemness

    Researchers investigated whether metformin could revert F. nucleatum-induced chemoresistance and explored the mechanism.
    [British Journal of Cancer]

    Full Article

    Ligand-Independent EphA2 Contributes to Chemoresistance in Small-Cell Lung Cancer by Enhancing PRMT1-Mediated SOX2 Methylation

    Investigators tested whether ligand-independent activation of EphA2 modulated chemoresistance by enhancing stemness in small-cell lung cancer.
    [Cancer Science]

    Abstract

    PTEN Overexpression and Nuclear β-Catenin Stabilization Promote Morular Differentiation through Induction of Epithelial–Mesenchymal Transition and Cancer Stem Cell-Like Properties in Endometrial Carcinoma

    Scientists found that PTEN overexpression and nuclear β-catenin stabilization promoted the establishment and maintenance of morular phenotype associated with epithelial–mesenchymal transition/CSC-like features in endometrial carcinoma cells.
    [Cell Communication and Signaling]

    Full Article
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    REVIEWS

    Intravital Imaging To Study Cancer Progression and Metastasis

    The authors describe new techniques that allow access to a range of tissue and cancer types, novel fluorescent reporters and biosensors that allow fate mapping and the probing of functional and phenotypic states, and the clinical applications that have arisen.
    [Nature Reviews Cancer]

    Abstract

    Implications of Cancer Stem Cells in Diabetes and Pancreatic Cancer

    Investigators provide insight into the relationship between diabetes and pancreatic cancer and the methods that can be employed to diagnose this disease at an earlier stage successfully.
    [Life Sciences]

    Abstract
    INDUSTRY AND POLICY NEWS

    UC Clermont Professor Receives $100,000 Grant for Cancer Research

    A University of Cincinnati (UC) Clermont professor has received a $100,000 PhRMA Foundation Faculty Starter Grant in drug discovery for her work on new antibiotics capable of taking on CSCs.
    [University of Cincinnati]

    Press Release
    FEATURED EVENT

    ESMO Immuno-Oncology Congress 2022

    December 7 – 9, 2022
    Geneva, Switzerland

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Cancer/Stem Cell Biology

    City of Hope – Los Angeles, California, United States

    Postdoctoral Associate – Breast Cancer Tumor Immunology

    University of Miami – Miami, Florida, United States

    Postdoctoral Positions – Cancer/Leukemia Stem Cells

    Icahn School of Medicine at Mount Sinai – New York City, New York, United States

    Scientist – Hematological Cancers, Oncology Bioscience

    AstraZeneca – Waltham, Massachusetts, United States

    Senior Program Associate – Science in the City

    STEMCELL Technologies, Inc. – Boston, Massachusetts, United States

    > See All Jobs

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