Cancer Stem Cell News Volume 11.44 | Dec 7 2022

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    2022-12-07 | CSCN 11.44


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 11.44 – 7 December, 2022
    TOP STORY

    Interferon-Dependent SLC14A1+ Cancer-Associated Fibroblasts Promote Cancer Stemness via WNT5A in Bladder Cancer

    A population of cancer-associated fibroblasts was induced by interferon signaling and conferred stemness to bladder cancer cells via the WNT5A paracrine pathway.
    [Cancer Cell]

    AbstractGraphical Abstract
    New human primary cancer-sourced blood products, immune cell subsets, and more. Click to view products.
    PUBLICATIONSRanked by the impact factor of the journal

    The Insulin and IGF Signaling Pathway Sustains Breast Cancer Stem Cells by IRS2/PI3K-Mediated Regulation of MYC

    Researchers reported that insulin/insulin-like growth factor (IGF) signaling supported breast CSC self-renewal in an IRS2-phosphatidylinositol 3-kinase (PI3K)-dependent manner that involved the activation and stabilization of MYC.
    [Cell Reports]

    Full ArticleGraphical Abstract

    NRP1 Inhibition Modulates Radiosensitivity of Medulloblastoma by Targeting Cancer Stem Cells

    Neuropilin-1 receptor (NRP1) inhibition with a novel peptidomimetic agent, MR438, was evaluated with radiotherapy in medulloblastoma models in vitro on cancer stem-like cells as well as in vivo on heterotopic and orthotopic xenografts.
    [Cancer Cell International]

    Abstract

    RhoC in Association With TET2/WDR5 Regulates Cancer Stem Cells by Epigenetically Modifying the Expression of Pluripotency Genes

    Cell lines and clinical specimen-based findings demonstrated that RhoC regulated tumor phenotypes such as clonogenicity and anoikis resistance.
    [Cellular and Molecular Life Sciences]

    Abstract

    Heterogeneous Matrix Stiffness Regulates the Cancer Stem-Like Cell Phenotype in Hepatocellular Carcinoma

    Researchers provided new insights into the interaction between matrix stiffness, cancer cell stemness, and heterogeneity, while also providing a novel hepatocellular carcinoma therapeutic strategy.
    [Journal of Translational Medicine]

    Full Article

    CD14, a Novel Surface Marker of Esophageal Cancer Stem Cells

    Investigators utilized paraffin‑embedded sections of human esophageal carcinoma and indicated that the ALDH1‑labeled esophageal CSCs expressed CD14 and primary CD14+ cells possessed the characteristics of CSCs.
    [Oncology Reports]

    Abstract

    Long Non-Coding RNA TDRG1 Aggravates Lung Cancer Stemness by Binding to Sox2 mRNA

    Scientists collected 3D non-adherent spheres as the CSC model to measure lncRNA TDRG1 level in lung CSC and the parental lung cancer cells, and found that TDRG1 level was significantly upregulated in lung CSCs compared to that of parental lung cancer cells
    [Environmental Toxicology]

    Abstract

    Gastric Cancer Stem Cell-Derived Exosomes Promoted Tobacco Smoke-Triggered Development of Gastric Cancer by Inducing the Expression of circ670

    Researchers provided a new insight into tobacco smoke promoting the progression of gastric cancer, demonstrating that tobacco smoke-induced exosomes promoted the spheroidizing ability, stemness genes expression, and epithelial-mesenchymal transition process of gastric cancer stem cells.
    [Medical Oncology]

    Abstract

    High Percentage of Cancer Stem Cells in Metastatic Locations: Upregulation of cicBIRC6 in Highly Metastatic Breast Cancer Subline

    In breast cancer, metastatic tumor cells have higher stem cell properties, therefore the authors evaluated the expression of cicBIRC6 in these cells.
    [Molecular Biology Reports]

    Abstract

    Cyanidin Inhibits Glioma Stem Cells Proliferation through the Wnt Signaling Pathway

    Cyanidin significantly reduced the cell viability of all glioma stem cells, and exhibited the most substantial effect in GBM2 but no apparent effect in 293T cells.
    [International Journal of Neuroscience]

    Abstract
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    REVIEWS

    Metabolic Determinants of Tumor Initiation

    The authors discuss how cell-intrinsic factors, such as the cell of origin or transforming oncogene, and cell-extrinsic factors, such as local nutrient availability, promote or restrain tumour initiation.
    [Nature Reviews Endocrinology]

    Abstract

    The Vulnerable Primed Cancer Stem Cells in Disguise: Demystifying the Role of Maspin

    In light of the recently established characterization of primed stem cells in development, scientists propose that CSCs also need to undergo priming before their transition to various progeny phenotypes.
    [Cancer and Metastasis Reviews]

    Full Article

    Targeting Redox Regulation and Autophagy Systems in Cancer Stem Cells

    Investigators highlight the molecular mechanisms useful for expanding therapeutic strategies based on modulating redox regulation and autophagy activation to targets.
    [Clinical and Experimental Medicine]

    Abstract
    INDUSTRY AND POLICY NEWS

    Personalis and UCSF to Study Clinical Utility of ctDNA for Treatment Response in Colorectal Cancer

    Personalis, Inc. announced a collaboration with UC San Francisco (UCSF) that will deploy a personalized liquid biopsy-based research use-only assay for a study of patients with colorectal cancer.
    [Personalis, Inc.]

    Press Release
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