Cancer Stem Cell News Volume 12.04 | Feb 1 2023

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    2023-02-01 | CSCN 12.04


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 12.04 – 1 February, 2023
    TOP STORY

    Immune Checkpoint HLA-E:CD94-NKG2A Mediates Evasion of Circulating Tumor Cells from NK Cell Surveillance

    Researchers characterized the transcriptomes of human pancreatic ductal adenocarcinoma circulating tumor cells, primary, and metastatic lesions at a single-cell scale.
    [Cancer Cell]

    AbstractGraphical Abstract
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    PUBLICATIONSRanked by the impact factor of the journal

    Targeting GSTP1 as Therapeutic Strategy against Lung Adenocarcinoma Stemness and Resistance to Tyrosine Kinase Inhibitors

    Investigators unveiled that Glutathione S-transferase pi (GSTP1) was upregulated in lung CSCs and supports tumor self-renewal, metastasis, and resistance to targeted tyrosine kinase inhibitors of lung adenocarcinoma both in vitro and in vivo.
    [Advanced Science]

    Full Article

    Mutated Axon Guidance Gene PLXNB2 Sustains Growth and Invasiveness of Stem Cells Isolated from Cancers of Unknown Primary

    Scientists found that a novel activating mutation of the axon guidance gene PLXNB2 sustained proliferative autonomy and confered invasive properties to stem cells isolated from cancers of unknown primary.
    [Embo Molecular Medicine]

    Full ArticleGraphical Abstract

    HERC2 Promotes Inflammation-Driven Cancer Stemness and Immune Evasion in Hepatocellular Carcinoma by Activating STAT3 Pathway

    Researchers sought to identify the new target that was involved in inflammation-related liver tumorigenesis.
    [Journal of Experimental & Clinical Cancer Research]

    Full Article

    A Clinically Feasible Circulating Tumor Cell Sorting System for Monitoring the Progression of Advanced Hepatocellular Carcinoma

    Epithelial cell adhesion molecule/vimentin/Glypican-3 antibody-modified lipid magnetic spheres were used to capture tumor cells with epithelial phenotype in order to capture more circulating tumor cells with a more comprehensive phenotype for monitoring tumor metastasis.
    [Journal of Nanobiotechnology]

    Full Article

    Tumor Stemness Score to Estimate Epithelial-to-Mesenchymal Transition (EMT) and Cancer Stem Cells (CSCs) Characterization and to Predict the Prognosis and Immunotherapy Response in Bladder Urothelial Carcinoma

    Investigators explored biomarkers of tumor stemness (TS) by single-cell sequencing analysis. Subtypes of bladder urothelial carcinoma were identified using clustering analysis based on TS biomarkers.
    [Stem Cell Research & Therapy]

    Full Article

    Enhancer Remodeling Drives MLL Oncogene-Dependent Transcriptional Dysregulation in Leukemia Stem Cells

    The authors delineated the active enhancer landscape and observed pervasive enhancer malfunction in leukemia stem cells.
    [Blood Advances]

    Abstract

    Extracellular Vesicles Secreted by Triple Negative Breast Cancer Stem Cells Trigger Pre-Metastatic Niche Remodeling and Metastatic Growth in the Lungs

    Researchers selectively isolated and characterized extracellular vesicles from CSC or differentiated cancer cells from the MDA-MB-231 triple negative breast cancer cell line.
    [International Journal of Cancer]

    Abstract

    Compound Nanoemulsion Combined with Differentiation/Cytotoxicity Drugs for Modulating Breast Cancer Stemness

    In vivo antitumor efficacy showed that the compound nanoemulsion could reduce the proportion of breast cancer stem cells to 1.18% by inhibiting the expression of Pin1.
    [Molecular Pharmaceutics]

    AbstractGraphical Abstract

    Novel Terpestacin Derivatives with L-amino Acid Residue as Anticancer Agents against U87MG-Derived Glioblastoma Stem Cells

    Investigators evaluated the anticancer activities of 17 novel terpestacin derivatives against U87MG-derived glioblastoma stem cells.
    [Bioorganic Chemistry]

    Full ArticleGraphical Abstract
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    REVIEWS

    Leukemic Stem Cells and Therapy Resistance in Acute Myeloid Leukemia

    The authors discuss leukemic stem cell (LSC) biology and associated resistance mechanisms, potential therapeutic LSC vulnerabilities and current clinical trial activities.
    [Haematologica]

    Full Article

    Cancer Stem Cells: Recent Insights and Therapies

    Scientists discuss the latest insights into the characteristics, markers, and mechanisms of CSCs and describe the crosstalk between CSCs and other cells in the tumor microenvironment.
    [Biochemical Pharmacology]

    Full ArticleGraphical Abstract
    INDUSTRY AND POLICY NEWS

    Stricter US Guidelines for ‘Gain-of-Function’ Research Are on the Way — Maybe

    A panel of experts joined a meeting of the US National Science Advisory Board of Biosecurity, discussing on issues such as how privately funded risky research would be regulated, the role of research institutions in identifying potentially dangerous research, and much more.
    [Nature]

    Press Release
    FEATURED EVENT

    Lund Stem Cell Center 20th Anniversary

    April 17 – 19, 2023
    Lund, Sweden

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    JOB OPPORTUNITIES

    Staff Scientist – Genetics and Epigenetics of Gastrointestinal Cancers

    Beckman Research Institute – Monrovia, California, United States

    PhD Student – Computational Oncology

    Essen University Hospital – Essen, Germany

    Postdoctoral Fellow – Cancer Biology

    University of Bergen – Bergen, Norway

    Faculty Position – Cancer Stem Cell Biology

    Michigan State University – East Lansing, Michigan, United States

    Directors of Clinical Research Programs – Cancer Biology

    IRCCS Candiolo Cancer Institute – Turin, Italy

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