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Vol. 12.05 – 8 February, 2023
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Researchers reported a new proton (H+) modulation approach to selectively eradicate CSCs via cutting off the H+ leaks on the inner mitochondrial membrane.
[Journal of the American Chemical Society]
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PUBLICATIONSRanked by the impact factor of the journal
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In glioblastoma CSCs, WDR5 inhibitors blocked WRAD complex assembly and reduced H3K4 trimethylation and expression of genes involved in CSC-relevant oncogenic pathways.
[Genes & Development]
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Investigators described a concise three-gene expression signature, leukemic stem cell-3, as an independent and robust prognostic factor for leukemia-free and overall survival in chronic myelomonocytic leukemia.
[British Journal Of Haematology]
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Scientists showed that the acute myeloid leukemia-specific autocrine loop constituted of T cell immunoglobulin mucin-3 (TIM-3) and its ligand, galectin-9, drove the canonical Wnt pathway to stimulate self-renewal and propagation of leukemic stem cells.
[Blood Advances]
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Circulating tumor cells were analyzed in patients with metastatic prostate cancer during radiotherapy with CellSearch, multi-color flow cytometry, and imaging cytometry.
[International Journal of Cancer]
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The authors studied the effects of low-dose human phthalate exposure on breast CSCs to explore its underlying mechanism as they remain largely unexplored.
[Ecotoxicology and Environmental Safety]
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Scientists established two radioresistant colorectal cancer (CRC) cell lines, HCT116-R and RKO-R, using fractionated irradiation to explore the role of CSCs in regulating resistance to radiotherapy in CRC.
[Cell Death Discovery]
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Researchers investigated the potential mechanism for transient EBV/LMP1 exposure‑mediated persistent peroxisome proliferator‑activated receptor‑γ coactivator‑1β (PGC1β) expression and subsequent tumorigenesis through modification of mitochondrial function.
[Oncology Reports]
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Investigators used genetic approaches to specifically label CSC-derived extracellular vesicles and to perform Sortase-mediated in vivo proximity labeling of CSC niche cells.
[PLOS One]
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Scientists revealed the contribution of SEC61 translocon subunit gamma (SEC61G) in promoting cisplatin-induced CSC properties of head and neck squamous cell carcinoma cells via promoting Ca2+-mediated autophagy.
[Journal of Dental Sciences]
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The authors focus on E3 ubiquitin ligases and their roles and mechanisms in regulating essential hallmarks of CSCs, such as self-renewal, invasion and metastasis, immune evasion, and more.
[Cellular Oncology]
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Former universities minister Michelle Donelan has been appointed head of the newly-created Department for Science, Innovation, and Technology in a mini-reshuffle.
[Nature]
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February 22 – 23, 2023
Boston, Massachusetts, United States
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Howard Hughes Medical Institute – Dallas, Texas, United States
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Virginia Commonwealth University – Richmond, Virginia, United States
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The International Institute of Molecular and Cell Biology – Warsaw, Poland
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Beckman Research Institute – Monrovia, California, United States
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Essen University Hospital – Essen, Germany
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