Cancer Stem Cell News Volume 12.05 | Feb 8 2023

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    2023-02-08 | CSCN 12.05


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 12.05 – 8 February, 2023
    TOP STORY

    Cutting Off H+ Leaks on the Inner Mitochondrial Membrane: A Proton Modulation Approach to Selectively Eradicate Cancer Stem Cells

    Researchers reported a new proton (H+) modulation approach to selectively eradicate CSCs via cutting off the H+ leaks on the inner mitochondrial membrane.
    [Journal of the American Chemical Society]

    AbstractGraphical Abstract
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    WDR5 Represents a Therapeutically Exploitable Target for Cancer Stem Cells in Glioblastoma

    In glioblastoma CSCs, WDR5 inhibitors blocked WRAD complex assembly and reduced H3K4 trimethylation and expression of genes involved in CSC-relevant oncogenic pathways.
    [Genes & Development]

    Abstract

    A Three-Gene Leukemic Stem Cell Signature Score Is Robustly Prognostic in Chronic Myelomonocytic Leukemia

    Investigators described a concise three-gene expression signature, leukemic stem cell-3, as an independent and robust prognostic factor for leukemia-free and overall survival in chronic myelomonocytic leukemia.
    [British Journal Of Haematology]

    Abstract

    TIM-3 Signaling Hijacks the Canonical Wnt/β-Catenin Pathway to Maintain Cancer Stemness in Acute Myeloid Leukemia

    Scientists showed that the acute myeloid leukemia-specific autocrine loop constituted of T cell immunoglobulin mucin-3 (TIM-3) and its ligand, galectin-9, drove the canonical Wnt pathway to stimulate self-renewal and propagation of leukemic stem cells.
    [Blood Advances]

    Abstract

    Dynamics of CXCR4 Positive Circulating Tumor Cells in Prostate Cancer Patients during Radiotherapy

    Circulating tumor cells were analyzed in patients with metastatic prostate cancer during radiotherapy with CellSearch, multi-color flow cytometry, and imaging cytometry.
    [International Journal of Cancer]

    Abstract

    Low-Dose Phthalates Promote Breast Cancer Stem Cell Properties via the Oncogene ΔNp63α and the Sonic Hedgehog Pathway

    The authors studied the effects of low-dose human phthalate exposure on breast CSCs to explore its underlying mechanism as they remain largely unexplored.
    [Ecotoxicology and Environmental Safety]

    Full Article

    MiR-7-5p/KLF4 Signaling Inhibits Stemness and Radioresistance in Colorectal Cancer

    Scientists established two radioresistant colorectal cancer (CRC) cell lines, HCT116-R and RKO-R, using fractionated irradiation to explore the role of CSCs in regulating resistance to radiotherapy in CRC.
    [Cell Death Discovery]

    Full Article

    LMP1 Mediates Tumorigenesis through Persistent Epigenetic Modifications and PGC1β Upregulation

    Researchers investigated the potential mechanism for transient EBV/LMP1 exposure‑mediated persistent peroxisome proliferator‑activated receptor‑γ coactivator‑1β (PGC1β) expression and subsequent tumorigenesis through modification of mitochondrial function.
    [Oncology Reports]

    Abstract

    Cancer Stem Cell-Derived Extracellular Vesicles Preferentially Target MHC-II–Macrophages and PD1+ T Cells in the Tumor Microenvironment

    Investigators used genetic approaches to specifically label CSC-derived extracellular vesicles and to perform Sortase-mediated in vivo proximity labeling of CSC niche cells.
    [PLOS One]

    Full Article

    SEC61 Translocon Subunit Gamma Enhances Low-Dose Cisplatin-Induced Cancer-Stem Cell Properties of Head and Neck Squamous Cell Carcinoma via Enhancing Ca2+-Mediated Autophagy

    Scientists revealed the contribution of SEC61 translocon subunit gamma (SEC61G) in promoting cisplatin-induced CSC properties of head and neck squamous cell carcinoma cells via promoting Ca2+-mediated autophagy.
    [Journal of Dental Sciences]

    Full Article
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    REVIEWS

    E3 Ubiquitin Ligases in Cancer Stem Cells: Key Regulators of Cancer Hallmarks and Novel Therapeutic Opportunities

    The authors focus on E3 ubiquitin ligases and their roles and mechanisms in regulating essential hallmarks of CSCs, such as self-renewal, invasion and metastasis, immune evasion, and more.
    [Cellular Oncology]

    Abstract
    INDUSTRY AND POLICY NEWS

    UK Government Announces New Science Department and Minister

    Former universities minister Michelle Donelan has been appointed head of the newly-created Department for Science, Innovation, and Technology in a mini-reshuffle.
    [Nature]

    Press Release
    FEATURED EVENT

    2nd Next Generation Kinase Inhibitors Summit

    February 22 – 23, 2023
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    JOB OPPORTUNITIES

    Research Technician – Flow Cytometry

    Howard Hughes Medical Institute – Dallas, Texas, United States

    Postdoctoral Research Fellow – Cancer Stem Cells

    Virginia Commonwealth University – Richmond, Virginia, United States

    Junior Group Leader – RNA and Cell Biology

    The International Institute of Molecular and Cell Biology – Warsaw, Poland

    Staff Scientist – Genetics and Epigenetics of Gastrointestinal Cancers

    Beckman Research Institute – Monrovia, California, United States

    PhD Student – Computational Oncology

    Essen University Hospital – Essen, Germany

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