| Vol. 12.06 – 15 February, 2023 |
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| Researchers reported that a tRNA-modifying methylthiotransferase CDKAL1 promoted CSC-factor SALL2 synthesis by assembling the eIF4F translation initiation complex. [Advanced Science] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators reported that cisplatin treatment led to the activation of higher mitophagy through regulating CLU levels in oral CSCs. Moreover, both the gain-of-function and loss-of-function of CLU indicated its mitophagy-specific role in clearing damaged mitochondria. [Autophagy] |
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| Scientists showed that CDK5RAP2 was highly expressed in oral squamous cell carcinoma and its expression correlated with clinical stage and lymph node metastasis of the disease. [Cell Death & Disease] |
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| The authors reported that PD-L1 regulates not only the epithelial–mesenchymal transition but also the stem-like transition in liver cancer cells. They observed high PD-L1 expression in CD133+ liver CSCs and CSC-enriched tumorspheres. [Cancer Science] |
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| Researchers reported that the haploinsufficient tumour suppressor ASPP2, could inhibit HCC growth and stemness characteristics by regulating the Warburg effect through the WNT/β-catenin pathway. [Journal Of Cellular And Molecular Medicine] |
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| Investigators examined a subset of cancer-associated fibroblasts with high podoplanin expression, which is correlated with tumor metastasis and poor survival in gastric cancer patients. [Molecular Carcinogenesis] |
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| Softening and stiffening tumor cells promoted and suppressed their self-renewal in vitro and tumor formation/growth in vivo, suggesting the regulatory role of cell mechanics in self-renewal and tumorigenicity. [Biophysical Journal] |
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| Scientists showed that CSCs maintain increased motility in diverse environments including on 2D elastic polyacrylamide gels of various stiffness, 3D randomly oriented collagen matrices, and ectopic cerebral slices representative of a common metastatic site. [Biophysical Journal] |
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| Investigators developed a mouse model to mimic the late steps of the metastasis process using a tail-vein injection of esophageal CSCs. [Molecular Biology Reports] |
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| Scientists discuss modern approaches to epigenetic and gene regulation landscapes and the associated ideas of entropy and attractor states, illustrating how their definitions are both more precise and relevant to understanding cancer etiology and the plasticity of cancerous states. [Science] |
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| The International Society for Stem Cell Research (ISSCR) has announced that it will present this year’s ISSCR Momentum Award to Cédric Blanpain, M.D., Ph.D., professor and director of the laboratory of stem cells and cancer at the Université Libre de Bruxelles, Belgium. [International Society for Stem Cell Research] |
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| April 23 – 26, 2023 Paris, France |
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| The University of Melbourne – Melbourne, Australia |
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| Howard Hughes Medical Institute – Dallas, Texas, United States |
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| King’s College London – London, England, United Kingdom |
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| Virginia Commonwealth University – Richmond, Virginia, United States |
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| Vanderbilt-Ingram Cancer Center – Nashville, Tennessee, United States |
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