Cancer Stem Cell News Volume 12.06 | Feb 15 2023

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    2023-02-15 | CSCN 12.06


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 12.06 – 15 February, 2023
    TOP STORY

    CDKAL1 Drives the Maintenance of Cancer Stem-Like Cells by Assembling the eIF4F Translation Initiation Complex

    Researchers reported that a tRNA-modifying methylthiotransferase CDKAL1 promoted CSC-factor SALL2 synthesis by assembling the eIF4F translation initiation complex.
    [Advanced Science]

    Full Article
    New human primary cancer-sourced blood products, immune cell subsets, and more. Click to view products.
    PUBLICATIONSRanked by the impact factor of the journal

    CLU (Clusterin) Promotes Mitophagic Degradation of MSX2 through an AKT-DNM1L/Drp1 Axis to Maintain SOX2-Mediated Stemness in Oral Cancer Stem Cells

    Investigators reported that cisplatin treatment led to the activation of higher mitophagy through regulating CLU levels in oral CSCs. Moreover, both the gain-of-function and loss-of-function of CLU indicated its mitophagy-specific role in clearing damaged mitochondria.
    [Autophagy]

    Abstract

    CDK5RAP2 Is a Wnt Target Gene and Promotes Stemness and Progression of Oral Squamous Cell Carcinoma

    Scientists showed that CDK5RAP2 was highly expressed in oral squamous cell carcinoma and its expression correlated with clinical stage and lymph node metastasis of the disease.
    [Cell Death & Disease]

    Full Article

    PD-L1 Regulates Epithelial–Mesenchymal Transition and Cancer Stem Cell Phenotypes in Hepatocellular Carcinoma through SGK2/β-Catenin Signaling Pathway

    The authors reported that PD-L1 regulates not only the epithelial–mesenchymal transition but also the stem-like transition in liver cancer cells. They observed high PD-L1 expression in CD133+ liver CSCs and CSC-enriched tumorspheres.
    [Cancer Science]

    Abstract

    ASPP2 Suppresses Tumor Growth and Stemness Characteristics in HCC by Inhibiting Warburg Effect via WNT/β-Catenin/HK2 Axis

    Researchers reported that the haploinsufficient tumour suppressor ASPP2, could inhibit HCC growth and stemness characteristics by regulating the Warburg effect through the WNT/β-catenin pathway.
    [Journal Of Cellular And Molecular Medicine]

    Full Article

    Periostin Secreted from Podoplanin-Positive Cancer-Associated Fibroblasts Promotes Metastasis of Gastric Cancer by Regulating Cancer Stem Cells via AKT and YAP Signaling Pathway

    Investigators examined a subset of cancer-associated fibroblasts with high podoplanin expression, which is correlated with tumor metastasis and poor survival in gastric cancer patients.
    [Molecular Carcinogenesis]

    Abstract

    The Mechanics of Tumor Cells Dictate Malignancy

    Softening and stiffening tumor cells promoted and suppressed their self-renewal in vitro and tumor formation/growth in vivo, suggesting the regulatory role of cell mechanics in self-renewal and tumorigenicity.
    [Biophysical Journal]

    Abstract

    Differential Contractility Regulates Cancer Stem Cell Migration

    Scientists showed that CSCs maintain increased motility in diverse environments including on 2D elastic polyacrylamide gels of various stiffness, 3D randomly oriented collagen matrices, and ectopic cerebral slices representative of a common metastatic site.
    [Biophysical Journal]

    Abstract

    A Reliable Mouse Model of Liver and Lung Metastasis by Injecting Esophageal Cancer Stem Cells (CSCs) through Tail-Vein Injection

    Investigators developed a mouse model to mimic the late steps of the metastasis process using a tail-vein injection of esophageal CSCs.
    [Molecular Biology Reports]

    Abstract
    Return to your lab safely and efficiently with these guides and resources so that you can focus more on moving your research goals forward.
    REVIEWS

    Epigenetics as a Mediator of Plasticity in Cancer

    Scientists discuss modern approaches to epigenetic and gene regulation landscapes and the associated ideas of entropy and attractor states, illustrating how their definitions are both more precise and relevant to understanding cancer etiology and the plasticity of cancerous states.
    [Science]

    AbstractPress ReleaseGraphical Abstract
    INDUSTRY AND POLICY NEWS

    Cédric Blanpain Receives the 2023 ISSCR Momentum Award

    The International Society for Stem Cell Research (ISSCR) has announced that it will present this year’s ISSCR Momentum Award to Cédric Blanpain, M.D., Ph.D., professor and director of the laboratory of stem cells and cancer at the Université Libre de Bruxelles, Belgium.
    [International Society for Stem Cell Research]

    Press Release
    FEATURED EVENT

    EBMT 49th Annual Meeting

    April 23 – 26, 2023
    Paris, France

    > See All Events

    JOB OPPORTUNITIES

    Research Fellow – Molecular and Cellular Biology

    The University of Melbourne – Melbourne, Australia

    Research Technician – Flow Cytometry

    Howard Hughes Medical Institute – Dallas, Texas, United States

    Chair – ImmunoOncology

    King’s College London – London, England, United Kingdom

    Postdoctoral Research Fellow – Cancer Stem Cells

    Virginia Commonwealth University – Richmond, Virginia, United States

    Program Leader – Basic Science

    Vanderbilt-Ingram Cancer Center – Nashville, Tennessee, United States

    > See All Jobs

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