Cancer Stem Cell News Volume 12.10 | Mar 15 2023

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    2023-03-15 | CSCN 12.10


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 12.10 – 15 March, 2023
    TOP STORY

    Immature Natural Killer Cells Promote Progression of Triple-Negative Breast Cancer

    Tumor samples from patients with triple-negative breast cancer (TNBC) and non-TNBC revealed that increased numbers of CD56bright natural killer cells were present in TNBC tumors, and were correlated to poor overall survival in patients with TNBC.
    [Science Translational Medicine]

    Abstract
    This webinar provides insights and techniques for efficient leukopak sample processing and streamlined cell isolation.
    PUBLICATIONSRanked by the impact factor of the journal

    PVT1 Inhibition Stimulates Anti-Tumor Immunity, Prevents Metastasis, and Depletes Cancer Stem Cells in Squamous Cell Carcinoma

    Scientists identified a long noncoding RNA, termed PVT1, which was highly expressed in CSCs and correlated closely with lymph node metastasis of head and neck squamous cell carcinoma.
    [Cell Death & Disease]

    Full Article

    LncRNA XIST Regulates Breast Cancer Stem Cells by Activating Proinflammatory IL-6/STAT3 Signaling

    Investigators identified X-inactive specific transcript (XIST) as a key regulator of breast CSCs, which exhibit aldehyde dehydrogenase positive epithelial-and CD24loCD44hi mesenchymal-like phenotypes.
    [Oncogene]

    Full Article

    Abemaciclib Drives the Therapeutic Differentiation of Acute Myeloid Leukemia Stem Cells

    To screen drugs to overcome differentiation blockade for acute myeloid leukemia, researchers conducted screening of 2040 small molecules from a library of US FDA-approved drugs and found that the cyclin-dependent kinase 4/6 inhibitor, abemaciclib, exerted high anti-leukemic activity.
    [British Journal Of Haematology]

    Full Article

    Paracrine Secretion of IL8 by Breast Cancer Stem Cells Promotes Therapeutic Resistance and Metastasis of the Bulk Tumor Cells

    Co-culture systems in vitro and co-implantation systems in vivo were designed to characterize the interactions between breast CSCs and bulk cancer cells.
    [Cell Communication and Signaling]

    Full Article

    Near-Infrared Enhances Antiangiogenic Potentiality of Quinacrine-Gold Hybrid Nanoparticles in Breast Cancer Stem Cells via Deregulation of HSP-70/TGF-β

    The authors explored the antiangiogenic mechanism of quinacrine-gold hybrid nanoparticle and near-infrared radiation in patient-derived primary breast CSCs.
    [Nanomedicine]

    AbstractGraphical Abstract

    WDR3 Promotes Stem Cell-Like Properties in Prostate Cancer by Inhibiting USF2-Mediated Transcription of RASSF1A

    WD repeat domain 3 (WDR3) was negatively correlated with USF2, which was degraded by promoting ubiquitination of USF2, and USF2 interacted with promoter region-binding elements of RASSF1A to depress prostate cancer stemness and growth.
    [The Journal Of Gene Medicine]

    Abstract

    In Vivo Detection of Circulating Tumor Cells Predicts High-Risk Features in Patients with Bladder Cancer

    Investigators validated the efficacy of in vivo detection of circulating tumor cells in bladder cancer (BC) patients. A total of 216 BC patients were enrolled in this study.
    [Medical Oncology]

    Abstract

    Metabolic Shift towards Oxidative Phosphorylation Reduces Cell Density-Induced Cancer Stem Cell-Like Characteristics in Prostate Cancer In Vitro

    The authors uncovered the relationship between cell density and CSCs, and the role of the Warburg effect in regulating CSC-like characteristics.
    [Biology Open]

    Abstract
    New human primary cancer-sourced blood products, immune cell subsets, and more. Click to view products.
    REVIEWS

    Biomaterial-Based Platforms for Modulating Immune Components against Cancer and Cancer Stem Cells

    Scientists describe the cutting-edge research undertaken in the field of nanotechnology and material science to develop biomaterials-based platforms as effective immunotherapeutics.
    [Acta Biomaterialia]

    AbstractGraphical Abstract
    INDUSTRY AND POLICY NEWS

    Biden Backs Science in His 2024 Budget Plan. But Don’t Bank on Those Numbers

    The 2024 spending plan President Joe Biden unveiled continues his administration’s pattern of asking for large increases at major US research agencies.
    [Science Insider]

    Press Release
    FEATURED EVENT

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    April 25 – 26, 2023
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    JOB OPPORTUNITIES

    Staff Scientist – Pediatric Brain Tumors

    Dana-Farber Cancer Institute – Boston, Massachusetts, United States

    Postdoctoral Fellow – Cancer and Neurodegenerative Diseases

    University of Pennsylvania – Philadelphia, Pennsylvania, United States

    Postdoctoral Position – Cell Fate Plasticity and Cancer

    The German Cancer Re­search Center – Heidelberg, Germany

    Research Assistant – Epithelial Biology and Dermatology

    Stanford University School of Medicine – Stanford, California, United States

    Research Technician – RNA Vaccines and Therapies

    University of British Columbia – Vancouver, British Columbia, Canada

    > See All Jobs

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