Cancer Stem Cell News Volume 12.18 | May 10 2023

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    2023-05-10 | CSCN 12.18


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 12.18 – 10 May, 2023
    TOP STORY

    Identification and Characterization of the Wilms Tumor Cancer Stem Cell

    A nephrogenic progenitor cell with CSC characteristics driving Wilms tumor using spatial transcriptomics, bulk and single-cell RNA sequencing, and complementary in vitro and transplantation experiments were identified and characterized.
    [Advanced Science]

    Full Article
    Survey results on the insights and hurdles of CRISPR genome editing.
    PUBLICATIONSRanked by the impact factor of the journal

    Bile Exosomal miR-182/183–5p Increases Cholangiocarcinoma Stemness and Progression by Targeting HPGD and Increasing PGE2 Generation

    Exosomes in bile and sera from cholangiocarcinoma, pancreatic cancer, and common bile duct stone were identified and quantified by TEM, NTA, and nanoFCM.
    [Hepatology]

    AbstractGraphical Abstract

    Cancer-Associated Fibroblast–Derived miR-146a-5p Generates a Niche That Promotes Bladder Cancer Stemness and Chemoresistance

    To better understand the mechanisms involved in tumor microenvironment-mediated generation and support of urothelial bladder cancer CSCs, researchers focused on the role of cancer-associated fibroblasts in this study.
    [Cancer Research]

    Abstract
    Graphical Abstract

    Irbesartan Overcomes Gemcitabine Resistance in Pancreatic Cancer by Suppressing Stemness and Iron Metabolism via Inhibition of the Hippo/YAP1/C-jun Axis

    Scientists established a bio-bank of human pancreatic ductal adenocarcinoma (PDAC) organoid models, covering a representative range of PDAC tumor subtypes.
    [Journal of Experimental & Clinical Cancer Research]

    Full Article

    Breast Cancer Stem Cell–Derived Tumors Escape from γδ T-Cell Immunosurveillance In Vivo by Modulating γδ T-Cell Ligands

    Investigators showed that patient-derived triple-negative breast CSCs were efficiently recognized and killed by ex vivo expanded γδ T-cells from healthy donors. Orthotopically xenografted BCSCs, however, were refractory to γδ T-cell immunotherapy.
    [Cancer Immunology Research]

    AbstractPress Release

    TMT-Based Quantitative Proteomic Analysis of Spheroid Cells of Endometrial Cancer Possessing Cancer Stem Cell Properties

    Spheroid cells from endometrial cancer cell lines, Ishikawa and HEC1A, exhibited increased colony forming, subsphere forming, chemo-drug resistance, migration, invasion ability, and tumorigenicity, verifying their cancer stem-like cell properties.
    [Stem Cell Research & Therapy]

    Full Article

    Therapeutic Potential of Pentamidine for Glioma-Initiating Cells and Glioma Cells through Multimodal Antitumor Effects

    Using drug reposition, researchers investigated a therapeutic drug for glioma-initiating cells. Drug screening was undertaken to select candidate agents that inhibit proliferation of two different glioma-initiating cells lines.
    [Cancer Science]

    Full Article

    Enhanced Binding of β-Catenin and β-TrCP Mediates LMPt’s Anti-CSCs Activity in Colorectal Cancer

    The authors reported a liposome loaded with low toxicity and high effectiveness of miriplatin, lipo-miriplatin with high miriplatin loading, and robust stability, exhibiting a superior inhibitory effect on CSCs and non-CSCs.
    [Biochemical Pharmacology]

    AbstractGraphical Abstract

    m6A-Mediated Upregulation of lncRNA-AC026356.1 Promotes Cancer Stem Cell Maintenance in Lung Adenocarcinoma via Activating Wnt Signaling Pathway

    Scientists found that lncRNA-AC026356.1 was upregulated in stem spheres and chemo-resistant lung cancer cells. Fish assay also showed that AC026356.1 was predominantly located in the cytoplasm of lung cancer cells and did not have protein-coding potential.
    [Aging]

    Full Article

    Inorganic Pyrophosphatase 1 Activates the Phosphatidylinositol 3-Kinase/Akt Signaling to Promote Tumorigenicity and Stemness Properties in Colorectal Cancer

    Investigators inspected the functions of inorganic pyrophosphatase 1 (PPA1) in colorectal cancer (CRC). The abundance of PPA1 in CRC tissues was analyzed by utilizing publicly available data from the The Cancer Genome Atlas and Human Protein Atlas project.
    [Cellular Signalling]

    Abstract

    ZNF677 Inhibits Oral Squamous Cell Carcinoma Growth and Tumor Stemness by Regulating FOXO3a

    The expression of ZNF677 was analyzed by online database and immunohistochemistry, while the methylation level of ZNF677 was determined by the methylation-specific PCR.
    [Human Cell]

    Abstract

    Integrative Analysis Developing and Validating Potential Candidate Biomarkers for Cancer Stemness Features of Pan-Renal Cell Carcinoma

    49 key genes significantly associated with renal cell carcinoma (RCC) stemness were obtained. Next, scientists developed a molecular prognostic signature associated with stemness features of pan-RCC.
    [Cancer Investigation]

    Abstract
    New human primary cancer-sourced blood products, immune cell subsets, and more. Click to view products.
    REVIEWS

    Cancer Stem Cells: An Insight into the Development of Metastatic Tumors and Therapy Resistance

    The authors elucidate the critical role of CSCs in the onset and spread of cancer and the characteristics of CSCs that promote severe resistance to targeted therapy.
    [Stem Cell Reviews and Reports]

    AbstractGraphical Abstract
    INDUSTRY AND POLICY NEWS

    CIHR Joins New Initiative to Accelerate Progress against Cancer Worldwide

    The Canadian Institutes of Health Research (CIHR) and CIHR’s Institute of Cancer Research are among the founding members of G7 Cancer, led by the French Institut national du cancer.
    [Canadian Institutes
    of Health Research]

    Press Release

    NIH Grants $6.2M for Cancer Studies at Sanford Research

    Sanford Research was recently awarded a $6.2 million grant from the National Institutes of Health for its continued cancer research in the upper Midwest.
    [Sanford Health]

    Press Release
    FEATURED EVENT

    11th International Meeting of the Stem Cell Network 2023

    May 16 – 17, 2023
    Aachen, Germany

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Oncology and Immunology

    Centre for Oncology and Immunology – Hong Kong

    Research Fellow – Aging and Cancer Stem Cell

    The National University of Singapore – Singapore, Singapore

    Postdoctoral Research Associate – Oncology

    St. Jude Children’s Research Hospital – Memphis, Tennessee, United States

    Postdoctoral Fellow – Cancer Biology

    Wake Forest University – Winston Salem, North Carolina, United States

    Postdoctoral Position – Cancer Metabolism, Epigenetics, and Hematopoiesis Research

    University of Texas Health Science Center – San Antonio, Texas, United States

    > See All Jobs

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