 | | Vol. 12.18 – 10 May, 2023 |
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| A nephrogenic progenitor cell with CSC characteristics driving Wilms tumor using spatial transcriptomics, bulk and single-cell RNA sequencing, and complementary in vitro and transplantation experiments were identified and characterized.
[Advanced Science] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Exosomes in bile and sera from cholangiocarcinoma, pancreatic cancer, and common bile duct stone were identified and quantified by TEM, NTA, and nanoFCM.
[Hepatology] |
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| To better understand the mechanisms involved in tumor microenvironment-mediated generation and support of urothelial bladder cancer CSCs, researchers focused on the role of cancer-associated fibroblasts in this study.
[Cancer Research] |
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| Scientists established a bio-bank of human pancreatic ductal adenocarcinoma (PDAC) organoid models, covering a representative range of PDAC tumor subtypes.
[Journal of Experimental & Clinical Cancer Research] |
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| Investigators showed that patient-derived triple-negative breast CSCs were efficiently recognized and killed by ex vivo expanded γδ T-cells from healthy donors. Orthotopically xenografted BCSCs, however, were refractory to γδ T-cell immunotherapy.
[Cancer Immunology Research] |
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| Spheroid cells from endometrial cancer cell lines, Ishikawa and HEC1A, exhibited increased colony forming, subsphere forming, chemo-drug resistance, migration, invasion ability, and tumorigenicity, verifying their cancer stem-like cell properties.
[Stem Cell Research & Therapy] |
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| Using drug reposition, researchers investigated a therapeutic drug for glioma-initiating cells. Drug screening was undertaken to select candidate agents that inhibit proliferation of two different glioma-initiating cells lines.
[Cancer Science] |
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| The authors reported a liposome loaded with low toxicity and high effectiveness of miriplatin, lipo-miriplatin with high miriplatin loading, and robust stability, exhibiting a superior inhibitory effect on CSCs and non-CSCs.
[Biochemical Pharmacology] |
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| Scientists found that lncRNA-AC026356.1 was upregulated in stem spheres and chemo-resistant lung cancer cells. Fish assay also showed that AC026356.1 was predominantly located in the cytoplasm of lung cancer cells and did not have protein-coding potential.
[Aging] |
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| Investigators inspected the functions of inorganic pyrophosphatase 1 (PPA1) in colorectal cancer (CRC). The abundance of PPA1 in CRC tissues was analyzed by utilizing publicly available data from the The Cancer Genome Atlas and Human Protein Atlas project.
[Cellular Signalling] |
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| The expression of ZNF677 was analyzed by online database and immunohistochemistry, while the methylation level of ZNF677 was determined by the methylation-specific PCR.
[Human Cell] |
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| 49 key genes significantly associated with renal cell carcinoma (RCC) stemness were obtained. Next, scientists developed a molecular prognostic signature associated with stemness features of pan-RCC.
[Cancer Investigation] |
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| The authors elucidate the critical role of CSCs in the onset and spread of cancer and the characteristics of CSCs that promote severe resistance to targeted therapy.
[Stem Cell Reviews and Reports] |
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| The Canadian Institutes of Health Research (CIHR) and CIHR’s Institute of Cancer Research are among the founding members of G7 Cancer, led by the French Institut national du cancer.
[Canadian Institutes
of Health Research] |
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| Sanford Research was recently awarded a $6.2 million grant from the National Institutes of Health for its continued cancer research in the upper Midwest.
[Sanford Health] |
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| May 16 – 17, 2023
Aachen, Germany |
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| | Centre for Oncology and Immunology – Hong Kong |
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| | The National University of Singapore – Singapore, Singapore |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | Wake Forest University – Winston Salem, North Carolina, United States |
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| | University of Texas Health Science Center – San Antonio, Texas, United States |
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Cancer Stem Cell News
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