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Vol. 12.18 – 10 May, 2023
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A nephrogenic progenitor cell with CSC characteristics driving Wilms tumor using spatial transcriptomics, bulk and single-cell RNA sequencing, and complementary in vitro and transplantation experiments were identified and characterized.
[Advanced Science]
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PUBLICATIONSRanked by the impact factor of the journal
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Exosomes in bile and sera from cholangiocarcinoma, pancreatic cancer, and common bile duct stone were identified and quantified by TEM, NTA, and nanoFCM.
[Hepatology]
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To better understand the mechanisms involved in tumor microenvironment-mediated generation and support of urothelial bladder cancer CSCs, researchers focused on the role of cancer-associated fibroblasts in this study.
[Cancer Research]
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Scientists established a bio-bank of human pancreatic ductal adenocarcinoma (PDAC) organoid models, covering a representative range of PDAC tumor subtypes.
[Journal of Experimental & Clinical Cancer Research]
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Investigators showed that patient-derived triple-negative breast CSCs were efficiently recognized and killed by ex vivo expanded γδ T-cells from healthy donors. Orthotopically xenografted BCSCs, however, were refractory to γδ T-cell immunotherapy.
[Cancer Immunology Research]
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Spheroid cells from endometrial cancer cell lines, Ishikawa and HEC1A, exhibited increased colony forming, subsphere forming, chemo-drug resistance, migration, invasion ability, and tumorigenicity, verifying their cancer stem-like cell properties.
[Stem Cell Research & Therapy]
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Using drug reposition, researchers investigated a therapeutic drug for glioma-initiating cells. Drug screening was undertaken to select candidate agents that inhibit proliferation of two different glioma-initiating cells lines.
[Cancer Science]
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The authors reported a liposome loaded with low toxicity and high effectiveness of miriplatin, lipo-miriplatin with high miriplatin loading, and robust stability, exhibiting a superior inhibitory effect on CSCs and non-CSCs.
[Biochemical Pharmacology]
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Scientists found that lncRNA-AC026356.1 was upregulated in stem spheres and chemo-resistant lung cancer cells. Fish assay also showed that AC026356.1 was predominantly located in the cytoplasm of lung cancer cells and did not have protein-coding potential.
[Aging]
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Investigators inspected the functions of inorganic pyrophosphatase 1 (PPA1) in colorectal cancer (CRC). The abundance of PPA1 in CRC tissues was analyzed by utilizing publicly available data from the The Cancer Genome Atlas and Human Protein Atlas project.
[Cellular Signalling]
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The expression of ZNF677 was analyzed by online database and immunohistochemistry, while the methylation level of ZNF677 was determined by the methylation-specific PCR.
[Human Cell]
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49 key genes significantly associated with renal cell carcinoma (RCC) stemness were obtained. Next, scientists developed a molecular prognostic signature associated with stemness features of pan-RCC.
[Cancer Investigation]
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The authors elucidate the critical role of CSCs in the onset and spread of cancer and the characteristics of CSCs that promote severe resistance to targeted therapy.
[Stem Cell Reviews and Reports]
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The Canadian Institutes of Health Research (CIHR) and CIHR’s Institute of Cancer Research are among the founding members of G7 Cancer, led by the French Institut national du cancer.
[Canadian Institutes
of Health Research]
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Sanford Research was recently awarded a $6.2 million grant from the National Institutes of Health for its continued cancer research in the upper Midwest.
[Sanford Health]
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May 16 – 17, 2023
Aachen, Germany
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Centre for Oncology and Immunology – Hong Kong
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The National University of Singapore – Singapore, Singapore
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St. Jude Children’s Research Hospital – Memphis, Tennessee, United States
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Wake Forest University – Winston Salem, North Carolina, United States
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University of Texas Health Science Center – San Antonio, Texas, United States
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
Umbilical & Placental Cell News