Cancer Stem Cell News Volume 12.20 | May 24 2023


    2023-05-24 | CSCN 12.20

    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 12.20 – 24 May, 2023

    Palmitoyltransferase ZDHHC21 Regulates Oxidative Phosphorylation to Induce Differentiation Block and Stemness in AML

    Scientists demonstrated for the first time that ZDHHC21 palmitoyltransferase served as a key regulator of oxidative phosphorylation hyperactivity in acute myeloid leukemia (AML) cells.

    New human primary cancer-sourced blood products, immune cell subsets, and more. Click to view products.
    PUBLICATIONSRanked by the impact factor of the journal

    Metabolic Adaptation to Tyrosine Kinase Inhibition in Leukemia Stem Cells

    Researchers performed a comprehensive evaluation of metabolic adaptation to tyrosine kinase inhibitor treatment and its role in chronic myelogenous leukemia hematopoietic stem and progenitor cell persistence.


    A Self-Propagating c-Met–SOX2 Axis Drives Cancer-Derived IgG Signaling That Promotes Lung Cancer Cell Stemness

    Investigators conducted genome-wide CRISPR activation screening and identified OCT4 and SOX2 as the key factors that promoted sialylated cancer IgG expression.
    [Cancer Research]

    Graphical Abstract

    Terminally Exhausted CD8+ T Cells Resistant to PD-1 Blockade Promote Generation and Maintenance of Aggressive Cancer Stem Cells

    Scientists reported that terminally exhausted (TTEX) cells actively participated in tumor progression by modulating CSCs. TTEX cells strongly correlated with elevated CSC frequency in poorly immune-infiltrated advanced human breast and ovarian carcinomas.
    [Cancer Research]


    MSC-NPRA Loop Drives Fatty Acid Oxidation to Promote Stemness and Chemoresistance of Gastric Cancer

    The chemoresistance and stemness of gastric cancer cells were observed by colony formation, CCK-8, sphere formation, and flow cytometry assays. Cell lines and animal models were utilized to investigate related functions.
    [Cancer Letters]


    A Novel Stemness Classification in Acute Myeloid Leukemia by the Stemness Index and the Identification of Cancer Stem Cell-Related Biomarkers

    The authors characterized stem cell-related gene expression and identified stemness biomarker genes in acute myeloid leukemia. They calculated the stemness index based on transcription data using the one-class logistic regression algorithm for patients in the training set.
    [Frontiers In Immunology]


    Brg1 Controls Stemness and Metastasis of Pancreatic Cancer through Regulating Hypoxia Pathway

    Scientists investigated the importance of Brg1 for established pancreatic ductal adenocarcinoma by using a mouse model with a dual recombinase system.


    Novel and Efficient Method for Culturing Patient-Derived Gastric Cancer Stem Cells

    To propagate gastric cancer cells as highly proliferative stem-cell spheroids in vitro, researchers initially used a similar method to that for colorectal cancer stem cells, which resulted in a low success rate.
    [Cancer Science]


    Targeting PCSK9 Reduces Cancer Cell Stemness and Enhances Antitumor Immunity in Head and Neck Cancer

    Investigators found that the expression of proprotein convertase subtilisin/kexin type 9 (PCSK9) was upregulated in head and neck squamous cell carcinoma (HNSCC) tissues, and higher PCSK9 expression indicated poorer prognosis in HNSCC patients.

    AbstractFull ArticleGraphical Abstract

    Hairy Gene Homolog Increases Nasopharyngeal Carcinoma Cell Stemness by Upregulating Bmi-1

    Scientists found that B-cell-specific Moloney murine leukemia virus integration site 1 (Bmi-1) mRNA levels were elevated in nasopharyngeal carcinoma cell lines.


    Erianin Suppressed Lung Cancer Stemness and Chemotherapeutic Sensitivity via Triggering Ferroptosis

    To investigate the effects of Erianin on lung cancer stemness, researchers screened various concentrations of Erianin to ensure that it did not affect lung cancer cell viability.
    [Environmental Toxicology]

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    Harnessing Cancer Stem Cell-Derived Exosomes to Improve Cancer Therapy

    To provide an overview of the possible role of CSC‐derived exosomes and targeting strategies, the authors summarize relevant research progress and highlight the potential impact of detecting or targeting CSC‐derived exosomes on cancer treatment.
    [Journal of Experimental & Clinical Cancer Research]

    Full Article

    Victorian Government Funds Pediatric Cancer Research

    As a partner in the Victorian Pediatric Cancer Consortium, Hudson Institute of Medical Research welcomes the commitment of $35 million, which will boost their efforts to find new treatments and cures, as well as improving quality of life for children who survive cancer.
    [Hudson Institute of Medical Research]

    Press Release

    Two Penn Medicine Abramson Cancer Center Faculty Members Receive Top ASCO Awards

    Two leaders from the Penn Medicine Abramson Cancer Center will be honored with 2023 Special Awards from the American Society for Clinical Oncology (ASCO), and Conquer Cancer, the ASCO Foundation, during the 2023 ASCO Annual Meeting.
    [Penn Medicine News]

    Press Release

    The Aging Genome: From Mechanisms to Disease

    June 4 – 7, 2023
    Heidelberg, Germany

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    Postdoctoral Associate – Pediatrics

    Baylor College of Medicine – Houston, Texas, United States

    PhD Position – Tumor Tissue Engineering

    Université de Lausanne – Lausanne, Switzerland

    Postdoctoral Fellow – Cancer Research

    Georgia Cancer Center at Augusta University – Augusta, Georgia, United States

    Postdoctoral Associate – Chromatin Mechanisms

    Virginia Tech – Washington, DC, United States

    Junior Lab Technician – Cancer Research

    VIB – Leuven, Belgium

    > See All Jobs

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