 | | Vol. 12.21 – 31 May, 2023 |
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| With omics and functional assays deploying patient-derived in vitro and in vivo models, scientists showed that macroH2A2 shaped chromatin accessibility at enhancer elements to antagonize transcriptional programs of self-renewal.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Using small-molecule modulators and genetic perturbations, researchers identified a synergistic interaction between FOXG1 and Wnt/β-catenin signaling.
[Cell Reports] |
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| The authors investigated the biological functions and mechanisms involved in the SET and MYND domain-containing protein 3 (SMYD3)-mediated tumorigenesis of oral squamous cell carcinoma utilizing bioinformatic approaches and validation assays.
[Clinical Epigenetics] |
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| Scientists reported for the first time that JWA was significantly downregulated in smoking-related lung cancer and associated with overall survival. Nicotine exposure reduced JWA expression in a dose-dependent manner.
[Ecotoxicology and Environmental Safety] |
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| Researchers showed that the AKT-mediated phosphorylation of the transcription elongation factor IWS1, promoted the maintenance of CSCs in both cell and xenograft models of liposarcoma.
[Oncogenesis] |
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| The authors investigated the altered lncRNAs upon endoplasmic reticulum (ER) stress in glioma and found that small nucleolar RNA host gene 1 (SNHG1) was markedly increased in response to ER stress.
[Journal of Cellular and Molecular Medicine] |
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| After gastric CSCs were isolated, it was found that fat mass and obesity (FTO) protein expression was increased in gastric CSCs and stemness of gastric cancer cells was reduced after the FTO gene knockdown.
[Dna And Cell Biology] |
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| Researchers treated glioma cells with isoliquiritigenin (ISL), and circRNA expression levels were detected. Circ0030018 was found significantly downregulated by ISL. They explored circ0030018 expression profiles and functions in glioma.
[MedComm] |
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| The authors review the biological significance of stemness and the results of potential colorectal CSC (CRCSC)-based targeted immunotherapies. They point out the barriers to targeting CRCSCs in vivo and highlight new strategies based on synthetic and biogenic nanocarriers for future anti-CRCSC trials.
[Journal of Gastrointestinal Cancer] |
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| A post-doctoral researcher at Queen’s University Cancer Research Institute has been recognized nationally for her groundbreaking work to monitor breast cancer using a simple, routine blood test.
[Queen’s University] |
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| Trethera Corporation announced that it was awarded a $2 million Small Business Innovative Research grant from the National Cancer Institute. The grant will fund additional patient dosing studies to identify predictive biomarkers of activity and target engagement of TRE-515 in solid tumors.
[Trethera Corporation (GlobeNewswire)] |
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| June 13 – 17, 2023
Lugano, Switzerland |
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| | NIH National Cancer Institute – Bethesda, Maryland, United States |
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| | Vlaams Instituut voor Biotechnologie – Ghent, Belgium |
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| | University of Galway – Galway, Ireland |
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| | Institute of Cancer Research – London, England, United Kingdom |
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| | Human Technopole – Milan, Italy |
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