Cancer Stem Cell News Volume 12.21 | May 31 2023

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    2023-05-31 | CSCN 12.21


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 12.21 – 31 May, 2023
    TOP STORY

    macroH2A2 Antagonizes Epigenetic Programs of Stemness in Glioblastoma

    With omics and functional assays deploying patient-derived in vitro and in vivo models, scientists showed that macroH2A2 shaped chromatin accessibility at enhancer elements to antagonize transcriptional programs of self-renewal.
    [Nature Communications]

    Full Article
    New human primary cancer-sourced blood products, immune cell subsets, and more. Click to view products.
    PUBLICATIONSRanked by the impact factor of the journal

    Elevated FOXG1 in Glioblastoma Stem Cells Cooperates with Wnt/β-Catenin To Induce Exit From Quiescence

    Using small-molecule modulators and genetic perturbations, researchers identified a synergistic interaction between FOXG1 and Wnt/β-catenin signaling.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Histone Lysine Methyltransferase SMYD3 Promotes Oral Squamous Cell Carcinoma Tumorigenesis via H3K4me3-Mediated HMGA2 Transcription

    The authors investigated the biological functions and mechanisms involved in the SET and MYND domain-containing protein 3 (SMYD3)-mediated tumorigenesis of oral squamous cell carcinoma utilizing bioinformatic approaches and validation assays.
    [Clinical Epigenetics]

    Full Article

    JWA Inhibits Nicotine-Induced Lung Cancer Stemness and Progression through CHRNA5/AKT-Mediated JWA/SP1/CD44 Axis

    Scientists reported for the first time that JWA was significantly downregulated in smoking-related lung cancer and associated with overall survival. Nicotine exposure reduced JWA expression in a dose-dependent manner.
    [Ecotoxicology and Environmental Safety]

    Full ArticleGraphical Abstract

    Phosphorylation of IWS1 by AKT Maintains Liposarcoma Tumor Heterogeneity through Preservation of Cancer Stem Cell Phenotypes and Mesenchymal-Epithelial Plasticity

    Researchers showed that the AKT-mediated phosphorylation of the transcription elongation factor IWS1, promoted the maintenance of CSCs in both cell and xenograft models of liposarcoma.
    [Oncogenesis]

    Full Article

    SNHG1, a KLF4-Upregulated Gene, Promotes Glioma Cell Survival and Tumorigenesis under Endoplasmic Reticulum Stress by Upregulating BIRC3 Expression

    The authors investigated the altered lncRNAs upon endoplasmic reticulum (ER) stress in glioma and found that small nucleolar RNA host gene 1 (SNHG1) was markedly increased in response to ER stress.
    [Journal of Cellular and Molecular Medicine]

    Full Article

    FTO Promotes the Stemness of Gastric Cancer Cells

    After gastric CSCs were isolated, it was found that fat mass and obesity (FTO) protein expression was increased in gastric CSCs and stemness of gastric cancer cells was reduced after the FTO gene knockdown.
    [Dna And Cell Biology]

    Abstract

    Isoliquiritigenin Inhibits circ0030018 To Suppress Glioma Tumorigenesis via the miR-1236/HER2 Signaling Pathway

    Researchers treated glioma cells with isoliquiritigenin (ISL), and circRNA expression levels were detected. Circ0030018 was found significantly downregulated by ISL. They explored circ0030018 expression profiles and functions in glioma.
    [MedComm]

    Full Article
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    REVIEWS

    Cancer Stem Cells in Colorectal Cancer: Implications for Targeted Immunotherapies

    The authors review the biological significance of stemness and the results of potential colorectal CSC (CRCSC)-based targeted immunotherapies. They point out the barriers to targeting CRCSCs in vivo and highlight new strategies based on synthetic and biogenic nanocarriers for future anti-CRCSC trials.
    [Journal of Gastrointestinal Cancer]

    Abstract
    INDUSTRY AND POLICY NEWS

    Researcher Receives National Award for Cancer Care Innovation

    A post-doctoral researcher at Queen’s University Cancer Research Institute has been recognized nationally for her groundbreaking work to monitor breast cancer using a simple, routine blood test.
    [Queen’s University]

    Press Release

    Trethera Receives $2 Million National Cancer Institute Grant for Advancement of Clinically Relevant Biomarkers in Phase I Trial

    Trethera Corporation announced that it was awarded a $2 million Small Business Innovative Research grant from the National Cancer Institute. The grant will fund additional patient dosing studies to identify predictive biomarkers of activity and target engagement of TRE-515 in solid tumors.
    [Trethera Corporation (GlobeNewswire)]

    Press Release
    FEATURED EVENT

    International Conference on Malignant Lymphoma

    June 13 – 17, 2023
    Lugano, Switzerland

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellowships – Cancer Research

    NIH National Cancer Institute – Bethesda, Maryland, United States

    Research Associate – Cancer Research

    Vlaams Instituut voor Biotechnologie – Ghent, Belgium

    Postdoctoral Researcher – Cell Stress Response

    University of Galway – Galway, Ireland

    Postdoctoral Training Fellow – Cancer Stem Cell

    Institute of Cancer Research – London, England, United Kingdom

    Postdoctoral Position – Machine Learning for Cancer Pharmacogenomics

    Human Technopole – Milan, Italy

    > See All Jobs

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