Cancer Stem Cell News Volume 12.22 | Jun 7 2023


    2023-06-07 | CSCN 12.22

    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 12.22 – 7 June, 2023

    Oxidative Phosphorylation Fueled by Fatty Acid Oxidation Sensitizes Leukemic Stem Cells to Cold

    Investigators identified cold sensitivity at 4°C, commonly used for sample storage, as a novel vulnerability that selectively killed acute myeloid leukemic stem cells with active fatty acid oxidation-supported mitochondrial oxidative phosphorylation while sparing normal hematopoietic stem cells.
    [Cancer Research]

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    Aldehyde Dehydrogenase, a Marker of Normal and Malignant Stem Cells, Typifies Mesenchymal Progenitors in Perivascular Niches

    The authors evaluated the activity of aldehyde dehydrogenase, a family of enzymes catalyzing the oxidation of aldehydes into carboxylic acids and a reported biomarker of normal and malignant stem cells, within human adipose tissue perivascular areas.
    [Stem Cells Translational Medicine]

    Full ArticleGraphical Abstract

    Acute Myeloid Leukemia (AML)-Derived Mesenchymal Stem Cells Induce Chemoresistance and Epithelial-Mesenchymal Transition-Like Program in AML through IL-6/JAK2/STAT3 Signaling

    Researchers found that AML-mesenchymal stem cells induced a significant mesenchymal-like morphology in drug-resistant AML cells, but it was scarce in parental AML cells.
    [Cancer Science]

    Full Article

    Therapeutic Inhibition of BMI-1 Ablates Chemoresistant Cancer Stem Cells in Adenoid Cystic Carcinoma

    Therapeutic efficacy of a small molecule inhibitor of Bmi-1 and/or Cisplatin on adenoid cystic carcinoma (ACC) stemness was evaluated in immunodeficient mice harboring PDX ACC tumors, and in human ACC cell-lines, or low passage primary human ACC cells.
    [Oral Oncology]

    Full ArticleGraphical Abstract

    Insulin-Like Growth Factor (IGF) and Hepatocyte Growth Factor (HGF) in Follicular Fluid Cooperatively Promote the Oncogenesis of High-Grade Serous Carcinoma from Fallopian Tube Epithelial Cells: Dissection of the Molecular Effects

    In a mouse xenograft co-injection model, investigators observed that ovulatory follicular fluid co-injection induced tumorigenesis of serous tubal intraepithelial carcinoma-mimicking cells, FE25.
    [Molecular Carcinogenesis]


    SETD4 Confers Cancer Stem Cell Chemoresistance in Nonsmall Cell Lung Cancer Patients via the Epigenetic Regulation of Cellular Quiescence

    SET domain-containing protein 4 (SETD4)-positive cells were identified as quiescent lung cancer stem cells, since they expressed high levels of ALDH1 and CD133 and low levels of Ki67.
    [Stem Cells International]

    Full Article

    MT1M Regulates Gastric Cancer Progression and Stemness by Modulating the Hedgehog Pathway Protein GLI1

    Scientists investigated the expression and function of metallothionein 1 M (MT1M) in gastric cancer (GC) both in vitro and in vivo, and found that MT1M expression was significantly downregulated in GC tissues and cell lines.
    [Biochemical And Biophysical Research Communications]

    AbstractGraphical Abstract

    High Expression of PKCλ and ALDH1A3 Indicates a Poor Prognosis, and PKCλ Is Required for the Asymmetric Cell Division of ALDH1A3-Positive Cancer Stem Cells in PDAC

    To monitor asymmetric cell division of ALDH1A3-positive pancreatic ductal adenocarcinoma (PDAC) CSCs, researchers established stable Panc-1 PDAC clones expressing ALDH1A3-turboGFP.
    [Biochemical And Biophysical Research Communications]

    Full Article

    Structural Modification of Resveratrol Analogue Exhibits Anticancer Activity against Lung Cancer Stem Cells via Suppression of Akt Signaling Pathway

    CSC-rich populations of A549 cells were generated, and CSC markers, and Akt signaling were determined by Western blot analysis and immunofluorescence.
    [BMC Complementary Medicine And Therapies]

    Full Article
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    Circulating Tumor Cells for Early Detection of Clinically Relevant Cancer

    The authors discuss the clinical significance of early haematogenous dissemination of cancer cells, the potential of circulating tumor cells (CTC) to facilitate early detection of clinically relevant cancers, and the technological advances that might improve CTC capture and, thus, diagnostic performance in this setting.
    [Nature Reviews Clinical Oncology]


    Non-Lethal Outcomes of Engaging Regulated Cell Death Pathways in Cancer

    Regulated cell death (RCD) is essential for successful systemic cancer therapy. Cells which survive RCD pathways harbor important functions, which can be exploited by cancer cells to promote their own survival and growth, with challenges and opportunities for cancer therapy.
    [Nature Cancer]

    Full Article

    Council Calls for Transparent, Equitable, and Open Access to Scholarly Publications

    The Council of the European Union has adopted conclusions on the ‘high quality, transparent, open, trustworthy and equitable scholarly publishing’, in which it calls for immediate and unrestricted open access in publishing research involving public funds.
    [Council of the European Union]

    Press Release

    Precigen Receives FDA Clearance of IND to Initiate Phase II Study of PRGN-2009 Off-the-Shelf AdenoVerse Immunotherapy in Combination with Pembrolizumab to Treat Patients with Recurrent or Metastatic Cervical Cancer

    The Phase II randomized, open-label, two-arm, multicenter study will evaluate the efficacy and safety of PRGN-2009 in combination with pembrolizumab versus pembrolizumab monotherapy in patients with recurrent or metastatic cervical cancer who are pembrolizumab resistant.
    [Precigen, Inc.]

    Press Release

    Stem Cells, Cell Therapies, and Bioengineering in Lung Biology and Diseases

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