 | | Vol. 12.22 – 7 June, 2023 |
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| Investigators identified cold sensitivity at 4°C, commonly used for sample storage, as a novel vulnerability that selectively killed acute myeloid leukemic stem cells with active fatty acid oxidation-supported mitochondrial oxidative phosphorylation while sparing normal hematopoietic stem cells.
[Cancer Research] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors evaluated the activity of aldehyde dehydrogenase, a family of enzymes catalyzing the oxidation of aldehydes into carboxylic acids and a reported biomarker of normal and malignant stem cells, within human adipose tissue perivascular areas.
[Stem Cells Translational Medicine] |
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| Researchers found that AML-mesenchymal stem cells induced a significant mesenchymal-like morphology in drug-resistant AML cells, but it was scarce in parental AML cells.
[Cancer Science] |
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| Therapeutic efficacy of a small molecule inhibitor of Bmi-1 and/or Cisplatin on adenoid cystic carcinoma (ACC) stemness was evaluated in immunodeficient mice harboring PDX ACC tumors, and in human ACC cell-lines, or low passage primary human ACC cells.
[Oral Oncology] |
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| In a mouse xenograft co-injection model, investigators observed that ovulatory follicular fluid co-injection induced tumorigenesis of serous tubal intraepithelial carcinoma-mimicking cells, FE25.
[Molecular Carcinogenesis] |
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| SET domain-containing protein 4 (SETD4)-positive cells were identified as quiescent lung cancer stem cells, since they expressed high levels of ALDH1 and CD133 and low levels of Ki67.
[Stem Cells International] |
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| Scientists investigated the expression and function of metallothionein 1 M (MT1M) in gastric cancer (GC) both in vitro and in vivo, and found that MT1M expression was significantly downregulated in GC tissues and cell lines.
[Biochemical And Biophysical Research Communications] |
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| To monitor asymmetric cell division of ALDH1A3-positive pancreatic ductal adenocarcinoma (PDAC) CSCs, researchers established stable Panc-1 PDAC clones expressing ALDH1A3-turboGFP.
[Biochemical And Biophysical Research Communications] |
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| CSC-rich populations of A549 cells were generated, and CSC markers, and Akt signaling were determined by Western blot analysis and immunofluorescence.
[BMC Complementary Medicine And Therapies] |
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| The authors discuss the clinical significance of early haematogenous dissemination of cancer cells, the potential of circulating tumor cells (CTC) to facilitate early detection of clinically relevant cancers, and the technological advances that might improve CTC capture and, thus, diagnostic performance in this setting.
[Nature Reviews Clinical Oncology] |
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| Regulated cell death (RCD) is essential for successful systemic cancer therapy. Cells which survive RCD pathways harbor important functions, which can be exploited by cancer cells to promote their own survival and growth, with challenges and opportunities for cancer therapy.
[Nature Cancer] |
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| The Council of the European Union has adopted conclusions on the ‘high quality, transparent, open, trustworthy and equitable scholarly publishing’, in which it calls for immediate and unrestricted open access in publishing research involving public funds.
[Council of the European Union] |
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| The Phase II randomized, open-label, two-arm, multicenter study will evaluate the efficacy and safety of PRGN-2009 in combination with pembrolizumab versus pembrolizumab monotherapy in patients with recurrent or metastatic cervical cancer who are pembrolizumab resistant.
[Precigen, Inc.] |
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| July 17 – 20, 2023
Burlington, Vermont, United States |
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| | The University of New South Wales – Sydney, Australia |
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| | Institut Pasteur – Paris, France |
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| | NIH National Cancer Institute – Bethesda, Maryland, United States |
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| | Vlaams Instituut voor Biotechnologie – Ghent, Belgium |
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| | Human Technopole – Milan, Italy |
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