Cancer Stem Cell News Volume 13.12 | May 1 2024

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    2024-05-01 | CSCN 13.12


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 13.12 – 1 May, 2024
    TOP STORY

    Precise Capture and Dynamic Release of Circulating Liver Cancer Cells with Dual-Histidine-Based Cell Imprinted Hydrogels

    Scientists designed an ultra-strong ligand, L-histidine–L-histidine, specifically targeting sialylated glycans on the surface of circulating tumor cells.
    [Advanced Materials]

    Abstract
    PUBLICATIONSRanked by the impact factor of the journal

    The pRb/RBL2-E2F1/4-GCN5 Axis Regulates Cancer Stem Cell Formation and G0 Phase Entry/Exit by Paracrine Mechanisms

    Investigators used a quantitative proteomic approach for identifying secreted proteins of CSCs in pancreatic cancer. They uncovered that the cell-autonomous E2F1/4-pRb/RBL2 axis balanced non-cell-autonomous signaling in healthy ductal cells but became deregulated upon KRAS mutation.
    [Nature Communications]

    Full Article

    Macrophage-Fibroblast JAK/STAT Dependent Crosstalk Promotes Liver Metastatic Outgrowth in Pancreatic Cancer

    Scientists identified three functionally distinct metastasis-associated fibroblast populations, among which the generation of pro-metastatic and immunoregulatory myofibroblastic-MAFs critically depended on macrophages.
    [Nature Communications]

    Full Article

    Integrated Drug Profiling and CRISPR Screening Identify BCR::ABL1-Independent Vulnerabilities in Chronic Myeloid Leukemia

    The authors performed ex vivo drug screening of CML CD34+ leukemic stem/progenitor cells using 100 single drugs and tyrosine kinase inhibitor-drug combinations and identify sensitivities to Wee1, MDM2, and BCL2 inhibitors.
    [Cell Reports Medicine]

    Full ArticleGraphical Abstract

    Genetic and Phenotypic Profiling of Single Living Circulating Tumor Cells from Patients with Microfluidics

    Researchers described the nanoplatform for interrogating living cell host-gene and (micro-)environment relationships, that integrates micro- and nanofluidics to enable highly efficient capture of circulating tumor cells from blood samples.
    [Proceedings Of The National Academy Of Sciences Of The United States Of America]

    Abstract

    Oncolytic Herpes Simplex Virus Expressing IL-2 Controls Glioblastoma Growth and Improves Survival

    The authors developed G47Δ-mIL2 using the flip-flop herpes simplex virus BAC system to deliver IL-2 locally within the tumor microenvironment.
    [Journal For Immunotherapy Of Cancer]

    Abstract

    The CD33xCD123xCD70 Multispecific CD3-Engaging DARPin MP0533 Induces Selective T Cell–Mediated Killing of AML Leukemic Stem Cells

    Researchers designed MP0533, a multispecific CD3-engaging designed ankyrin repeat protein that could simultaneously bind to three antigens on AML cells, CD33, CD123, and CD70, aiming to enable avidity-driven T cell–mediated killing of AML cells co-expressing at least two of the antigens.
    [Cancer Immunology Research]

    Abstract

    Identification of a Set of Genes Potentially Responsible for Resistance to Ferroptosis in Lung Adenocarcinoma Cancer Stem Cells

    The authors observed that the ferroptosis inducer RSL3 triggered lipid peroxidation and cell death in lung adenocarcinoma cells when grown in 2D conditions; however, when grown in 3D conditions, all cell lines underwent a phenotypic switch.
    [Cell Death & Disease]

    Full ArticleGraphical Abstract

    Bortezomib Suppresses Acute Myelogenous Leukemia Stem-Like KG-1a Cells via NF-κB Inhibition and the Induction of Oxidative Stress

    Scientists investigated the anti-acute myelogenous leukemia (AML) activity of bortezomib, emphasizing its anti-leukemic stem cells potential, using KG-1a cells, an AML cell line with stem-like properties.
    [Journal Of Cellular And Molecular Medicine]

    Full Article

    NAT10-Mediated ac4C Modification Promotes Stemness and Chemoresistance of Colon Cancer by Stabilizing NANOGP8

    The levels of NAT10 in normal colon and chemoresistant colon cancer tissues were determined utilizing quantitative real-time polymerase chain reaction alongside immunohistochemistry.
    [Heliyon]

    Full Article
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    REVIEWS

    Circadian Regulation of Cancer Stem Cells and the Tumor Microenvironment During Metastasis

    The authors review how the circadian clock influences CSCs and their local tumor niches in the context of different stages of tumor metastasis.
    [Nature Cancer]

    Abstract
    INDUSTRY AND POLICY NEWS

    Dutch Cancer Society Grant to Study How Fatty Liver Disease Can Contribute to Liver Cancer

    Delilah Hendriks, researcher from the Organoid group, Oncode researcher, and affiliated group leader at the Princess Máxima Center has received a Young Investigator Grant from the Dutch Cancer Society.
    [Hubrecht Institute]

    Press Release

    Replay and MD Anderson Announce FDA Clearance of IND Application for First-in-Class PRAME-Targeted T-cell Receptor Natural Killer (TCR-NK) Cell Therapy for Hematological Malignancies

    Replay and The University of Texas MD Anderson Cancer Center announced that the FDA has issued a ‘safe to proceed’ for the Investigational New Drug (IND) application for PRAME TCR/IL-15 NK (SY-307) for relapsed/refractory myeloid malignancies.
    [Replay]

    Press Release
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    JOB OPPORTUNITIES

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    University of Cambridge – Cambridge, England, United Kingdom

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    University of Pittsburgh – Pittsburgh, Pennsylvania, United States

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    University of Miami – Miami, Florida, United States

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    St. Jude Children’s Research Hospital – Memphis, Tennessee, United States

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