| Vol. 13.14 – 29 May, 2024 |
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| Investigators showed that FHD-286 induced differentiation and lethality in AML cells with MLL1 rearrangement or mutant NPM1, concomitantly causing perturbed chromatin accessibility and repression of c-Myc, PU.1, and CDK4/6. [Blood] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists identified circulating tumor cell-platelet adhesions by single-cell RNA sequencing and multiplex immunofluorescence of blood samples from multiple cancer types. [Hepatology] |
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| Using oral squamous cell carcinoma as a model, the authors demonstrated that PA28γ exhibited high expression in cancer-associated fibroblasts, and its expression significantly correlated with the severity of clinical indicators of malignancy. [Cancer Letters] |
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| Researchers showed that IRAK1 was upregulated in EOC tissues, and enhanced expression correlates with poorer overall survival. [Cell Death & Disease] |
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| Investigators showed that PRMT5 directly methylated STAT3 and enhanced its activated tyrosine phosphorylation in non-small cell lung cancer cells. [Communications Biology] |
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| The authors showed that vasorin (VASN) expression positively correlated with glioma-derived endothelial cell signatures in glioma patients. VASN promoted the endothelial differentiation capacity of glioma stem cell (GSC) in vitro and participates in the formation of GSC-derived vessels in vivo. [FASEB Journal] |
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| Researchers introduced oridonin, a small molecule with dual differentiation-inducing and cytotoxicity properties capable of eliminating tumor CSCs. [European Journal of Pharmacology] |
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| Investigators showed how YTH N6-methyladenosine RNA-binding protein F2 (YTHDF2) controlled the fate of cervical cancer cells and whether YTHDF2 could be a valid target for the therapy of cervical cancer. [Translational Oncology] |
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| E-cadherin levels were higher in CSC-E cells while vimentin and Slug more produced by CSC-M2 cells. CSC-M1 and CSC-M2 subpopulations showed higher proliferation, produced more colonies, and have stronger adhesion to the extracellular matrix. [Oral Diseases] |
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| The authors discuss critical mechanisms facilitating the plasticity between stem cell states and highlight the heterogeneity observed upon the appearance of fetal-like states. [Cell Reports] |
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| The FDA cleared Amgen’s drug, called Imdelltra, as a second or later-line treatment for adults with advanced small-cell lung cancer. [CNBC] |
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| Providence Therapeutic Holdings, Inc. and the Ontario Institute for Cancer Research announced the signing of a collaboration agreement for mRNA drug discovery and development. [Providence Therapeutics, Inc.] |
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| June 24 – 26, 2024 Madrid, Spain |
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| Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
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| Baylor College of Medicine – Houston, Texas, United States |
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| RMIT University – Melbourne, Victoria, Australia |
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| CRUK Scotland Institute – Glasgow, Scotland, United Kingdom |
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| Dana Farber Cancer Institute – Boston, Massachusetts, United States |
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