Cancer Stem Cell News Volume 13.16 | Jun 12 2024

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    2024-05-12 | CSCN 13.15


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 13.15 – 12 June, 2024
    TOP STORY

    A Developmental Constraint Model of Cancer Cell States and Tumor Heterogeneity

    Researchers posited a model by which cancer cell states are directly constrained by the organism’s “developmental map”, where a population of cancer cells traverses the developmental map, thereby generating a heterogeneous set of states whose interactions underpin emergent tumor behavior.
    [Cell]

    Abstract
    Guide to everything you need to know about cell separation.
    PUBLICATIONSRanked by the impact factor of the journal

    Stem-Cell States Converge in Multistage Cutaneous Squamous Cell Carcinoma Development

    Investigators generated gene networks for a wide range of stem cell markers from hundreds of samples taken from normal skin, benign tumors, and malignant tumors, and visualized expression of these network metagenes in single cells derived from multiple stages of carcinogenesis.
    [Science]

    AbstractGraphical Abstract

    Tumor Microenvironment-Induced FOXM1 Regulates Ovarian Cancer Stemness

    Researchers discovered that the pro-tumorigenic transcription factor FOXM1 was specifically induced by the microenvironment in ovarian CSCs, through activation of FAK/YAP signaling.
    [Cell Death & Disease]

    Full Article

    UCHL3 Induces Radiation Resistance and Acquisition of Mesenchymal Phenotypes by Deubiquitinating POLD4 in Glioma Stem Cells

    Expression and prognosis of the POLD family were analyzed in TCGA, the Chinese Glioma Genome Atlas and GEO datasets. Tumorsphere formation and in vitro limiting dilution assay were performed to investigate the effect of UCHL3-POLD4 on glioma stem cells self-renewal.
    [Cellular and Molecular Life Sciences]

    Full Article

    CD57 Defines a Novel Cancer Stem Cell That Drive Invasion of Diffuse Pediatric-Type High Grade Gliomas

    Ten highly invasive patient-derived orthotopic xenograft models of pediatric high-grade glioma were subjected to isolation of matching pairs of invasive and tumor core cells.
    [British Journal of Cancer]

    Abstract

    The Transcriptional Landscape of Cancer Stem-Like Cell Functionality in Breast Cancer

    The authors associated in vitro mammosphere formation assays with bulk tumor microarray profiling and deconvolution algorithms to map CSC functionality and the microenvironmental landscape in a large cohort of 125 breast tumors.
    [Journal of Translational Medicine]

    Full Article

    The HHEX-ABI2/SLC17A9 Axis Induces Cancer Stem Cell-Like Properties and Tumorigenesis in HCC

    Investigators reported that HHEX was a novel CSCs target for hepatocellular carcinoma (HCC). They found that HHEX was overexpressed in HCC tissues and high expression of HHEX was associated with poor survival.
    [Journal of Translational Medicine]

    Full Article

    GD2 and Its Biosynthetic Enzyme GD3 Synthase Promote Tumorigenesis in Prostate Cancer by Regulating Cancer Stem Cell Behavior

    Researchers showed that GD2 was expressed in a small subpopulation of prostate cancer cells in a subset of patients and a higher proportion of metastatic tumors.
    [Scientific Reports]

    Full Article

    2-Aryl-1H-imidazo[4,5-f][1,10]phenanthroline-Based Binuclear Ru(II)/Ir(III)/Re(I) Complexes As Mitochondria Targeting Cancer Stem Cell Therapeutic Agents

    The cytotoxic screening of the synthesized complexes revealed that complex Ru2L1 and Ir2L2 were two proficient complexes among all, but Ru2L1 was the most potent complex.
    [Medicinal Chemistry]

    AbstractGraphical Abstract
    REVIEWS

    Exploiting Ferroptosis Vulnerabilities in Cancer

    Scientists review recent advances in our understanding of the molecular mechanisms that underlie ferroptosis and highlight available tools for the modulation of ferroptosis sensitivity in cancer cells and communication with immune cells within the tumor microenvironment.
    [Nature Cell Biology]

    Abstract

    RhoJ: An Emerging Biomarker and Target in Cancer Research and Treatment

    There are various cancer treatment methods that target RhoJ signaling, such as direct binding to inhibit the RhoJ effector pocket, inhibiting RhoJ expression, blocking RhoJ upstream and downstream signals, and indirectly inhibiting RhoJ’s effect.
    [Cancer Gene Therapy]

    Full ArticleGraphical Abstract

    Cellular Origins and Lineage Plasticity in Cancer

    The identity of cancer “cells-of-origin” has historically been a source of controversy across tumor types, as it has not been possible to witness the dynamic events giving rise to human tumors.
    [Cold Spring Harbor Perspectives In Medicine]

    Full Article
    INDUSTRY AND POLICY NEWS

    Cancer Research Transformed by Landmark Gift to Queen’s University

    A transformational gift is set to significantly advance cancer research at Queen’s University. With support from Murray and Cara Sinclair, the university will build research capacity in an area of existing strength, establish advanced facilities, create training opportunities, and improve cancer care and treatments.
    [Queen’s University]

    Press Release

    FEATURED EVENT

    ISSCR Annual Meeting

    July 10-13, 2024
    Hamburg, Germany

    > See All Events

    JOB OPPORTUNITIES

    Research Coordinator – Colorectal Cancer Program

    University of North Carolina at Chapel Hill – Chapel Hill, North Carolina, United States

    Program Head – Breast Oncology

    Fred Hutchinson Cancer Center – Seattle, Washington, United States

    Postdoctoral Fellowships – Immuno-Oncology

    Centre for Oncology and Immunology – Hong Kong, Hong Kong

    Research Assistant – Oncology

    Washington University in St. Louis – St. Louis, Missouri, United States

    Postdoctoral Fellowship – Tumor Immunology and Immunotherapy

    Vanderbilt University – Nashville, Tennessee, United States

    > See All Jobs

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