| Vol. 13.15 – 26 June, 2024 |
| |
|
|
| Investigators reported that CSCN abundance is transcriptionally regulated by C-terminally phosphorylated p27. Mechanistically, this arises through p27 co-recruitment with STAT3/CBP to gene regulators of CSC self-renewal including MYC, the Notch ligand JAG1, and ANGPTL4. [Nature Communications] |
| |
|
|
PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Scientists demonstrated that DNA-damaging agents triggered Golgi dispersal in colorectal cancer, and CSCs possessed a greater degree of Golgi dispersal compared with differentiated cancer cells. [Cell Death & Disease] |
|
|
|
| Researchers examined colorectal cancer (CRC) samples and found that RANKL/RANK was elevated in CRC tissues compared with nearby normal tissues. Overexpression of RANK or addition of RANKL significantly increased the stemness and migration of CRC cells. [Cell Death & Disease] |
|
|
|
| The authors developed a 3D printed mold-based, dynamic, and personalized oral stem-like spheroids-on-a-chip, featuring unique serpentine loops and flat-bottom microwells arrangement. [Journal of Nanobiotechnology] |
|
|
|
| Researchers investigated the association between Pen2 expression and the stem-like properties of pancreatic ductal carcinoma cells. They analyzed Pen2 and its downstream target, Erb-B2 Receptor Tyrosine Kinase 4 (ErbB4), using public databases. [Biochimica Et Biophysica Acta-Molecular Basis of Disease] |
|
|
|
| Investigators elucidated the stemness-maintaining mechanism of human liver cancer stem-like cells (HLCSLCs) and provided a novel idea for the clearance of HLCSLCs. [Cancer Cell International] |
|
|
|
| Scientists investigated the mechanisms underlying chemoresistance in cervical cancer by focusing on the roles of glycogen metabolism and the pentose phosphate pathway. [Scientific Reports] |
|
|
|
| To evaluate the synergistic/antagonistic effects of doxorubucin and 5-fluorouracil, the combination index was calculated. Additionally, 3D tumor spheroids were used as another model. [Medical Oncology] |
|
|
|
|
The authors reported that circMALAT1 was significantly upregulated in esophageal squamous cell carcinoma (ESCC) CSC-like cells and primary tumors from ESCC patients. [MedComm] |
| | |
|
|
| CSC interaction with CD8+ T cells is even more complex as the CSC-derived exosomes contain Notch1 to stimulate stemness in non-tumor cells, and the inducible effect of Notch1 on PD-1 promotes CD8+ T cell exhaustion. [International Immunopharmacology] |
|
|
|
| Investigators discuss how oncolytic viruses as a therapeutic option target glioblastoma, especially the glioma stem cell subpopulation, and induce immunogenicity to remodel the tumor microenvironment, which subsequently enhances immunotherapies’ efficiency. [Biochimica Et Biophysica Acta-General Subjects] |
|
|
|
|
| PeerJ has partnered with Agorà , the Scientific Society of Aesthetic Medicine, to launch an Aesthetic and Regenerative Medicine Hub. [PeerJ (EurekAlert!)] |
|
|
|
|
| August 13-17, 2024 Long Island, New York, United States |
|
|
|
|
|
| National Cancer Institute – Bethesda, Maryland, United States |
|
|
|
| Amgen, Inc. – Houston, Texas, United States |
|
|
|
| BC Cancer – Vancouver, British Columbia, Canada |
|
|
|
| University of Adelaide – Adelaide, Australia |
|
|
|
| The University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
|
|
|
|