Cancer Stem Cell News Volume 13.15 | Jun 26 2024

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    2024-05-26 | CSCN 13.16


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 13.15 – 26 June, 2024
    TOP STORY

    C-Terminally Phosphorylated p27 Activates Self-Renewal Driver Genes to Program Cancer Stem Cell Expansion, Mammary Hyperplasia and Cancer

    Investigators reported that CSCN abundance is transcriptionally regulated by C-terminally phosphorylated p27. Mechanistically, this arises through p27 co-recruitment with STAT3/CBP to gene regulators of CSC self-renewal including MYC, the Notch ligand JAG1, and ANGPTL4.
    [Nature Communications]

    Full Article
    July 2024 Science Events
    PUBLICATIONSRanked by the impact factor of the journal

    Golgi Dispersal in Cancer Stem Cells Promotes Chemoresistance of Colorectal Cancer via the Golgi Stress Response

    Scientists demonstrated that DNA-damaging agents triggered Golgi dispersal in colorectal cancer, and CSCs possessed a greater degree of Golgi dispersal compared with differentiated cancer cells.
    [Cell Death & Disease]

    Full ArticleGraphical Abstract

    RANKL/RANK Signaling Recruits Tregs via the CCL20–CCR6 Pathway and Promotes Stemness and Metastasis in Colorectal Cancer

    Researchers examined colorectal cancer (CRC) samples and found that RANKL/RANK was elevated in CRC tissues compared with nearby normal tissues. Overexpression of RANK or addition of RANKL significantly increased the stemness and migration of CRC cells.
    [Cell Death & Disease]

    Full Article

    3D Stem-Like Spheroids-on-a-Chip for Personalized Combinatorial Drug Testing in Oral Cancer

    The authors developed a 3D printed mold-based, dynamic, and personalized oral stem-like spheroids-on-a-chip, featuring unique serpentine loops and flat-bottom microwells arrangement.
    [Journal of Nanobiotechnology]

    Full ArticleGraphical Abstract

    Pen2/ErbB4 Signaling Regulates Stemness of Pancreatic Ductal Carcinoma

    Researchers investigated the association between Pen2 expression and the stem-like properties of pancreatic ductal carcinoma cells. They analyzed Pen2 and its downstream target, Erb-B2 Receptor Tyrosine Kinase 4 (ErbB4), using public databases.
    [Biochimica Et Biophysica Acta-Molecular Basis of Disease]

    Abstract

    Targeted Silencing of SOCS1 by DNMT1 Promotes Stemness of Human Liver Cancer Stem-Like Cells

    Investigators elucidated the stemness-maintaining mechanism of human liver cancer stem-like cells (HLCSLCs) and provided a novel idea for the clearance of HLCSLCs.
    [Cancer Cell International]

    Full Article

    PCK1-Mediated Glycogenolysis Facilitates ROS Clearance and Chemotherapy Resistance in Cervical Cancer Stem Cells

    Scientists investigated the mechanisms underlying chemoresistance in cervical cancer by focusing on the roles of glycogen metabolism and the pentose phosphate pathway.
    [Scientific Reports]

    Full Article

    A Study with Cancer Stem Cells and Three-Dimensional Tumoroids: Investigation of the Combined Effects of 5-Fluorouracil and Doxorubicin in Breast Cancer

    To evaluate the synergistic/antagonistic effects of doxorubucin and 5-fluorouracil, the combination index was calculated. Additionally, 3D tumor spheroids were used as another model.
    [Medical Oncology]

    Full Article

    CircMALAT1 Promotes Cancer Stem-Like Properties and Chemoresistance via Regulating Musashi-2/C-myc Axis in Esophageal Squamous Cell Carcinoma

    The authors reported that circMALAT1 was significantly upregulated in esophageal squamous cell carcinoma (ESCC) CSC-like cells and primary tumors from ESCC patients.
    [MedComm]

    Full Article
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    REVIEWS

    Cancer Stem Cell-Derived Exosomes in CD8+ T Cell Exhaustion

    CSC interaction with CD8+ T cells is even more complex as the CSC-derived exosomes contain Notch1 to stimulate stemness in non-tumor cells, and the inducible effect of Notch1 on PD-1 promotes CD8+ T cell exhaustion.
    [International Immunopharmacology]

    Abstract

    Oncolytic Virotherapy Improves Immunotherapies Targeting Cancer Stemness in Glioblastoma

    Investigators discuss how oncolytic viruses as a therapeutic option target glioblastoma, especially the glioma stem cell subpopulation, and induce immunogenicity to remodel the tumor microenvironment, which subsequently enhances immunotherapies’ efficiency.
    [Biochimica Et Biophysica Acta-General Subjects]

    Abstract
    INDUSTRY AND POLICY NEWS

    PeerJ Launches Aesthetic and Regenerative Medicine Hub in Partnership with Agorà

    PeerJ has partnered with Agorà, the Scientific Society of Aesthetic Medicine, to launch an Aesthetic and Regenerative Medicine Hub.
    [PeerJ (EurekAlert!)]

    Press Release
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    National Cancer Institute – Bethesda, Maryland, United States

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    University of Adelaide – Adelaide, Australia

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    The University of Texas MD Anderson Cancer Center – Houston, Texas, United States

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