Cancer Stem Cell News Volume 13.17 | Jul 10 2024

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    2024-07-10 | CSCN 13.16


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 13.17 – 10 July, 2024
    TOP STORY

    PLD1 Is a Key Player in Cancer Stemness and Chemoresistance: Therapeutic Targeting of Cross-Talk Between the PI3K/Akt and Wnt/β-Catenin Pathways

    Crosstalk involving the phospholipase D and Wnt/β-catenin pathways promoted the progression of colorectal cancer and glioblastoma multiforme and reduced the sensitivity of cancer cells to standard therapies.
    [Experimental & Molecular Medicine]

    Full Article
    Your Online Resource for Cell Visualization. View StainsFile.
    PUBLICATIONSRanked by the impact factor of the journal

    Lysosomal Acid Lipase A Modulates Leukemia Stem Cell Response to Venetoclax/Tyrosine Kinase Inhibitor Combination Therapy in Blast Phase Chronic Myeloid Leukemia

    Investigators employed preclinical models of blast phase chronic myeloid leukemia to investigate the efficacy and underlying mechanism of leukemia stem cells-targeting with venetoclax/tyrosine kinase inhibitor combinations.
    [Haematologica]

    Abstract

    Promotion of Stem Cell-Like Phenotype of Lung Adenocarcinoma by FAM83A via Stabilization of ErbB2

    Through a global proteomics analysis, the study identified human epidermal growth factor receptor 2 as a crucial target of FAM83A. Mechanistically, FAM83A facilitated ErbB2 expression at the posttranslational modification level via the E3 ubiquitin ligase STUB1.
    [Cell Death & Disease]

    Full Article

    Astragalus Polysaccharides Sensitizes Ovarian Cancer Stem Cells to PARPi by Inhibiting Mitophagy via PINK1/Parkin Signaling

    The authors found that the synergistic effect of astragalus polysaccharides and PARP inhibitors was observed in ovarian cancer stem cells by decreasing cell viability and self-renewal potential while inducing apoptosis.
    [iScience]

    AbstractFull ArticleGraphical Abstract

    Cytosolic N-Terminal Formyl-Methionine Deformylation Derives Cancer Stem Cell Features and Tumor Progression

    Investigators demonstrated that removal of the Nt-formyl moiety of Nt-fMet-containing proteins resulted in a dramatic increase in the proliferation of SW480 colorectal cancer cells.
    [Scientific Reports]

    Full Article

    FERMT1 Suppression Induces Anti-Tumor Effects and Reduces Stemness in Glioma Cancer Cells

    The authors investigated the potential of FERMT1 as a prognostic biomarker and its role in regulating stemness through cell cycle in glioma.
    [Journal of Cancer Research and Clinical Oncology]

    Full Article

    Inhibiting Bruton’s Tyrosine Kinase to Counteract Chemoresistance and Stem Cell-Like Properties in Osteosarcoma

    Researchers delved into the expression levels of Bruton’s tyrosine kinase in osteosarcoma tissues by data from the GEO and TCGA database, revealing a marked increase in BTK expression compared with primary osteoblasts and a potential correlation with primary site progression.
    [Environmental Toxicology]

    Abstract

    Suppress the Cell Growth of Cancer Stem-Like Cells (NTERA-2) Using Sox2-Oct4 Decoy Oligodeoxynucleotide−Encapsulated Niosomes-Zinc Hybrid Nanocarriers under X-Irradiation

    The synergistic effects of Sox2-Oct4 decoy oligodeoxynucleotides-encapsulated Niosomes-zinc hybrid nanocarriers along with X‐irradiation conditions as a combinational therapy tool were investigated in the treatment of cancer-like stem cells.
    [Heliyon]

    Full ArticleGraphical Abstract

    CENPA Facilitates Glioma Stem Cell Stemness and Suppress Ferroptosis to Accelerate Glioblastoma Multiforme Progression by Promoting GBP2 Transcription

    GSCs proliferation and stemness were assessed using EdU assay and sphere formation assay. Cell ferroptosis was evaluated by detecting related factors.
    [Pathology – Research and Practice]

    AbstractGraphical Abstract
    Explore this validated protocol for high-efficiency gene editing of Human Pluripotent Stem Cells using the ArciTect™ CRISPR-Cas9 System.
    REVIEWS

    Pharmacological Targeting of the Cancer Epigenome

    Scientists discuss recent developments for each epigenetic drug class and their implications for therapy, as well as highlight new insights into the role of epigenetics in cancer.
    [Nature Cancer]

    Abstract

    Post-Translational Modifications: The Potential Ways for Killing Cancer Stem Cells

    Investigators accentuate the critical significance of several prevalent post-translational protein modifications (PTMs) and the intricate interplay of PTM crosstalk in regulating CSC behavior.
    [Heliyon]

    Full Article
    INDUSTRY AND POLICY NEWS

    Why Cancer Risk Declines Sharply in Old Age

    Becoming an octogenarian could have an unexpected benefit: a decrease in the risk of lung cancer, according to two studies in mice. The results, posted as preprints on the bioRxiv server, highlight specific genes that could contribute to the declining risk and reveal a surprising link between them and iron metabolism.
    [Nature News]

    Editorial

    Two Faculty of Health Sciences Cancer Researchers Awarded Canada Research Chairs

    Two members of McMaster’s Faculty of Health Sciences and the Centre for Discovery in Cancer Research have been named Canada Research Chairs. Dr. Hong Han is focused on high-throughput investigation of cancer biology, specifically alternative splicing and coordinated multilayer gene regulations.
    [McMaster University]

    Press Release
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    July 28 – August 1, 2024
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    JOB OPPORTUNITIES

    Associate Professor of Medicine – Oncology

    Indiana University School of Medicine – Indianapolis, Indiana, United States

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    University of Cincinnati – Cincinnati, Ohio, United States

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    Amgen, Inc. – Houston, Texas, United States

    Researchers – Digital Models of Precision Oncology

    University of Adelaide – Adelaide, Australia

    Senior Research Technician – Breast Cancer Biology

    University of Chicago – Chicago, Illinois, United States

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