Cancer Stem Cell News Volume 13.18 | Jul 24 2024

    0
    34








    2024-07-24 | CSCN 13.18


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 13.18 – 24 July, 2024
    TOP STORY

    PHF6 Suppresses Self-Renewal of Leukemic Stem Cells in AML

    Scientists reported that Phf6 knockout increased the aggressiveness of Hoxa9-driven acute myeloid leukemia over serial transplantation, and increased the frequency of leukemia initiating cells.
    [Leukemia]

    Full Article
    These free journal club templates and resources will help you effectively run a scientific journal club.
    PUBLICATIONSRanked by the impact factor of the journal

    TSP50 Facilitates Breast Cancer Stem Cell-Like Properties Maintenance and Epithelial-Mesenchymal Transition via PI3K p110α Mediated Activation of AKT Signaling Pathway

    TSP50 was negatively correlated with the prognosis of patients with breast cancer. TSP50 promoted CSC-like traits and EMT in both breast cancer cells and mouse xenograft tumor tissues.
    [Journal of Experimental & Clinical Cancer Research]

    Full Article

    PIM1 Is a Potential Therapeutic Target for the Leukemogenic Effects Mediated by JAK/STAT Pathway Mutations in T-ALL/LBL

    The authors combined the analysis of molecular data from T-ALL/LBL patients with the generation of hematopoietic cellular models to reveal that JAK/STAT pathway mutations are associated with an aberrant transcriptional profile.
    [NPJ Precision Oncology]

    Full Article

    Discovering Cancer Stem-Like Molecule, Nuclear Factor I X, Using Spatial Transcriptome in Gastric Cancer

    Researchers identified Nuclear Factor IX as a critical regulator of cancer stemness in gastric cancer and evaluated its clinicopathological significance and function.
    [Cancer Science]

    Full Article

    FXN Targeting Induces Cell Death in Ovarian Cancer Stem-Like Cells through PRDX3-Mediated Oxidative Stress

    The authors enriched ovarian cancer stem-like cells (OCSCs) through mammosphere culture, as an OCSC model. OCSLCs displayed heightened ferroptosis susceptibility, correlating with elevated FXN levels compared to non-stem ovarian cancer cells.
    [iScience]

    Full ArticleGraphical Abstract

    Targeting Ovarian Cancer Stem Cells by Dual Inhibition of the Long Noncoding RNA HOTAIR and Lysine Methyltransferase EZH2

    Investigators generated HOXC transcript antisense RNA (HOTAIR) knock-out high-grade serous ovarian cancer cell lines using paired CRISPR guide RNA design to investigate the function of HOTAIR.
    [Molecular Cancer Therapeutics]

    Abstract

    Changes of Circulating Tumor Cells Expressing CD90 and EpCAM in Early-Phase of Atezolizumab and Bevacizumab for Hepatocellular Carcinoma

    Researchers investigated the cellular characteristics of circulating tumor cells focusing on monitoring during atezolizumab and bevacizumab therapy in patients with HCC. Peripheral blood samples were collected from 10 healthy controls and 40 patients with HCC.
    [Heliyon]

    Full Article

    Polyploid Giant Cancer Cells Induced by Docetaxel Exhibit a Senescence Phenotype With the Expression of Stem Cell Markers in Ovarian Cancer Cells

    Ovarian cancer cells were treated with Docetaxel (Doc), and then the effect of Doc on cellular viability was evaluated by MTT assay and microscopic imaging analysis.
    [PLOS One]

    Full Article
    Sign up to read articles, listen to our podcast, or download free toolkits to help you thrive as a scientist.
    REVIEWS

    HER2-Targeted Therapies Beyond Breast Cancer — an Update

    Scientists provide an update on the current development landscape of HER2-targeted therapies beyond breast cancer, as well as anticipated future HER2-directed treatment strategies to overcome resistance and thereby improve efficacy and patient outcomes.
    [Nature Reviews Clinical Oncology]

    Abstract

    Targeting Cancer Stem Cells in Multiple Myeloma

    Investigators review advances in understanding multiple myeloma (MM) stem cells (MMSCs) and their role in drug resistance to MM therapies. They also discuss novel therapeutic strategies to overcome MM stem cell-mediated relapses and drug resistance.
    [Trends In Cancer]

    Full Article
    INDUSTRY AND POLICY NEWS

    So You Got a Null Result. Will Anyone Publish It?

    Researchers have tried a bunch of strategies to get more negative results into the literature. Nature asks whether they are working.
    [Nature News]

    Press Release

    U of A Oncology Researcher Named to the Order of Canada

    Vickie Baracos, University of Alberta oncology professor, researcher and Alberta Cancer Foundation Chair in Palliative Medicine from 2003-23, was recently awarded the Order of Canada. She was honoured for her groundbreaking insights into the fundamental biology of cachexia.
    [University of Alberta]

    Press Release
    FEATURED EVENT

    The 11th Aging Research & Drug Discovery Meeting

    August 26 – 30, 2024
    Copenhagen, Denmark

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Immunology of Lung Cancer

    Dalhousie University – Halifax, Nova Scotia, Canada

    Research Associate – GI Cancer Research

    City of Hope – Monrovia, California, United States

    Associate Professor of Medicine – Oncology

    Indiana University School of Medicine – Indianapolis, Indiana, United States

    Research Fellow – Cancer Biology

    University of Cincinnati – Cincinnati, Ohio, United States

    Senior Oncology Specialist – Lung Cancer

    Amgen, Inc. – Houston, Texas, United States

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2