 | | Vol. 13.19 – 7 August, 2024 |
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| Researchers examined how IL-33 derived from CSCs facilitated the development of an immunosuppressive microenvironment. CSCs with high NRF2 activity redistributed nuclear IL-33 to the cytoplasm and released IL-33 as cargo of large oncosomes.
[Immunity] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors investigated the role of quiescence and related molecular mechanisms in acute myeloid leukemia pathogenesis and leukemic stem cell functions to identify potential therapeutic targets.
[Science Translational Medicine] |
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| Investigators leveraged machine-learning tools by evaluating expression of genes of pharmacological relevance to standard-AML chemotherapy in a discovery-cohort of pediatric AML patients and defined a 5-gene-drug resistance score that was predictive of outcome.
[NPJ Precision Oncology] |
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| Scientists tested the efficacy of the CD34-specific bispecific T cell engager (BTE) using in vitro expanded γδ T cells as effectors. They showed that the BTEs bind to γδ T-cells and CD34+ leukemic cell lines and induce target cell killing in a dose-dependent manner.
[Oncoimmunology] |
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| KrasLSL−G12D/WT lung cancer model and LLC1 syngeneic tumor model were used to study the effect of Olanzapine on cancer stemness and anxiety-like behaviors.
[Cell Communication and Signaling] |
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| Nrf2 and assembly factor for spindle microtubules (ASPM) expression facilitated epithelial–mesenchymal transition, CSCs feature, and sasculogenic mimicry formation of HCC cells under hypoxia.
[Journal of Gastroenterology] |
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| The authors showed the expression profile of hcast 3-25 (a Type III calpastatin variant devoid of inhibitory units) and the members of the system in several patient-derived glioblastoma stem cells, exploring the relationship between hcast 3-25 and activation/activity of calpains.
[Frontiers In Molecular Biosciences] |
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| Investigators showed that USP22 was essential in maintaining breast cancer cell stemness by promoting the transcription of integrin β1 (ITGB1). Both genetic and pharmacological inhibition of USP22 largely impaired breast CSCs self-renewal and prevented their metastasis.
[iScience] |
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| Scientists leveraged the SW480 cell line as a model system to investigate the molecular and functional diversity of colon cancer cells.
[iScience] |
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| Researchers identified WDR72 as a CSCs-related gene in gastric cancer epithelial cells. WDR72 was highly expressed in gastric cancer tissues, and high expression of WDR72 was associated with inferior prognosis of patients.
[Heliyon] |
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| Genes differentially expressed in esophageal carcinoma were analyzed in the GEO database, followed by analyses of GO and KEGG enrichment to screen the hub gene.
[Clinical and Translational Oncology] |
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| Investigators highlight examples of functional circRNAs in specific cancers, which satisfy critical criteria, including their physical co-association with the target and circRNA abundance at stoichiometrically valid quantities.
[Nature Reviews Cancer] |
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| The authors discuss the role of ceRNAs in CSCs’ function. Targeting ceRNAs may open the path for new cancer therapeutic targets and can be used in clinical research.
[Heliyon] |
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| The International Space Station (ISS) National Laboratory, in partnership with NASA’s Biological and Physical Sciences division, jointly announced the selection of five projects through the inaugural Igniting Innovation solicitation for cancer and other disease-related research and on the ISS.
[ISS National Laboratory] |
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| Research Manitoba is supporting Anonna’s work through a Master’s Studentship Award, valued at $20,000, for the upcoming academic year. Anonna is an international student in the Master of Science program at Brandon University, working in Dr. Majumder’s Breast Cancer Cell & Molecular Research Laboratory.
[Brandon University] |
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| Stand Up To Cancer in the US and our Stand Up To Cancer campaign are giving two international teams each a further £3.75m in funding to drive progress for children and young people with cancer.
[Cancer Research UK] |
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| September 15-18, 2024
Boston, Massachusetts, United States |
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| | St. Anna Children’s Cancer Research Institute – Vienna, Austria |
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| | IDIBAPS Research Institute – Barcelona, Spain |
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| | Ohio State University – Columbus, Ohio, United States |
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Postdoctoral Position – Tumor Immunology, Lung Cancer | | National Institutes of Health – Bethesda, Maryland, United States |
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Research Associate – GI Cancer Research | | City of Hope – Monrovia, California, United States |
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