Cancer Stem Cell News Volume 13.22 | Sep 18 2024

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    2024-09-18 | CSCN 13.22


    Cancer Stem Cell News by STEMCELL Technologies
    Vol. 13.21 – 18 September, 2024
    TOP STORY

    Targeted Therapy Guided by Circulating Tumor DNA Analysis in Advanced Gastrointestinal Tumors

    An updated analysis of 4037 patients inThe GOZILA study, a nationwide, prospective observational circulating tumor (ct)DNA profiling study, delineated the clinical utility of ctDNA profiling in advanced solid tumors.
    [Nature Medicine]

    Full Article
    New protocol to isolate urine-derived EVs using EasySepâ„¢ EV Human Positive Selection Kits.
    PUBLICATIONSListed by the impact factor of the journal

    NAC1 Promotes Stemness and Regulates Myeloid-Derived Cell Status in Triple-Negative Breast Cancer

    Scientists revealed that nucleus accumbens associated protein 1 (NAC1), a member of the BTB/POZ gene family, plays a crucial role in triple negative breast cancer by maintaining tumor stemness and influencing myeloid-derived suppressor cells.
    [Molecular Cancer]

    Full Article

    Circulating Tumor DNA-Based Stratification Strategy for Chemotherapy Plus PD-1 Inhibitor in Advanced Non-Small-Cell Lung Cancer

    Investigators performed high-throughput panel-based deep next-generation sequencing and low-pass whole genome sequencing on prospectively collected circulating tumor DNA specimens from 460 patients in the Phase III CHOICE-01 study at different time points.
    [Cancer Cell]

    Full ArticleGraphical Abstract

    ALDH1A3 Is the Switch That Determines the Balance of ALDH+ and CD24−CD44+ Cancer Stem Cells, EMT-MET, and Glucose Metabolism in Breast Cancer

    The authors found that aldehyde dehydrogenase 1A3 (ALDH1A3) regulates these cancer-promoting processes and the abundance of the two distinct breast CSC populations defined by high ALDH activity and CD24−CD44+ cell surface expression.
    [Oncogene]

    Full ArticleGraphical Abstract

    Mcam Stabilizes a Luminal Progenitor-Like Breast Cancer Cell State via Ck2 Control and Src/Akt/Stat3 Attenuation

    Scientists demonstrated that the cell surface glycoprotein Mcam maintained the tumorigenic luminal progenitor-like epithelial cell state, leading to Basal-like mammary cancers.
    [NPJ Breast Cancer]

    Full Article

    4-Hydroxynonenal Promotes Colorectal Cancer Progression through Regulating Cancer Stem Cell Fate

    Human CRC cells were exposed to 4-HNE, and CSC signaling was analyzed using quantitative real-time PCR, immunofluorescent staining, fluorescence-activated cell sorting, and bioinformatic analysis.
    [Antioxidants & Redox Signaling]

    Abstract

    Development of a Prognostic Model for NSCLC Based on Differential Genes in Tumor Stem Cells

    Researchers performed univariate regression analyses on the differential genes to identify potential prognostic genes. They created a machine learning framework based on potential prognostic genes, which combines 10 machine learning methods and their 101 combinations to get the optimal prognostic risk model.
    [Scientific Reports]

    Full Article

    Human Intermediate Prostate Cancer Stem Cells Contribute to the Initiation and Development of Prostate Adenocarcinoma

    Investigators developed a customized medium to culture primary human intermediate prostate cells, which were transplanted into male immunodeficient NCG mice to examine tumorigenicity in vivo.
    [Stem Cell Research]

    Full Article

    Autofluorescent Cancer Stem Cells: Potential Biomarker to Predict Recurrence in Resected Colorectal Tumor

    75 freshly-resected tumors were analyzed, by flow cytometry. Autofluorescence was categorized as high or low and results were correlated with histological features and clinical variables.
    [Cancer Research Communications]

    Abstract
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    REVIEWS

    The Evolutionary Theory of Cancer: Challenges and Potential Solutions

    The authors identify limits in the theoretical performance of the clonal evolution model and provide solutions to overcome those limits.
    [Nature Reviews Cancer]

    Abstract

    Epigenetic Control of Immunoevasion in Cancer Stem Cells

    Investigators summarize epigenetic modifications of DNA and histones through which CSCs evade immune recognition or elimination, and propose that such alterations constitute promising therapeutic targets to increase the sensitivity of some malignancies to immunotherapy.
    [Trends In Cancer]

    Abstract
    INDUSTRY AND POLICY NEWS

    Cancer Research Transformed by Landmark Gift to Queen’s University

    A gift is set to significantly advance cancer research at Queen’s University. With support from Murray and Cara Sinclair, the university will build research capacity in an area of existing strength, establish advanced facilities and work to improve cancer care and treatments.
    [Queen’s University]

    Press Release

    Westmead Hospital Dermatologist Wins Highly Coveted Award for Revolutionary Melanoma Research

    Head of Dermatology at Westmead Hospital, Dr. Pablo Fernández-Peñas, and his team of researchers at the Australian Cancer Research Foundation & Australian Centre of Excellence in Melanoma Imaging and Diagnosis, have won the Eureka Prize for Interdisciplinary Scientific Research.
    [The Pulse]

    Press Release
    FEATURED EVENT

    ASHI 50th Annual Meeting

    October 21-25, 2024
    Anaheim, California, United States

    > See All Events

    JOB OPPORTUNITIES

    Senior Technical Writer – Melanoma Research Program

    University of Texas MD Anderson Cancer Center – Houston, Texas, United States

    Group Leader – Stem Cell Science

    Cambridge Stem Cell Institute – Cambridge, England, United Kingdom

    Postdoctoral Fellowship – Cancer Biology and Gene Therapy

    UT Southwestern – Dallas, Texas, United States

    Research Technician – Stem Cell Biology

    Fred Hutch Cancer Center – Seattle, Washington, United States

    Postdoctoral Fellow – Liver Cancer Development

    Tulane University – New Orleans, Louisiana, United States

    > See All Jobs

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